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C7Z9Q2 (C7Z9Q2_NECH7) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific PIRNR PIRNR017570

EC=2.1.1.43 PIRNR PIRNR017570
Alternative name(s):
Histone H3-K79 methyltransferase PIRNR PIRNR017570
Gene names
ORF Names:NECHADRAFT_70385 EMBL EEU39139.1
OrganismNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi) [Reference proteome]
Taxonomic identifier660122 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity. PIRNR PIRNR017570

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR017570

Subcellular location

Nucleus By similarity PIRNR PIRNR017570.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. PIRNR PIRNR017570

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region311 – 3144S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region335 – 34410S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region397 – 3982S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1

Sites

Binding site3611S-adenosyl-L-methionine By similarity PIRSR PIRSR017570-1

Sequences

Sequence LengthMass (Da)Tools
C7Z9Q2 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: FFAAEBC488817BED

FASTA49455,613
        10         20         30         40         50         60 
MRLFGGKNNK FKADPPKIRI EKVVVDRPAT KPKPKPKPAL SGSASRSSSS HRPSPKPLAR 

        70         80         90        100        110        120 
QASHSPYPSS SDEKRLERKR KASSVSRRSP ASDRIEFDKD SDGEDDGWMT LDSNKRQRKG 

       130        140        150        160        170        180 
TEDGFVDTNR KLRSVRAFKD RLDRRSFIHA VDVASLQHKC VPVMGAQKED VAIELQYPSL 

       190        200        210        220        230        240 
QPREKYELVW GKDKIDAVEA SIKVVRHVAE TYLTDDEAEP FTNPNGGIIR RLEKASNRNI 

       250        260        270        280        290        300 
QDLMGFKTAL REYNEKLLAL VEDGVISKNL DNMHELPQHL VAFILDQIYD RTVAPKVELL 

       310        320        330        340        350        360 
SKYENGTDYV YGELLHPFIS KILVEQTQMT SGQVFVDLGS GVGNVVLQAA LEIGCESWGC 

       370        380        390        400        410        420 
EMMENACNLG EAQKKEFDAR CTLWGIKPGK AHLERGDFRH NQHILEALRR ADVILVNNKA 

       430        440        450        460        470        480 
FTSSLNDDLT RMFLDLKPGA KIVSLKSFVA EKNNNHNIND VGSRILDVEE CTYPEGYVSW 

       490 
TNAGGSYFIS TRKQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG698912 Genomic DNA. Translation: EEU39139.1.
RefSeqXP_003044852.1. XM_003044806.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiNechaT70385; NechaP70385; NechaG70385.
GeneID9672034.
KEGGnhe:NECHADRAFT_70385.

Phylogenomic databases

KOK11427.
OrthoDBEOG7KH9VN.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7Z9Q2_NECH7
AccessionPrimary (citable) accession number: C7Z9Q2
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)