C7Z837 (AMPP2_NECH7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase NECHADRAFT_60613
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

NECHADRAFT_60613

Organism

Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi) [Reference proteome]

Taxonomic identifier

660122 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Hypocreomycetidae › Hypocreales › Nectriaceae › Nectria › Nectria haematococca complex › Nectria haematococca › Fusarium solani subsp. pisi

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 462	462	Probable Xaa-Pro aminopeptidase NECHADRAFT_60613		PRO_0000411839
Sites
	Metal binding	259	1	Manganese 2 By similarity
	Metal binding	270	1	Manganese 1 By similarity
	Metal binding	270	1	Manganese 2 By similarity
	Metal binding	393	1	Manganese 1 By similarity
	Metal binding	433	1	Manganese 1 By similarity
	Metal binding	433	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	C7Z837 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: 45DFA9BBD9E30C18	FASTA	462	51,879
	10 20 30 40 50 60 MVAEDFEAVL KAKYPSKSHA KRVVDLIREK IPNANGILYL ESRMTKLLED NDEPEPFRQR 70 80 90 100 110 120 RFFYYLTGCN LPDCYYIYDI QSSKSILFIP PIDPDSVIWS GLPLSIDEAL QKYDVDDVKL 130 140 150 160 170 180 TSELNATLAH LGQANPQSTA YAIANQVSDH VTFLEFEKKN FDALKEAIEV SRVVKDEFEV 190 200 210 220 230 240 AMIRKANHVS DIAHRAVLEK AKTAVNEREF EAAFLERCVA HGAKEMAYHP IAASGRAAAT 250 260 270 280 290 300 LHYVTNESPL EGKLNLLMDA GAEWNNYAAD ITRTFPLSGK FSKESREIYE IVLKMQNDCI 310 320 330 340 350 360 AVLKEGVLWD DVHLLAHKIA IDGLLSIGIL KGDKDEILKG RTSAAFLPHG LGHYLGMDTH 370 380 390 400 410 420 DTGGNANYED KDKLFRYLRV RGNLPSGSVI TVEPGIYFCN FIIAPYLEDP VHSKFIDSAV 430 440 450 460 LDKYWDVGGV RIEDNILITK DGYENLTITP KEVDEIETLV SN

References

[1]

"The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion." Coleman J.J., Rounsley S.D., Rodriguez-Carres M., Kuo A., Wasmann C.C., Grimwood J., Schmutz J., Taga M., White G.J., Zhou S., Schwartz D.C., Freitag M., Ma L.-J., Danchin E.G.J., Henrissat B., Coutinho P.M., Nelson D.R., Straney D. , Napoli C.A., Barker B.M., Gribskov M., Rep M., Kroken S., Molnar I., Rensing C., Kennell J.C., Zamora J., Farman M.L., Selker E.U., Salamov A., Shapiro H., Pangilinan J., Lindquist E., Lamers C., Grigoriev I.V., Geiser D.M., Covert S.F., Temporini E., VanEtten H.D. PLoS Genet. 5:E1000618-E1000618(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG698911 Genomic DNA. Translation: EEU39803.1.
RefSeq	XP_003045516.1. XM_003045470.1.
3D structure databases
ProteinModelPortal	C7Z837.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	NechaT60613; NechaP60613; NechaG60613.
GeneID	9672417.
KEGG	nhe:NECHADRAFT_60613.
Phylogenomic databases
KO	K14213.
OrthoDB	EOG4J40RD.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_NECH7

Accession

Primary (citable) accession number: C7Z837

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	October 13, 2009
Last modified:	March 6, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program