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C7YYG9

- DAPB_NECH7

UniProt

C7YYG9 - DAPB_NECH7

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei749 – 7491Charge relay systemBy similarity
    Active sitei826 – 8261Charge relay systemBy similarity
    Active sitei859 – 8591Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:NECHADRAFT_47100
    OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
    Taxonomic identifieri660122 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
    ProteomesiUP000005206: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 912912Probable dipeptidyl-aminopeptidase BPRO_0000412150Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi808 – 8081N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliC7YYG9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8585CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini107 – 912806VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei86 – 10621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01282.
    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C7YYG9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSALSPEGD RRYSDDSLSS VSTTSLVFER IQEKTEMDAD NDKEKDPRAL    50
    DDEDPLRDED DLETGPFLGP GASLHREPMD RGLRRILIIV AVVFIGGWLA 100
    GLGIFIASGS YHHESDTEHD PDANSRGSGK SLSMDQLFDG TWSPKYHSIS 150
    WIAGPKGEDG LLLEVGASNK PYIVVEDIRS DKNVATRDDA EPKASNSRTL 200
    MEHPYFEYDG KQYSPSWSEP SPDLTKVLLG VDRKKNWRHS FSAIYFVLDV 250
    KTQEAEPLVP DQVDARIQLA SWSPKSDAVS FTRENNLYIR RLTGDKDVTQ 300
    ITKDGGPEYF YGIPDWVYEE EVFSGRSATW WSDDGKYLAF LRTNETGVPE 350
    YPVQFFIERP SGTTPEDGEE AYPEVEQIKY PKAGAHNPVV DLQFYDIGKK 400
    DTFSVEIDGA FADDDRIINN LLWAGDKAIV KQTNRVSDVL KVVLVDVPSR 450
    KGKTINTINI NEIDGGWFEI SHKMTYIPAD PKNGREHDGY VDSVIHEGYD 500
    HLAYFTPLDN SEPIMLTKGN WEVDDAPSAV DLANNLVYFI AAKESSIQRH 550
    VYSVKLDGSD LQALTDPKTE AYYDASFSKG AGFVFLSYRG PKVPTQKVIS 600
    TPVSASSYER IIEDNAELAD RARRHELPIL KYGTLDLDTG VKVNYVERRP 650
    PHFDAKKQYP VLFHQYSGPG SQSVTKRFAV DFQAYVAAAL GYLVITVDPR 700
    GTGFLGRKHR VTVRSKLGVH EAHDHIAAAA SFASRPYVDA ERLAIWGWSY 750
    GGFTTLKTLE QDAGRTFSYG MAVAPVTDWR FYDSIYTERY MRTPQDNPDG 800
    YDLSKVANAT ALGENKRFLL MHGVADDNVH FQNSLTLLDD LDLAGVENYD 850
    VHVFPDSDHS IYFHNGNRIV YDKLRNWLIN AFNGEWLKVS NPQPQKDPVE 900
    KEKRHMVPQA LV 912
    Length:912
    Mass (Da):102,536
    Last modified:October 13, 2009 - v1
    Checksum:i316574CA966658A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG698903 Genomic DNA. Translation: EEU43005.1.
    RefSeqiXP_003048718.1. XM_003048672.1.

    Genome annotation databases

    EnsemblFungiiNechaT47100; NechaP47100; NechaG47100.
    GeneIDi9665490.
    KEGGinhe:NECHADRAFT_47100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG698903 Genomic DNA. Translation: EEU43005.1 .
    RefSeqi XP_003048718.1. XM_003048672.1.

    3D structure databases

    ProteinModelPortali C7YYG9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii NechaT47100 ; NechaP47100 ; NechaG47100 .
    GeneIDi 9665490.
    KEGGi nhe:NECHADRAFT_47100.

    Phylogenomic databases

    KOi K01282.
    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI.

    Entry informationi

    Entry nameiDAPB_NECH7
    AccessioniPrimary (citable) accession number: C7YYG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3