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C7YLQ3

- MTAP_NECH7

UniProt

C7YLQ3 - MTAP_NECH7

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Protein
S-methyl-5'-thioadenosine phosphorylase
Gene
NECHADRAFT_67177
Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Phosphate By similarity
Sitei179 – 1791Important for substrate specificity By similarity
Binding sitei197 – 1971Substrate; via amide nitrogen By similarity
Binding sitei198 – 1981Phosphate By similarity
Sitei233 – 2331Important for substrate specificity By similarity

GO - Molecular functioni

  1. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP
  2. mRNA binding Source: EnsemblFungi
  3. phosphorylase activity Source: InterPro

GO - Biological processi

  1. L-methionine salvage from methylthioadenosine Source: UniProtKB-HAMAP
  2. glutamate biosynthetic process Source: EnsemblFungi
  3. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylase (EC:2.4.2.28)
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name:
MTA phosphorylase
Short name:
MTAP
Short name:
MTAPase
Gene namesi
ORF Names:NECHADRAFT_67177
OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Taxonomic identifieri660122 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
ProteomesiUP000005206: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307S-methyl-5'-thioadenosine phosphorylaseUniRule annotation
PRO_0000415129Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC7YLQ3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 632Phosphate binding By similarity
Regioni95 – 962Phosphate binding By similarity
Regioni221 – 2233Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

KOiK00772.
OrthoDBiEOG77DJGM.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7YLQ3-1 [UniParc]FASTAAdd to Basket

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MGDLPTTFDK PVHIAVIGGT GLGQLEGFEP IAALNPITPW GAPASPIQIL    50
SHKGVNVAFL ARHGIHHQFA PHEVPNRANI AALRHIGVRC VIAFSAVGSL 100
QEEIKPMDFV VPDQVIDRTK GVRPFTFFEG GVVGHVGFAD PFDAGLAKVV 150
KTCAEHMEGD GVVLHEKGTV IVMEGPQFST RAESHMYRSW GGSVINMSTL 200
PEAKLAREAE MAYQVIAMAT DYDCWHSFED VNVEMVGKYM KANSKNAKRL 250
VGAVLDRLAD LDNSDLVLAK HWQGASQGAV KFMTKPEGRD PEAMKRVEYL 300
FPGFWEE 307
Length:307
Mass (Da):33,543
Last modified:October 13, 2009 - v1
Checksum:i9323A88A26A7E0A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG698897 Genomic DNA. Translation: EEU47310.1.
RefSeqiXP_003053023.1. XM_003052977.1.

Genome annotation databases

EnsemblFungiiNechaT67177; NechaP67177; NechaG67177.
GeneIDi9663789.
KEGGinhe:NECHADRAFT_67177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG698897 Genomic DNA. Translation: EEU47310.1 .
RefSeqi XP_003053023.1. XM_003052977.1.

3D structure databases

ProteinModelPortali C7YLQ3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii NechaT67177 ; NechaP67177 ; NechaG67177 .
GeneIDi 9663789.
KEGGi nhe:NECHADRAFT_67177.

Phylogenomic databases

KOi K00772.
OrthoDBi EOG77DJGM.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI.

Entry informationi

Entry nameiMTAP_NECH7
AccessioniPrimary (citable) accession number: C7YLQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: October 13, 2009
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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