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C7Z9Q2

- C7Z9Q2_NECH7

UniProt

C7Z9Q2 - C7Z9Q2_NECH7

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

NECHADRAFT_70385

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei361 – 3611S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
ORF Names:NECHADRAFT_70385Imported
OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)Imported
Taxonomic identifieri660122 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
ProteomesiUP000005206: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni311 – 3144S-adenosyl-L-methionine bindingUniRule annotation
Regioni335 – 34410S-adenosyl-L-methionine bindingUniRule annotation
Regioni397 – 3982S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

Phylogenomic databases

InParanoidiC7Z9Q2.
KOiK11427.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7Z9Q2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLFGGKNNK FKADPPKIRI EKVVVDRPAT KPKPKPKPAL SGSASRSSSS
60 70 80 90 100
HRPSPKPLAR QASHSPYPSS SDEKRLERKR KASSVSRRSP ASDRIEFDKD
110 120 130 140 150
SDGEDDGWMT LDSNKRQRKG TEDGFVDTNR KLRSVRAFKD RLDRRSFIHA
160 170 180 190 200
VDVASLQHKC VPVMGAQKED VAIELQYPSL QPREKYELVW GKDKIDAVEA
210 220 230 240 250
SIKVVRHVAE TYLTDDEAEP FTNPNGGIIR RLEKASNRNI QDLMGFKTAL
260 270 280 290 300
REYNEKLLAL VEDGVISKNL DNMHELPQHL VAFILDQIYD RTVAPKVELL
310 320 330 340 350
SKYENGTDYV YGELLHPFIS KILVEQTQMT SGQVFVDLGS GVGNVVLQAA
360 370 380 390 400
LEIGCESWGC EMMENACNLG EAQKKEFDAR CTLWGIKPGK AHLERGDFRH
410 420 430 440 450
NQHILEALRR ADVILVNNKA FTSSLNDDLT RMFLDLKPGA KIVSLKSFVA
460 470 480 490
EKNNNHNIND VGSRILDVEE CTYPEGYVSW TNAGGSYFIS TRKQ
Length:494
Mass (Da):55,613
Last modified:October 13, 2009 - v1
Checksum:iFFAAEBC488817BED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG698912 Genomic DNA. Translation: EEU39139.1.
RefSeqiXP_003044852.1. XM_003044806.1.

Genome annotation databases

EnsemblFungiiNechaT70385; NechaP70385; NechaG70385.
GeneIDi9672034.
KEGGinhe:NECHADRAFT_70385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG698912 Genomic DNA. Translation: EEU39139.1 .
RefSeqi XP_003044852.1. XM_003044806.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii NechaT70385 ; NechaP70385 ; NechaG70385 .
GeneIDi 9672034.
KEGGi nhe:NECHADRAFT_70385.

Phylogenomic databases

InParanoidi C7Z9Q2.
KOi K11427.
OrthoDBi EOG7KH9VN.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVIImported.

Entry informationi

Entry nameiC7Z9Q2_NECH7
AccessioniPrimary (citable) accession number: C7Z9Q2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3