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C7YRS6

- KEX1_NECH7

UniProt

C7YRS6 - KEX1_NECH7

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei184 – 1841By similarity
Active sitei379 – 3791By similarity
Active sitei441 – 4411By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:NECHADRAFT_69476
OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Taxonomic identifieri660122 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
ProteomesiUP000005206: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 613586Pheromone-processing carboxypeptidase KEX1PRO_0000411928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi430 – 4301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi490 – 4901N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 513486LumenalSequence AnalysisAdd
BLAST
Topological domaini535 – 61379CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei514 – 53421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiC7YRS6.
KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C7YRS6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFLSIPSPR RWAALLSLSL GPILGAADAT SNSAADYYVR DLPGLPKDGP
60 70 80 90 100
NIKMHAGHIE VTPESHGNLF FWHFENQHIA DKQRTVIWIN GGPGCSSEDG
110 120 130 140 150
AMMEIGPYRL KDKENLYYNN GSWGEFANLL FVDNPVGTGY SLVDTNAYVK
160 170 180 190 200
ELDEMADQFI QFLEKWFALF PQYDRDDIYI AGESYAGQHI PYIAKAILDR
210 220 230 240 250
NKKNPSKAWN LQGLLIGNGW ISPVDQYPAY ISFAHEKGII EKGSDNDKKL
260 270 280 290 300
QSALRGCERV IASSPGRVDY GECEEILKNI LELTRDGNKC INMYDVRLTD
310 320 330 340 350
TYPSCGMNWP PDLEYLTPYL GRKDVVDALH VTSMKSTGWK ECSGAVGGAF
360 370 380 390 400
TARNSKPAVE LLPDLLKEVP VLLFSGAEDF ICNHLGTEEL ISKLEWNGGK
410 420 430 440 450
GFEVTPGNWA PRRDWTFEGE TAGFWQEARN LTYVLIYNSS HMVPFDLPRR
460 470 480 490 500
SRDMLDRFMG VDISNIGGDP TDSRIDGEKG PETTVGGASN KTQSAAQDHQ
510 520 530 540 550
KQLDEAKWAA YQKSGEVVLV IVIIAAIAWG YFVWRERRKG AAYHALANHD
560 570 580 590 600
NNSHSNGFRA KSQPGDLESA AFDESELDDL HGSTPATATS ARFPVNRNDT
610
REKFVTKYAE PSS
Length:613
Mass (Da):68,205
Last modified:October 13, 2009 - v1
Checksum:iC8B75F63C38D4CB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG698899 Genomic DNA. Translation: EEU45125.1.
RefSeqiXP_003050838.1. XM_003050792.1.

Genome annotation databases

EnsemblFungiiNechaT69476; NechaP69476; NechaG69476.
GeneIDi9667997.
KEGGinhe:NECHADRAFT_69476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG698899 Genomic DNA. Translation: EEU45125.1 .
RefSeqi XP_003050838.1. XM_003050792.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii NechaT69476 ; NechaP69476 ; NechaG69476 .
GeneIDi 9667997.
KEGGi nhe:NECHADRAFT_69476.

Phylogenomic databases

InParanoidi C7YRS6.
KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI.

Entry informationi

Entry nameiKEX1_NECH7
AccessioniPrimary (citable) accession number: C7YRS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: October 13, 2009
Last modified: October 29, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3