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C7YSA6

- C7YSA6_NECH7

UniProt

C7YSA6 - C7YSA6_NECH7

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Protein
Isocitrate dehydrogenase [NADP]
Gene
NECHADRAFT_100651
Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331Substrate By similarityUniRule annotation
Binding sitei138 – 1381NADP By similarity
Binding sitei165 – 1651Substrate By similarityUniRule annotation
Binding sitei188 – 1881Substrate By similarityUniRule annotation
Sitei195 – 1951Critical for catalysis By similarityUniRule annotation
Sitei267 – 2671Critical for catalysis By similarityUniRule annotation
Metal bindingi307 – 3071Magnesium or manganese By similarityUniRule annotation
Binding sitei315 – 3151NADP By similarity
Metal bindingi330 – 3301Magnesium or manganese By similarityUniRule annotation
Binding sitei383 – 3831NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi131 – 1333NADP By similarity
Nucleotide bindingi365 – 3706NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:NECHADRAFT_100651Imported
OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Taxonomic identifieri660122 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
ProteomesiUP000005206: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliC7YSA6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni150 – 1567Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.
OrthoDBiEOG7G4QQD.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7YSA6-1 [UniParc]FASTAAdd to Basket

« Hide

MPAVAFASAV PRSLLSSSLR RVAFASSSPI AVRPIRASFG AVQTISPFAV    50
RTMASAIPKI KVKNPVVELD GDEMTRIIWQ SIKDKFIYPY LDIDLKYYDL 100
GLEYRDETND QVTIDAAEAI KKYQVGVKCA TITPDEARVE EFKLKQMWLS 150
PNGTIRNALG GTVFREPIVI PRIPRLVPGW KKPIIIGRHA FGDQYRAKDA 200
VLPGPGKLSM VYTPEGGEPQ EIEVYQFKNG GGVAQTQYNT DESITGFAHA 250
SFKLALDKGL PLYMSTKNTI LKKYDGRFKD IFQELYDTQY KPEFEAKKIW 300
YEHRLIDDMV AQMVKSSGGY IMALKNYDGD VQSDIVAQGF GSLGLMTSVL 350
ITPDGKTFES EAAHGTVTRH YREHQKGNET STNPIASIFA WTRGLIQRGK 400
LDDQPEVVSF AESLEQACID TVDIDGVMTK DLALACGKTG REDYVTTTEY 450
LNAVERRMKN ILKEKL 466
Length:466
Mass (Da):52,027
Last modified:October 13, 2009 - v1
Checksum:iA7923FEAA03157C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG698899 Genomic DNA. Translation: EEU45600.1.
RefSeqiXP_003051313.1. XM_003051267.1.

Genome annotation databases

EnsemblFungiiNechaT100651; NechaP100651; NechaG100651.
GeneIDi9666174.
KEGGinhe:NECHADRAFT_100651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG698899 Genomic DNA. Translation: EEU45600.1 .
RefSeqi XP_003051313.1. XM_003051267.1.

3D structure databases

ProteinModelPortali C7YSA6.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii NechaT100651 ; NechaP100651 ; NechaG100651 .
GeneIDi 9666174.
KEGGi nhe:NECHADRAFT_100651.

Phylogenomic databases

KOi K00031.
OrthoDBi EOG7G4QQD.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI.

Entry informationi

Entry nameiC7YSA6_NECH7
AccessioniPrimary (citable) accession number: C7YSA6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: July 9, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi