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C7YSA6

- C7YSA6_NECH7

UniProt

C7YSA6 - C7YSA6_NECH7

Protein

Isocitrate dehydrogenase [NADP]

Gene

NECHADRAFT_100651

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei133 – 1331Substrate
    Binding sitei138 – 1381NADPUniRule annotation
    Binding sitei165 – 1651Substrate
    Binding sitei188 – 1881SubstrateUniRule annotation
    Sitei195 – 1951Critical for catalysisUniRule annotation
    Sitei267 – 2671Critical for catalysisUniRule annotation
    Metal bindingi307 – 3071Magnesium or manganeseUniRule annotation
    Binding sitei315 – 3151NADPUniRule annotation
    Metal bindingi330 – 3301Magnesium or manganeseUniRule annotation
    Binding sitei383 – 3831NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi131 – 1333NADPUniRule annotation
    Nucleotide bindingi365 – 3706NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:NECHADRAFT_100651Imported
    OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)Imported
    Taxonomic identifieri660122 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
    ProteomesiUP000005206: Unassembled WGS sequence

    Structurei

    3D structure databases

    ProteinModelPortaliC7YSA6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni150 – 1567Substrate binding

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.
    OrthoDBiEOG7G4QQD.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C7YSA6-1 [UniParc]FASTAAdd to Basket

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    MPAVAFASAV PRSLLSSSLR RVAFASSSPI AVRPIRASFG AVQTISPFAV    50
    RTMASAIPKI KVKNPVVELD GDEMTRIIWQ SIKDKFIYPY LDIDLKYYDL 100
    GLEYRDETND QVTIDAAEAI KKYQVGVKCA TITPDEARVE EFKLKQMWLS 150
    PNGTIRNALG GTVFREPIVI PRIPRLVPGW KKPIIIGRHA FGDQYRAKDA 200
    VLPGPGKLSM VYTPEGGEPQ EIEVYQFKNG GGVAQTQYNT DESITGFAHA 250
    SFKLALDKGL PLYMSTKNTI LKKYDGRFKD IFQELYDTQY KPEFEAKKIW 300
    YEHRLIDDMV AQMVKSSGGY IMALKNYDGD VQSDIVAQGF GSLGLMTSVL 350
    ITPDGKTFES EAAHGTVTRH YREHQKGNET STNPIASIFA WTRGLIQRGK 400
    LDDQPEVVSF AESLEQACID TVDIDGVMTK DLALACGKTG REDYVTTTEY 450
    LNAVERRMKN ILKEKL 466
    Length:466
    Mass (Da):52,027
    Last modified:October 13, 2009 - v1
    Checksum:iA7923FEAA03157C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG698899 Genomic DNA. Translation: EEU45600.1.
    RefSeqiXP_003051313.1. XM_003051267.1.

    Genome annotation databases

    EnsemblFungiiNechaT100651; NechaP100651; NechaG100651.
    GeneIDi9666174.
    KEGGinhe:NECHADRAFT_100651.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG698899 Genomic DNA. Translation: EEU45600.1 .
    RefSeqi XP_003051313.1. XM_003051267.1.

    3D structure databases

    ProteinModelPortali C7YSA6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii NechaT100651 ; NechaP100651 ; NechaG100651 .
    GeneIDi 9666174.
    KEGGi nhe:NECHADRAFT_100651.

    Phylogenomic databases

    KOi K00031.
    OrthoDBi EOG7G4QQD.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVIImported.

    Entry informationi

    Entry nameiC7YSA6_NECH7
    AccessioniPrimary (citable) accession number: C7YSA6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3