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Protein

Isocitrate dehydrogenase [NADP]

Gene

NECHADRAFT_100651

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133SubstrateUniRule annotation1
Binding sitei138NADPUniRule annotation1
Binding sitei165SubstrateUniRule annotation1
Binding sitei188SubstrateUniRule annotation1
Sitei195Critical for catalysisUniRule annotation1
Sitei267Critical for catalysisUniRule annotation1
Metal bindingi307Magnesium or manganeseUniRule annotation1
Binding sitei315NADPUniRule annotation1
Metal bindingi330Magnesium or manganeseUniRule annotation1
Binding sitei383NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi131 – 133NADPUniRule annotation3
Nucleotide bindingi365 – 370NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:NECHADRAFT_100651Imported
OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)Imported
Taxonomic identifieri660122 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
Proteomesi
  • UP000005206 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliC7YSA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 454Iso_dhInterPro annotationAdd BLAST390

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 156Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

InParanoidiC7YSA6.
KOiK00031.
OrthoDBiEOG092C2D51.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7YSA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAVAFASAV PRSLLSSSLR RVAFASSSPI AVRPIRASFG AVQTISPFAV
60 70 80 90 100
RTMASAIPKI KVKNPVVELD GDEMTRIIWQ SIKDKFIYPY LDIDLKYYDL
110 120 130 140 150
GLEYRDETND QVTIDAAEAI KKYQVGVKCA TITPDEARVE EFKLKQMWLS
160 170 180 190 200
PNGTIRNALG GTVFREPIVI PRIPRLVPGW KKPIIIGRHA FGDQYRAKDA
210 220 230 240 250
VLPGPGKLSM VYTPEGGEPQ EIEVYQFKNG GGVAQTQYNT DESITGFAHA
260 270 280 290 300
SFKLALDKGL PLYMSTKNTI LKKYDGRFKD IFQELYDTQY KPEFEAKKIW
310 320 330 340 350
YEHRLIDDMV AQMVKSSGGY IMALKNYDGD VQSDIVAQGF GSLGLMTSVL
360 370 380 390 400
ITPDGKTFES EAAHGTVTRH YREHQKGNET STNPIASIFA WTRGLIQRGK
410 420 430 440 450
LDDQPEVVSF AESLEQACID TVDIDGVMTK DLALACGKTG REDYVTTTEY
460
LNAVERRMKN ILKEKL
Length:466
Mass (Da):52,027
Last modified:October 13, 2009 - v1
Checksum:iA7923FEAA03157C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG698899 Genomic DNA. Translation: EEU45600.1.
RefSeqiXP_003051313.1. XM_003051267.1.

Genome annotation databases

EnsemblFungiiNechaT100651; NechaP100651; NechaG100651.
GeneIDi9666174.
KEGGinhe:NECHADRAFT_100651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG698899 Genomic DNA. Translation: EEU45600.1.
RefSeqiXP_003051313.1. XM_003051267.1.

3D structure databases

ProteinModelPortaliC7YSA6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiNechaT100651; NechaP100651; NechaG100651.
GeneIDi9666174.
KEGGinhe:NECHADRAFT_100651.

Phylogenomic databases

InParanoidiC7YSA6.
KOiK00031.
OrthoDBiEOG092C2D51.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC7YSA6_NECH7
AccessioniPrimary (citable) accession number: C7YSA6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 7, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.