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C7YTG9

- C7YTG9_NECH7

UniProt

C7YTG9 - C7YTG9_NECH7

Protein

Histone-lysine N-methyltransferase, H3 lysine-4 specific

Gene

SDG2101

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-4 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Gene namesi
    Name:SDG2101Imported
    ORF Names:NECHADRAFT_49470Imported
    OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)Imported
    Taxonomic identifieri660122 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
    ProteomesiUP000005206: Unassembled WGS sequence

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-KW
    2. Set1C/COMPASS complex Source: InterPro

    Keywords - Cellular componenti

    ChromosomeUniRule annotation, NucleusUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Component of the COMPASS (Set1C) complex.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Phylogenomic databases

    KOiK11422.
    OrthoDBiEOG7P8PH3.

    Family and domain databases

    InterProiIPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTiSM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C7YTG9-1 [UniParc]FASTAAdd to Basket

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    MTRPPGASFA QFFPTAPKVK AQAQSRADRD RDRDRPKTTS SSASINGGAS     50
    DPTPASAGFD AHANASAQPA PGPNGHLAVS DTLSAHPDDN GSPLADIPST 100
    VDSASSYSSA ASSIFSTSAR HGAAATATSS RLPTSSLTPI ASKDSPSNSS 150
    ATAPTKPDMS ASLAADRAAR QSSHNSPAVG PNGSISDGPL AIERPPARDP 200
    MPSVKGLKCT YDPLLDRVHN KSVSRNAKPT YKEFGRDDDA PPTDPRLSKP 250
    GGRLGYINTD YYLPKARLRP APENIKPYPY DPKTSIGPGP PTQIVVTRYN 300
    PLVPFSKVTA IFATFGEIAE SSNKMHPETG SYLGFATIRY RDSKRPDRPR 350
    VSAIDAARRA VRTRGIKVDA DVVRVDYDPE GRRSRRMLEE HLRREKERME 400
    KKEKERLAQA VQAPPIGPKS TPASNFTRPP PTAPKGPAAQ RPAGAPSTPQ 450
    PTTTPVQPKG HAAVEVKNLA SQLTDDPYIY IAGDSVPVLT SIVPHMKKRL 500
    KNYGFEDIRL DKSGYYIVFR NSFTGKSEAE RCFRAVNHTE FFNYDMTMQL 550
    CLPRPRRSDE SPERRRQASA SPDRKPRGET GQRDEKDRRR REEEADLEEE 600
    KKQRAKNFDP VIEAVEVVRR EMTEHLIRHI RTKVAAPFLS EFLDPANHVA 650
    KRRKLNIEHP DDIEEIPSIE DGNDSSRVGT PNSRADPIER RTGRLEPKAL 700
    PRIRKTKVKG QAQRSAFIDP FARQRPVARN AFRSLHHRLR SLDSDVESDD 750
    DTDTRALLAR ETEEPESRPR SRMSTDDEAS KDDFASWGPG EDDSMTEASF 800
    HITDPLISRK RKLDASVETA FKRQKKSDEE LFGVKLGQLG TGFVAREDSV 850
    DIIPEPETGD DLESRVSRSE TPASVIGKTL KKKPAKAKKK TKKAVFEERE 900
    ALKRQAETDS QRGDEDEVVE APKAEPKVEE KPPVAEPVPE PVVEKYDEKL 950
    LSTEPLTPAL VLPDGFKPDL SLFQGLALGV NDKPDVAKLS KRFAVKDIGD 1000
    PELWLWKRNR IRELNSTKGT LEKPVSIEGY YVPNPTGCAR TEGVKKILNS 1050
    EKSKYLPHHI KVQKARQERE ARFKKSGKDA AAAAAEAAKL AAEKLIAKGN 1100
    SRANRATNRR YVADLNDQKK TLGQDSDVFK FNQLKKRKKP VKFARSAIHN 1150
    WGLYAMENIA KDDMIIEYVG EEVRQQIAEI RENRYLKSGI GSSYLFRIDE 1200
    NTVIDATKKG GIARFINHSC MPNCTAKIIK VEGSKRIVIY ALRDIAMNEE 1250
    LTYDYKFERE IGSLDRIPCL CGTAACKGFL N 1281
    Length:1,281
    Mass (Da):142,018
    Last modified:October 13, 2009 - v1
    Checksum:i82B0188A5F8DC822
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG698900 Genomic DNA. Translation: EEU44617.1.
    RefSeqiXP_003050330.1. XM_003050284.1.

    Genome annotation databases

    EnsemblFungiiNechaT49470; NechaP49470; NechaG49470.
    GeneIDi9665737.
    KEGGinhe:NECHADRAFT_49470.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG698900 Genomic DNA. Translation: EEU44617.1 .
    RefSeqi XP_003050330.1. XM_003050284.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii NechaT49470 ; NechaP49470 ; NechaG49470 .
    GeneIDi 9665737.
    KEGGi nhe:NECHADRAFT_49470.

    Phylogenomic databases

    KOi K11422.
    OrthoDBi EOG7P8PH3.

    Family and domain databases

    InterProi IPR024657. COMPASS_Set1_N-SET.
    IPR017111. Hist_H3-K4_MeTrfase_1_fun.
    IPR003616. Post-SET_dom.
    IPR024636. SET_assoc.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11764. N-SET. 1 hit.
    PF00856. SET. 1 hit.
    PF11767. SET_assoc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037104. Histone_H3-K4_mtfrase_Set1_fun. 1 hit.
    SMARTi SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS51572. SAM_MT43_1. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVIImported.

    Entry informationi

    Entry nameiC7YTG9_NECH7
    AccessioniPrimary (citable) accession number: C7YTG9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3