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Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).By similarity

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei265PROSITE-ProRule annotation1
Active sitei457PROSITE-ProRule annotation1
Active sitei514PROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

MEROPSiS10.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase Y homolog A (EC:3.4.16.5)
Gene namesi
Name:CPYA
ORF Names:NECHADRAFT_100110
OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Taxonomic identifieri660122 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
Proteomesi
  • UP000005206 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
PropeptideiPRO_000040745518 – 124By similarityAdd BLAST107
ChainiPRO_0000407456125 – 537Carboxypeptidase Y homolog AAdd BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi178 ↔ 418By similarity
Glycosylationi209N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi312 ↔ 326By similarity
Disulfide bondi336 ↔ 359By similarity
Disulfide bondi343 ↔ 352By similarity
Disulfide bondi381 ↔ 388By similarity
Glycosylationi503N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiC7YQJ2.
KOiK13289.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR008442. Propeptide_carboxypepY.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C7YQJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSTSALVL GAASSAVAFD QKVLGDLKKP AIDLDLSSWL NFGEEITAEA
60 70 80 90 100
KAVWEEVSML APDAVEAFKK QVIGTKPKKA NRRPDNHWDH VVKGADVQSI
110 120 130 140 150
WVDKNNEKHR KVGGRLDNYN LRAKKVDPSK LGVDKVKQYS GYLDDEEQDK
160 170 180 190 200
HLFYWFFESR NDPENDPVVL WLNGGPGCSS LTGLFLELGP ASINKKIEIV
210 220 230 240 250
NNPWSWNNNA SVIFLDQPVN VGYSYSGGSV SNTVAAGKDI YALLTLFFHQ
260 270 280 290 300
FPEYAKQDFH IAGESYAGHY IPVFANEILS HEDRNINLKS VLIGNGLTDG
310 320 330 340 350
YTQYEYYRPM ACGEGGYPSV LSESECQSMD NALPRCQSLI KGCYESGSAW
360 370 380 390 400
SCVPASIYCN NAMMGPYQRT GRNVYDIRGN CEDSSNLCYS GLGYIAEYLN
410 420 430 440 450
RQDVQDALGA EVSSYDSCNM DINRNFLFAG DWMQPYHQVV PNLLEKIPVL
460 470 480 490 500
IYAGDADFIC NWLGNQAWTN KLEWPGHKDF KNADIKNLKV EGKEYGKIKT
510 520 530
SGNFTFMQIY GAGHMVPMDQ PEASSDFFNR WLGGEWF
Length:537
Mass (Da):60,161
Last modified:October 13, 2009 - v1
Checksum:i08BE047930A51F10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG698898 Genomic DNA. Translation: EEU46033.1.
RefSeqiXP_003051746.1. XM_003051700.1.

Genome annotation databases

EnsemblFungiiNechaT100110; NechaP100110; NechaG100110.
GeneIDi9673570.
KEGGinhe:NECHADRAFT_100110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG698898 Genomic DNA. Translation: EEU46033.1.
RefSeqiXP_003051746.1. XM_003051700.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiNechaT100110; NechaP100110; NechaG100110.
GeneIDi9673570.
KEGGinhe:NECHADRAFT_100110.

Phylogenomic databases

InParanoidiC7YQJ2.
KOiK13289.
OrthoDBiEOG092C1EU7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR008442. Propeptide_carboxypepY.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF05388. Carbpep_Y_N. 1 hit.
PF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPYA_NECH7
AccessioniPrimary (citable) accession number: C7YQJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: October 13, 2009
Last modified: September 7, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.