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C7YQJ2

- CBPYA_NECH7

UniProt

C7YQJ2 - CBPYA_NECH7

Protein

Carboxypeptidase Y homolog A

Gene

CPYA

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei265 – 2651PROSITE-ProRule annotation
    Active sitei457 – 4571PROSITE-ProRule annotation
    Active sitei514 – 5141PROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. phytochelatin biosynthetic process Source: EnsemblFungi

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:CPYA
    ORF Names:NECHADRAFT_100110
    OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
    Taxonomic identifieri660122 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
    ProteomesiUP000005206: Unassembled WGS sequence

    Subcellular locationi

    Vacuole By similarity

    GO - Cellular componenti

    1. fungal-type vacuole Source: EnsemblFungi

    Keywords - Cellular componenti

    Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 124107By similarityPRO_0000407455Add
    BLAST
    Chaini125 – 537413Carboxypeptidase Y homolog APRO_0000407456Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi178 ↔ 418By similarity
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi312 ↔ 326By similarity
    Disulfide bondi336 ↔ 359By similarity
    Disulfide bondi343 ↔ 352By similarity
    Disulfide bondi381 ↔ 388By similarity
    Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    KOiK13289.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C7YQJ2-1 [UniParc]FASTAAdd to Basket

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    MRLSTSALVL GAASSAVAFD QKVLGDLKKP AIDLDLSSWL NFGEEITAEA    50
    KAVWEEVSML APDAVEAFKK QVIGTKPKKA NRRPDNHWDH VVKGADVQSI 100
    WVDKNNEKHR KVGGRLDNYN LRAKKVDPSK LGVDKVKQYS GYLDDEEQDK 150
    HLFYWFFESR NDPENDPVVL WLNGGPGCSS LTGLFLELGP ASINKKIEIV 200
    NNPWSWNNNA SVIFLDQPVN VGYSYSGGSV SNTVAAGKDI YALLTLFFHQ 250
    FPEYAKQDFH IAGESYAGHY IPVFANEILS HEDRNINLKS VLIGNGLTDG 300
    YTQYEYYRPM ACGEGGYPSV LSESECQSMD NALPRCQSLI KGCYESGSAW 350
    SCVPASIYCN NAMMGPYQRT GRNVYDIRGN CEDSSNLCYS GLGYIAEYLN 400
    RQDVQDALGA EVSSYDSCNM DINRNFLFAG DWMQPYHQVV PNLLEKIPVL 450
    IYAGDADFIC NWLGNQAWTN KLEWPGHKDF KNADIKNLKV EGKEYGKIKT 500
    SGNFTFMQIY GAGHMVPMDQ PEASSDFFNR WLGGEWF 537
    Length:537
    Mass (Da):60,161
    Last modified:October 13, 2009 - v1
    Checksum:i08BE047930A51F10
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG698898 Genomic DNA. Translation: EEU46033.1.
    RefSeqiXP_003051746.1. XM_003051700.1.

    Genome annotation databases

    EnsemblFungiiNechaT100110; NechaP100110; NechaG100110.
    GeneIDi9673570.
    KEGGinhe:NECHADRAFT_100110.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG698898 Genomic DNA. Translation: EEU46033.1 .
    RefSeqi XP_003051746.1. XM_003051700.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii NechaT100110 ; NechaP100110 ; NechaG100110 .
    GeneIDi 9673570.
    KEGGi nhe:NECHADRAFT_100110.

    Phylogenomic databases

    KOi K13289.
    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI.

    Entry informationi

    Entry nameiCBPYA_NECH7
    AccessioniPrimary (citable) accession number: C7YQJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3