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C7YLQ3

- MTAP_NECH7

UniProt

C7YLQ3 - MTAP_NECH7

Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

NECHADRAFT_67177

Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

    Catalytic activityi

    S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei20 – 201PhosphateUniRule annotation
    Sitei179 – 1791Important for substrate specificityUniRule annotation
    Binding sitei197 – 1971Substrate; via amide nitrogenUniRule annotation
    Binding sitei198 – 1981PhosphateUniRule annotation
    Sitei233 – 2331Important for substrate specificityUniRule annotation

    GO - Molecular functioni

    1. mRNA binding Source: EnsemblFungi
    2. phosphorylase activity Source: InterPro
    3. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamate biosynthetic process Source: EnsemblFungi
    2. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
    3. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    UniPathwayiUPA00904; UER00873.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
    Alternative name(s):
    5'-methylthioadenosine phosphorylaseUniRule annotation
    Short name:
    MTA phosphorylaseUniRule annotation
    Short name:
    MTAPUniRule annotation
    Short name:
    MTAPaseUniRule annotation
    Gene namesi
    ORF Names:NECHADRAFT_67177
    OrganismiNectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)
    Taxonomic identifieri660122 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium solani species complex
    ProteomesiUP000005206: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307S-methyl-5'-thioadenosine phosphorylasePRO_0000415129Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliC7YLQ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni62 – 632Phosphate bindingUniRule annotation
    Regioni95 – 962Phosphate bindingUniRule annotation
    Regioni221 – 2233Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

    Phylogenomic databases

    KOiK00772.
    OrthoDBiEOG77DJGM.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01963. MTAP.
    InterProiIPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01694. MTAP. 1 hit.
    PROSITEiPS01240. PNP_MTAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C7YLQ3-1 [UniParc]FASTAAdd to Basket

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    MGDLPTTFDK PVHIAVIGGT GLGQLEGFEP IAALNPITPW GAPASPIQIL    50
    SHKGVNVAFL ARHGIHHQFA PHEVPNRANI AALRHIGVRC VIAFSAVGSL 100
    QEEIKPMDFV VPDQVIDRTK GVRPFTFFEG GVVGHVGFAD PFDAGLAKVV 150
    KTCAEHMEGD GVVLHEKGTV IVMEGPQFST RAESHMYRSW GGSVINMSTL 200
    PEAKLAREAE MAYQVIAMAT DYDCWHSFED VNVEMVGKYM KANSKNAKRL 250
    VGAVLDRLAD LDNSDLVLAK HWQGASQGAV KFMTKPEGRD PEAMKRVEYL 300
    FPGFWEE 307
    Length:307
    Mass (Da):33,543
    Last modified:October 13, 2009 - v1
    Checksum:i9323A88A26A7E0A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG698897 Genomic DNA. Translation: EEU47310.1.
    RefSeqiXP_003053023.1. XM_003052977.1.

    Genome annotation databases

    EnsemblFungiiNechaT67177; NechaP67177; NechaG67177.
    GeneIDi9663789.
    KEGGinhe:NECHADRAFT_67177.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG698897 Genomic DNA. Translation: EEU47310.1 .
    RefSeqi XP_003053023.1. XM_003052977.1.

    3D structure databases

    ProteinModelPortali C7YLQ3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii NechaT67177 ; NechaP67177 ; NechaG67177 .
    GeneIDi 9663789.
    KEGGi nhe:NECHADRAFT_67177.

    Phylogenomic databases

    KOi K00772.
    OrthoDBi EOG77DJGM.

    Enzyme and pathway databases

    UniPathwayi UPA00904 ; UER00873 .

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01963. MTAP.
    InterProi IPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01694. MTAP. 1 hit.
    PROSITEi PS01240. PNP_MTAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI.

    Entry informationi

    Entry nameiMTAP_NECH7
    AccessioniPrimary (citable) accession number: C7YLQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3