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C7Z7V7

- MAP22_NECH7

UniProt

C7Z7V7 - MAP22_NECH7

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Protein

Methionine aminopeptidase 2-2

Gene
NECHADRAFT_93045
Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei211 – 2111Substrate By similarity
Metal bindingi232 – 2321Divalent metal cation 1 By similarity
Metal bindingi243 – 2431Divalent metal cation 1 By similarity
Metal bindingi243 – 2431Divalent metal cation 2; catalytic By similarity
Metal bindingi302 – 3021Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei310 – 3101Substrate By similarity
Metal bindingi335 – 3351Divalent metal cation 2; catalytic By similarity
Metal bindingi431 – 4311Divalent metal cation 1 By similarity
Metal bindingi431 – 4311Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal involved in protein maturation Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2-2 (EC:3.4.11.18)
Short name:
MAP 2-2
Short name:
MetAP 2-2
Alternative name(s):
Peptidase M
Gene namesi
ORF Names:NECHADRAFT_93045
OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Taxonomic identifieri660122 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
ProteomesiUP000005206: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Methionine aminopeptidase 2-2UniRule annotationPRO_0000407630Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC7Z7V7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi69 – 8416Lys-richUniRule annotationAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

KOiK01265.
OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7Z7V7-1 [UniParc]FASTAAdd to Basket

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MGAKISEDHP PQGNGGPLSN DPCSAGGEPR GAHLSRDGDG SVGDKGGDDD    50
DDDDEGVVGA VSLTEASDKK KKKKRKPKKK KAKKATHQSS PPRVPLSELF 100
TPGQYPTGEF LEYEDTNTAR TTAAELRALG RKQLEDPAFL DDYRRAAEVH 150
RQVRQWAQES VKPGQTLRDI ANGIEDGVRA LLGNQGLEPG DGLKSGMGFP 200
TGLCLNHETA HYTPNPGQKD VVLQYEDVMK VDFGVHINGW IVDSAFTMSF 250
DPTYDNLLAA VKDATNSGIK VNAAIQEAME SYEVEIAGKT YPVKPVRNIS 300
AHNIQHYRIH GGKSIPFIKN SDQTKMEEGE VFAIETFGTT GRGRLYDDVG 350
IYGYKLENGG PSPASLPFAS AKKLHKVIKE NFGNIVFCRR YLERLGQERY 400
LAGLNCLVSN GLLEAYEPLA DVKGSYSAQF EHTILLRESS KEILSRGSDY 450
Length:450
Mass (Da):49,173
Last modified:October 13, 2009 - v1
Checksum:i8584AFDFFCEB89B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG698911 Genomic DNA. Translation: EEU39759.1.
RefSeqiXP_003045472.1. XM_003045426.1.

Genome annotation databases

EnsemblFungiiNechaT93045; NechaP93045; NechaG93045.
GeneIDi9672634.
KEGGinhe:NECHADRAFT_93045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG698911 Genomic DNA. Translation: EEU39759.1 .
RefSeqi XP_003045472.1. XM_003045426.1.

3D structure databases

ProteinModelPortali C7Z7V7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii NechaT93045 ; NechaP93045 ; NechaG93045 .
GeneIDi 9672634.
KEGGi nhe:NECHADRAFT_93045.

Phylogenomic databases

KOi K01265.
OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI.

Entry informationi

Entry nameiMAP22_NECH7
AccessioniPrimary (citable) accession number: C7Z7V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: October 13, 2009
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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