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C7YQJ2

- CBPYA_NECH7

UniProt

C7YQJ2 - CBPYA_NECH7

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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei265 – 2651PROSITE-ProRule annotation
Active sitei457 – 4571PROSITE-ProRule annotation
Active sitei514 – 5141PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. phytochelatin biosynthetic process Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:NECHADRAFT_100110
OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Taxonomic identifieri660122 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
ProteomesiUP000005206: Unassembled WGS sequence

Subcellular locationi

Vacuole By similarity

GO - Cellular componenti

  1. fungal-type vacuole Source: EnsemblFungi
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Propeptidei18 – 124107By similarityPRO_0000407455Add
BLAST
Chaini125 – 537413Carboxypeptidase Y homolog APRO_0000407456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi178 ↔ 418By similarity
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi312 ↔ 326By similarity
Disulfide bondi336 ↔ 359By similarity
Disulfide bondi343 ↔ 352By similarity
Disulfide bondi381 ↔ 388By similarity
Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiC7YQJ2.
KOiK13289.
OrthoDBiEOG7XDBR1.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C7YQJ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLSTSALVL GAASSAVAFD QKVLGDLKKP AIDLDLSSWL NFGEEITAEA
60 70 80 90 100
KAVWEEVSML APDAVEAFKK QVIGTKPKKA NRRPDNHWDH VVKGADVQSI
110 120 130 140 150
WVDKNNEKHR KVGGRLDNYN LRAKKVDPSK LGVDKVKQYS GYLDDEEQDK
160 170 180 190 200
HLFYWFFESR NDPENDPVVL WLNGGPGCSS LTGLFLELGP ASINKKIEIV
210 220 230 240 250
NNPWSWNNNA SVIFLDQPVN VGYSYSGGSV SNTVAAGKDI YALLTLFFHQ
260 270 280 290 300
FPEYAKQDFH IAGESYAGHY IPVFANEILS HEDRNINLKS VLIGNGLTDG
310 320 330 340 350
YTQYEYYRPM ACGEGGYPSV LSESECQSMD NALPRCQSLI KGCYESGSAW
360 370 380 390 400
SCVPASIYCN NAMMGPYQRT GRNVYDIRGN CEDSSNLCYS GLGYIAEYLN
410 420 430 440 450
RQDVQDALGA EVSSYDSCNM DINRNFLFAG DWMQPYHQVV PNLLEKIPVL
460 470 480 490 500
IYAGDADFIC NWLGNQAWTN KLEWPGHKDF KNADIKNLKV EGKEYGKIKT
510 520 530
SGNFTFMQIY GAGHMVPMDQ PEASSDFFNR WLGGEWF
Length:537
Mass (Da):60,161
Last modified:October 13, 2009 - v1
Checksum:i08BE047930A51F10
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG698898 Genomic DNA. Translation: EEU46033.1.
RefSeqiXP_003051746.1. XM_003051700.1.

Genome annotation databases

EnsemblFungiiNechaT100110; NechaP100110; NechaG100110.
GeneIDi9673570.
KEGGinhe:NECHADRAFT_100110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG698898 Genomic DNA. Translation: EEU46033.1 .
RefSeqi XP_003051746.1. XM_003051700.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii NechaT100110 ; NechaP100110 ; NechaG100110 .
GeneIDi 9673570.
KEGGi nhe:NECHADRAFT_100110.

Phylogenomic databases

InParanoidi C7YQJ2.
KOi K13289.
OrthoDBi EOG7XDBR1.

Family and domain databases

Gene3Di 3.40.50.1820. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI.

Entry informationi

Entry nameiCBPYA_NECH7
AccessioniPrimary (citable) accession number: C7YQJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: October 13, 2009
Last modified: October 29, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3