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C7Z9Q2

- C7Z9Q2_NECH7

UniProt

C7Z9Q2 - C7Z9Q2_NECH7

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

NECHADRAFT_70385

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei361 – 3611S-adenosyl-L-methionineUniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    ORF Names:NECHADRAFT_70385Imported
    OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)Imported
    Taxonomic identifieri660122 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
    ProteomesiUP000005206: Unassembled WGS sequence

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni311 – 3144S-adenosyl-L-methionine bindingUniRule annotation
    Regioni335 – 34410S-adenosyl-L-methionine bindingUniRule annotation
    Regioni397 – 3982S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

    Phylogenomic databases

    KOiK11427.
    OrthoDBiEOG7KH9VN.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C7Z9Q2-1 [UniParc]FASTAAdd to Basket

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    MRLFGGKNNK FKADPPKIRI EKVVVDRPAT KPKPKPKPAL SGSASRSSSS    50
    HRPSPKPLAR QASHSPYPSS SDEKRLERKR KASSVSRRSP ASDRIEFDKD 100
    SDGEDDGWMT LDSNKRQRKG TEDGFVDTNR KLRSVRAFKD RLDRRSFIHA 150
    VDVASLQHKC VPVMGAQKED VAIELQYPSL QPREKYELVW GKDKIDAVEA 200
    SIKVVRHVAE TYLTDDEAEP FTNPNGGIIR RLEKASNRNI QDLMGFKTAL 250
    REYNEKLLAL VEDGVISKNL DNMHELPQHL VAFILDQIYD RTVAPKVELL 300
    SKYENGTDYV YGELLHPFIS KILVEQTQMT SGQVFVDLGS GVGNVVLQAA 350
    LEIGCESWGC EMMENACNLG EAQKKEFDAR CTLWGIKPGK AHLERGDFRH 400
    NQHILEALRR ADVILVNNKA FTSSLNDDLT RMFLDLKPGA KIVSLKSFVA 450
    EKNNNHNIND VGSRILDVEE CTYPEGYVSW TNAGGSYFIS TRKQ 494
    Length:494
    Mass (Da):55,613
    Last modified:October 13, 2009 - v1
    Checksum:iFFAAEBC488817BED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG698912 Genomic DNA. Translation: EEU39139.1.
    RefSeqiXP_003044852.1. XM_003044806.1.

    Genome annotation databases

    EnsemblFungiiNechaT70385; NechaP70385; NechaG70385.
    GeneIDi9672034.
    KEGGinhe:NECHADRAFT_70385.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG698912 Genomic DNA. Translation: EEU39139.1 .
    RefSeqi XP_003044852.1. XM_003044806.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii NechaT70385 ; NechaP70385 ; NechaG70385 .
    GeneIDi 9672034.
    KEGGi nhe:NECHADRAFT_70385.

    Phylogenomic databases

    KOi K11427.
    OrthoDBi EOG7KH9VN.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVIImported.

    Entry informationi

    Entry nameiC7Z9Q2_NECH7
    AccessioniPrimary (citable) accession number: C7Z9Q2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3