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C7YSA6 (C7YSA6_NECH7) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding131 – 1333NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding365 – 3706NADP By similarity PIRSR PIRSR000108-4
Region150 – 1567Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding3071Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding3301Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site1331Substrate By similarity PIRSR PIRSR000108-2
Binding site1381NADP By similarity PIRSR PIRSR000108-4
Binding site1651Substrate By similarity PIRSR PIRSR000108-2
Binding site1881Substrate By similarity PIRSR PIRSR000108-2
Binding site3151NADP By similarity PIRSR PIRSR000108-4
Binding site3831NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1951Critical for catalysis By similarity
Site2671Critical for catalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
C7YSA6 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: A7923FEAA03157C7

FASTA46652,027
        10         20         30         40         50         60 
MPAVAFASAV PRSLLSSSLR RVAFASSSPI AVRPIRASFG AVQTISPFAV RTMASAIPKI 

        70         80         90        100        110        120 
KVKNPVVELD GDEMTRIIWQ SIKDKFIYPY LDIDLKYYDL GLEYRDETND QVTIDAAEAI 

       130        140        150        160        170        180 
KKYQVGVKCA TITPDEARVE EFKLKQMWLS PNGTIRNALG GTVFREPIVI PRIPRLVPGW 

       190        200        210        220        230        240 
KKPIIIGRHA FGDQYRAKDA VLPGPGKLSM VYTPEGGEPQ EIEVYQFKNG GGVAQTQYNT 

       250        260        270        280        290        300 
DESITGFAHA SFKLALDKGL PLYMSTKNTI LKKYDGRFKD IFQELYDTQY KPEFEAKKIW 

       310        320        330        340        350        360 
YEHRLIDDMV AQMVKSSGGY IMALKNYDGD VQSDIVAQGF GSLGLMTSVL ITPDGKTFES 

       370        380        390        400        410        420 
EAAHGTVTRH YREHQKGNET STNPIASIFA WTRGLIQRGK LDDQPEVVSF AESLEQACID 

       430        440        450        460 
TVDIDGVMTK DLALACGKTG REDYVTTTEY LNAVERRMKN ILKEKL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG698899 Genomic DNA. Translation: EEU45600.1.
RefSeqXP_003051313.1. XM_003051267.1.

3D structure databases

ProteinModelPortalC7YSA6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiNechaT100651; NechaP100651; NechaG100651.
GeneID9666174.
KEGGnhe:NECHADRAFT_100651.

Phylogenomic databases

KOK00031.
OrthoDBEOG7G4QQD.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7YSA6_NECH7
AccessionPrimary (citable) accession number: C7YSA6
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 13, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)