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C7YS77

- MAP21_NECH7

UniProt

C7YS77 - MAP21_NECH7

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Protein

Methionine aminopeptidase 2-1

Gene

NECHADRAFT_61369

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei198 – 1981SubstrateUniRule annotation
Metal bindingi218 – 2181Divalent metal cation 1UniRule annotation
Metal bindingi229 – 2291Divalent metal cation 1UniRule annotation
Metal bindingi229 – 2291Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi298 – 2981Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation
Binding sitei306 – 3061SubstrateUniRule annotation
Metal bindingi331 – 3311Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi426 – 4261Divalent metal cation 1UniRule annotation
Metal bindingi426 – 4261Divalent metal cation 2; catalyticUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal involved in protein maturation Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2-1UniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAP 2-1UniRule annotation
Short name:
MetAP 2-1UniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
ORF Names:NECHADRAFT_61369
OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Taxonomic identifieri660122 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
ProteomesiUP000005206: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Methionine aminopeptidase 2-1PRO_0000407608Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC7YS77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi61 – 7313Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.UniRule annotation

Phylogenomic databases

InParanoidiC7YS77.
KOiK01265.
OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
PROSITEiPS01202. MAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7YS77-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAQVPTEAL KELNVAEGSQ KPGATAQSKT DAAGDEHGGD DSEDEADGHV
60 70 80 90 100
DGAAPTGEAT KKKKKRKPKK KKKHPTSQTD PPRVMISQLF PNKAYPKGEE
110 120 130 140 150
VEYKDENNYR TTNEEKRHLD NLNSDFLADF REAAEIHRQV RQWTQKTVKP
160 170 180 190 200
GQTLTEIAEG IENSVRALTG HDGLTEGDAM KAGMGFPCGL SLNHCAAHYT
210 220 230 240 250
PNAGNKMVLQ QEDVMKVDFG VHVNGRIVDS AFTMAFEPKY DNLLQAVKDA
260 270 280 290 300
TNAGIREAGI DARVGEIGGV IQEVMESFEV EIDGTTYPVK SIRNLTGHNI
310 320 330 340 350
LPYSIHGTKA VPIVKSNDQT KMEEGDVFAI ETFGSTGNGY VRDDMETSHY
360 370 380 390 400
AKRGDSQHVD LRLSSAKNLL NVINKNFGTL PFCRRYLDRL GSDKYLLGLN
410 420 430 440
SLVNSGIVEA YPPLCDKKGS YTAQFEHTIL IRPTVKEVVS RGDDY
Length:445
Mass (Da):48,913
Last modified:October 13, 2009 - v1
Checksum:iDE571372BF9B8036
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG698899 Genomic DNA. Translation: EEU45587.1.
RefSeqiXP_003051300.1. XM_003051254.1.

Genome annotation databases

EnsemblFungiiNechaT61369; NechaP61369; NechaG61369.
GeneIDi9668147.
KEGGinhe:NECHADRAFT_61369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG698899 Genomic DNA. Translation: EEU45587.1 .
RefSeqi XP_003051300.1. XM_003051254.1.

3D structure databases

ProteinModelPortali C7YS77.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii NechaT61369 ; NechaP61369 ; NechaG61369 .
GeneIDi 9668147.
KEGGi nhe:NECHADRAFT_61369.

Phylogenomic databases

InParanoidi C7YS77.
KOi K01265.
OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR018349. Pept_M24A_MAP2_BS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
PROSITEi PS01202. MAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI.

Entry informationi

Entry nameiMAP21_NECH7
AccessioniPrimary (citable) accession number: C7YS77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: October 13, 2009
Last modified: November 26, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3