C8A731 (C8A731_STAAU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase EMBL EEV10533.1

Gene names

ORF Names:

SACG_00490 EMBL EEV10533.1

Organism

Staphylococcus aureus subsp. aureus 68-397 EMBL EEV10533.1

Taxonomic identifier

585146 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. SAAS SAAS023019 1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. SAAS SAAS023019
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. SAAS SAAS023019 Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. SAAS SAAS023019

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis SAAS SAAS023019
Cellular component	Cytoplasm SAAS SAAS023019
Ligand	ATP-binding SAAS SAAS023019 Nucleotide-binding
Molecular function	Hydrolase SAAS SAAS023019 EMBL EEV10533.1
Technical term	Multifunctional enzyme SAAS SAAS023019
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: InterPro phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C8A731 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: EB5AA9395B1DB6D7	FASTA	210	23,973
	10 20 30 40 50 60 MTNYKIDFSK GLVPAILQDN QTKQVLMLGY MNQEAFDKTI EDGVVCFYSR SKQRLWTKGE 70 80 90 100 110 120 TSGHTQRVKD IHVDCDNDTI LIDVIPNGPT CHTGSQSCFN TEVPFSVQTL AQTVQDSAQS 130 140 150 160 170 180 NNEKSYTKYL LTEGIEKITK KYGEEAFEVV IEAIKGDKKA FVSEVADELY HLFVLMHALG 190 200 210 VDFSEIEAEL ARRHHKRNNF KGERQNIEQW

References

[1]

"The Genome Sequence of Staphylococcus aureus strain 68-397." The Broad Institute Genome Sequencing Platform Feldgarden M., Robinson A., Wong A., Smyth D., Young S.K., Zeng Q., Koehrsen M., Godfrey P., Alvarado L., Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S. , Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Wirth D.F., Galagan J., Nusbaum C., Birren B. Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 68-397 EMBL EEV10533.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG700574 Genomic DNA. Translation: EEV10533.1.
3D structure databases
ProteinModelPortal	C8A731.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	26218992. VBIStaAur3727_0589.
Family and domain databases
HAMAP	MF_01019. HisIE. [Tree] MF_01020. HisE. [Tree]
InterPro	IPR023019. His_synth_HisIE. IPR008179. PRib-ATP_PPHydrolase. IPR021130. PRib-ATP_PPHydrolase-like. IPR002496. PRib_AMP_CycHydrolase. [Graphical view]
Pfam	PF01502. PRA-CH. 1 hit. PF01503. PRA-PH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03188. Histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C8A731_STAAU

Accession

Primary (citable) accession number: C8A731

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	December 14, 2011
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)