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C7ZJ53

- C7ZJ53_NECH7

UniProt

C7ZJ53 - C7ZJ53_NECH7

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Protein

Kynureninase

Gene

BNA5

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei165 – 1651Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei166 – 1661Pyridoxal phosphateUniRule annotation
Binding sitei277 – 2771Pyridoxal phosphateUniRule annotation
Binding sitei280 – 2801Pyridoxal phosphateUniRule annotation
Binding sitei302 – 3021Pyridoxal phosphateUniRule annotation
Binding sitei342 – 3421Pyridoxal phosphateUniRule annotation
Binding sitei370 – 3701Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5UniRule annotation
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:BNA5UniRule annotation
ORF Names:NECHADRAFT_49794Imported
OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)Imported
Taxonomic identifieri660122 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
ProteomesiUP000005206: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei303 – 3031N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC7ZJ53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni193 – 1964Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

InParanoidiC7ZJ53.
KOiK01556.
OrthoDBiEOG7V1G0J.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 2 hits.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

C7ZJ53-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELSGFVDRL RSGASPKFPQ DANSLEFARH LDSQDKLSHL RDEFVIPTKR
60 70 80 90 100
SLKKKALDGS IPSHGASSNG TNGTNGHSNG HNGSSDDSEQ CLYFVGNSLG
110 120 130 140 150
AQPKAVREYL NAQLETWASI GVNGHFSAMG NSPLTPWQDM AEDCAIKSAD
160 170 180 190 200
IVGASPSEIV IMNTLTANLH FLMASFYKPN EKRHKIILEW KPFPSDHYAI
210 220 230 240 250
ESQVVWHGLD PEKSMVKIHP NDDFIITTDL ILSTIDEHAE DTALLLLPGI
260 270 280 290 300
QYYSGQLFDI PRITAYAQER GIVVGWDLAH AAGNVELKLH DWNVDFACWC
310 320 330 340 350
TYKYINAGPG SIAGAYVHEK HGKVEFKDDS GKPTYRPRLM GWYGGDKSVR
360 370 380 390 400
FNMDNKFVPT VGAGGFQLSN PSAIDLASLS GALSVFNKTK MYEIRSKALV
410 420 430 440 450
LTAYAEHLLD QIISESSDET PLFRIITPRD PAQRGTQLSV LLREGLMERV
460 470 480 490
SEALEENGVI CDKRKPDVIR VAPVPLYTRF EDVWKFMQVL RGALSQ
Length:496
Mass (Da):55,011
Last modified:October 13, 2009 - v1
Checksum:i8FA291034D95655B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG698932 Genomic DNA. Translation: EEU35954.1.
RefSeqiXP_003041667.1. XM_003041621.1.

Genome annotation databases

EnsemblFungiiNechaT49794; NechaP49794; NechaG49794.
GeneIDi9674071.
KEGGinhe:NECHADRAFT_49794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG698932 Genomic DNA. Translation: EEU35954.1 .
RefSeqi XP_003041667.1. XM_003041621.1.

3D structure databases

ProteinModelPortali C7ZJ53.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii NechaT49794 ; NechaP49794 ; NechaG49794 .
GeneIDi 9674071.
KEGGi nhe:NECHADRAFT_49794.

Phylogenomic databases

InParanoidi C7ZJ53.
KOi K01556.
OrthoDBi EOG7V1G0J.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 2 hits.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVIImported.

Entry informationi

Entry nameiC7ZJ53_NECH7
AccessioniPrimary (citable) accession number: C7ZJ53
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 26, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3