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C7Z9Q2

- C7Z9Q2_NECH7

UniProt

C7Z9Q2 - C7Z9Q2_NECH7

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Protein
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Gene
NECHADRAFT_70385
Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei361 – 3611S-adenosyl-L-methionine By similarityUniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferase
Gene namesi
ORF Names:NECHADRAFT_70385Imported
OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Taxonomic identifieri660122 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
ProteomesiUP000005206: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni311 – 3144S-adenosyl-L-methionine binding By similarityUniRule annotation
Regioni335 – 34410S-adenosyl-L-methionine binding By similarityUniRule annotation
Regioni397 – 3982S-adenosyl-L-methionine binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK11427.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7Z9Q2-1 [UniParc]FASTAAdd to Basket

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MRLFGGKNNK FKADPPKIRI EKVVVDRPAT KPKPKPKPAL SGSASRSSSS    50
HRPSPKPLAR QASHSPYPSS SDEKRLERKR KASSVSRRSP ASDRIEFDKD 100
SDGEDDGWMT LDSNKRQRKG TEDGFVDTNR KLRSVRAFKD RLDRRSFIHA 150
VDVASLQHKC VPVMGAQKED VAIELQYPSL QPREKYELVW GKDKIDAVEA 200
SIKVVRHVAE TYLTDDEAEP FTNPNGGIIR RLEKASNRNI QDLMGFKTAL 250
REYNEKLLAL VEDGVISKNL DNMHELPQHL VAFILDQIYD RTVAPKVELL 300
SKYENGTDYV YGELLHPFIS KILVEQTQMT SGQVFVDLGS GVGNVVLQAA 350
LEIGCESWGC EMMENACNLG EAQKKEFDAR CTLWGIKPGK AHLERGDFRH 400
NQHILEALRR ADVILVNNKA FTSSLNDDLT RMFLDLKPGA KIVSLKSFVA 450
EKNNNHNIND VGSRILDVEE CTYPEGYVSW TNAGGSYFIS TRKQ 494
Length:494
Mass (Da):55,613
Last modified:October 13, 2009 - v1
Checksum:iFFAAEBC488817BED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG698912 Genomic DNA. Translation: EEU39139.1.
RefSeqiXP_003044852.1. XM_003044806.1.

Genome annotation databases

EnsemblFungiiNechaT70385; NechaP70385; NechaG70385.
GeneIDi9672034.
KEGGinhe:NECHADRAFT_70385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG698912 Genomic DNA. Translation: EEU39139.1 .
RefSeqi XP_003044852.1. XM_003044806.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii NechaT70385 ; NechaP70385 ; NechaG70385 .
GeneIDi 9672034.
KEGGi nhe:NECHADRAFT_70385.

Phylogenomic databases

KOi K11427.
OrthoDBi EOG7KH9VN.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI.

Entry informationi

Entry nameiC7Z9Q2_NECH7
AccessioniPrimary (citable) accession number: C7Z9Q2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi