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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei749Charge relay systemBy similarity1
Active sitei826Charge relay systemBy similarity1
Active sitei859Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERinech7-dapb. DPP4N_Peptidase_S9.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:NECHADRAFT_47100
OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Taxonomic identifieri660122 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
Proteomesi
  • UP000005206 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 85CytoplasmicSequence analysisAdd BLAST85
Transmembranei86 – 106Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini107 – 912VacuolarSequence analysisAdd BLAST806

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004121501 – 912Probable dipeptidyl-aminopeptidase BAdd BLAST912

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi344N-linked (GlcNAc...)Sequence analysis1
Glycosylationi808N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliC7YYG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiC7YYG9.
KOiK01282.
OrthoDBiEOG092C0PZJ.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

C7YYG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSALSPEGD RRYSDDSLSS VSTTSLVFER IQEKTEMDAD NDKEKDPRAL
60 70 80 90 100
DDEDPLRDED DLETGPFLGP GASLHREPMD RGLRRILIIV AVVFIGGWLA
110 120 130 140 150
GLGIFIASGS YHHESDTEHD PDANSRGSGK SLSMDQLFDG TWSPKYHSIS
160 170 180 190 200
WIAGPKGEDG LLLEVGASNK PYIVVEDIRS DKNVATRDDA EPKASNSRTL
210 220 230 240 250
MEHPYFEYDG KQYSPSWSEP SPDLTKVLLG VDRKKNWRHS FSAIYFVLDV
260 270 280 290 300
KTQEAEPLVP DQVDARIQLA SWSPKSDAVS FTRENNLYIR RLTGDKDVTQ
310 320 330 340 350
ITKDGGPEYF YGIPDWVYEE EVFSGRSATW WSDDGKYLAF LRTNETGVPE
360 370 380 390 400
YPVQFFIERP SGTTPEDGEE AYPEVEQIKY PKAGAHNPVV DLQFYDIGKK
410 420 430 440 450
DTFSVEIDGA FADDDRIINN LLWAGDKAIV KQTNRVSDVL KVVLVDVPSR
460 470 480 490 500
KGKTINTINI NEIDGGWFEI SHKMTYIPAD PKNGREHDGY VDSVIHEGYD
510 520 530 540 550
HLAYFTPLDN SEPIMLTKGN WEVDDAPSAV DLANNLVYFI AAKESSIQRH
560 570 580 590 600
VYSVKLDGSD LQALTDPKTE AYYDASFSKG AGFVFLSYRG PKVPTQKVIS
610 620 630 640 650
TPVSASSYER IIEDNAELAD RARRHELPIL KYGTLDLDTG VKVNYVERRP
660 670 680 690 700
PHFDAKKQYP VLFHQYSGPG SQSVTKRFAV DFQAYVAAAL GYLVITVDPR
710 720 730 740 750
GTGFLGRKHR VTVRSKLGVH EAHDHIAAAA SFASRPYVDA ERLAIWGWSY
760 770 780 790 800
GGFTTLKTLE QDAGRTFSYG MAVAPVTDWR FYDSIYTERY MRTPQDNPDG
810 820 830 840 850
YDLSKVANAT ALGENKRFLL MHGVADDNVH FQNSLTLLDD LDLAGVENYD
860 870 880 890 900
VHVFPDSDHS IYFHNGNRIV YDKLRNWLIN AFNGEWLKVS NPQPQKDPVE
910
KEKRHMVPQA LV
Length:912
Mass (Da):102,536
Last modified:October 13, 2009 - v1
Checksum:i316574CA966658A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG698903 Genomic DNA. Translation: EEU43005.1.
RefSeqiXP_003048718.1. XM_003048672.1.

Genome annotation databases

EnsemblFungiiNechaT47100; NechaP47100; NechaG47100.
GeneIDi9665490.
KEGGinhe:NECHADRAFT_47100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG698903 Genomic DNA. Translation: EEU43005.1.
RefSeqiXP_003048718.1. XM_003048672.1.

3D structure databases

ProteinModelPortaliC7YYG9.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERinech7-dapb. DPP4N_Peptidase_S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiNechaT47100; NechaP47100; NechaG47100.
GeneIDi9665490.
KEGGinhe:NECHADRAFT_47100.

Phylogenomic databases

InParanoidiC7YYG9.
KOiK01282.
OrthoDBiEOG092C0PZJ.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDAPB_NECH7
AccessioniPrimary (citable) accession number: C7YYG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 13, 2009
Last modified: September 7, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.