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Protein

Kynureninase

Gene

BNA5

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (BNA5), Kynureninase (BNA5)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (BNA4)
  2. Kynureninase (BNA5), Kynureninase (BNA5)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (BNA1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei165Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei166Pyridoxal phosphateUniRule annotation1
Binding sitei277Pyridoxal phosphateUniRule annotation1
Binding sitei280Pyridoxal phosphateUniRule annotation1
Binding sitei302Pyridoxal phosphateUniRule annotation1
Binding sitei342Pyridoxal phosphateUniRule annotation1
Binding sitei370Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5UniRule annotation
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:BNA5UniRule annotation
ORF Names:NECHADRAFT_49794Imported
OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)Imported
Taxonomic identifieri660122 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
Proteomesi
  • UP000005206 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei303N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi140110.NechaP49794

Structurei

3D structure databases

ProteinModelPortaliC7ZJ53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 321Aminotran_5InterPro annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni193 – 196Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

InParanoidiC7ZJ53
KOiK01556
OrthoDBiEOG092C20ON

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 3 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 2 hits
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

C7ZJ53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSGFVDRL RSGASPKFPQ DANSLEFARH LDSQDKLSHL RDEFVIPTKR
60 70 80 90 100
SLKKKALDGS IPSHGASSNG TNGTNGHSNG HNGSSDDSEQ CLYFVGNSLG
110 120 130 140 150
AQPKAVREYL NAQLETWASI GVNGHFSAMG NSPLTPWQDM AEDCAIKSAD
160 170 180 190 200
IVGASPSEIV IMNTLTANLH FLMASFYKPN EKRHKIILEW KPFPSDHYAI
210 220 230 240 250
ESQVVWHGLD PEKSMVKIHP NDDFIITTDL ILSTIDEHAE DTALLLLPGI
260 270 280 290 300
QYYSGQLFDI PRITAYAQER GIVVGWDLAH AAGNVELKLH DWNVDFACWC
310 320 330 340 350
TYKYINAGPG SIAGAYVHEK HGKVEFKDDS GKPTYRPRLM GWYGGDKSVR
360 370 380 390 400
FNMDNKFVPT VGAGGFQLSN PSAIDLASLS GALSVFNKTK MYEIRSKALV
410 420 430 440 450
LTAYAEHLLD QIISESSDET PLFRIITPRD PAQRGTQLSV LLREGLMERV
460 470 480 490
SEALEENGVI CDKRKPDVIR VAPVPLYTRF EDVWKFMQVL RGALSQ
Length:496
Mass (Da):55,011
Last modified:October 13, 2009 - v1
Checksum:i8FA291034D95655B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG698932 Genomic DNA Translation: EEU35954.1
RefSeqiXP_003041667.1, XM_003041621.1

Genome annotation databases

EnsemblFungiiNechaT49794; NechaP49794; NechaG49794
GeneIDi9674071
KEGGinhe:NECHADRAFT_49794

Similar proteinsi

Entry informationi

Entry nameiC7ZJ53_NECH7
AccessioniPrimary (citable) accession number: C7ZJ53
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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