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C7V300 (C7V300_ENTFA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine--tRNA ligase 2 HAMAP MF_00176
EC=6.1.1.11 HAMAP MF_00176
Alternative name(s):
Seryl-tRNA synthetase 2 HAMAP MF_00176
Seryl-tRNA(Ser/Sec) synthetase 2 HAMAP MF_00176
Gene names
Name:serS2 HAMAP MF_00176
ORF Names:EFMG_02426 EMBL EEU90669.1
OrganismEnterococcus faecalis T11 EMBL EEU90669.1
Taxonomic identifier565640 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Enterococcaceae › Enterococcus

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) By similarity. HAMAP MF_00176

Catalytic activity

ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec). HAMAP MF_00176

ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). HAMAP MF_00176

Pathway

Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. HAMAP MF_00176

Subunit structure

Homodimer. The tRNA molecule binds across the dimer By similarity. HAMAP MF_00176

Subcellular location

Cytoplasm By similarity HAMAP MF_00176.

Domain

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding By similarity. HAMAP MF_00176

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. HAMAP MF_00176

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding262 – 2643ATP By similarity HAMAP MF_00176
Nucleotide binding349 – 3524ATP By similarity HAMAP MF_00176
Region231 – 2333Serine binding By similarity HAMAP MF_00176

Sites

Binding site2851Serine By similarity HAMAP MF_00176
Binding site3841Serine By similarity HAMAP MF_00176

Sequences

Sequence LengthMass (Da)Tools
C7V300 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: B70A4BB73C4C36AE

FASTA42348,123
        10         20         30         40         50         60 
MLDVKMMRQN FDEVKAKLQT RGVKEEILVE FLRLDESRRD LLVKVEEMKK YRNDVSAEIA 

        70         80         90        100        110        120 
QLKRNKEDAT AKIAEMKEVG GNIKALDAEI NAIDEELRGI TTTLPNLPDD SVPVGAGEEE 

       130        140        150        160        170        180 
NVEVRRWSEP RTFAFEPKPH WEVAENLGIL DFERGAKVAG SRFVYYKGLG ARLERALYNF 

       190        200        210        220        230        240 
MLDLHVYEHG YTEMITPYIV NDTAMFGTGQ FPKFKEDVFQ LQDTDLTLIP TAEVPLTNYY 

       250        260        270        280        290        300 
NNEILDGKDL PIYFTALSPS FRSEAGSAGR DTRGLIRLHQ FNKVEMVKFS DAEHSYEELE 

       310        320        330        340        350        360 
KMTNNAEEIL QKLGLPYRVM ALSTGDMGFS AAKTYDLEVW IPAQETYREI SSCSNCEDFQ 

       370        380        390        400        410        420 
ARRAMIRYRD ENDKVQYAHT LNGSGLAVGR TVAAILENYQ NEDGSVTVPE VLVPYMGNLT 


VIK

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		GG688644 Genomic DNA. Translation: EEU90669.1.

3D structure databases

ProteinModelPortalC7V300.
SMRC7V300. Positions 1-423.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

PATRIC26734548. VBIEntFae41231_1126.

Phylogenomic databases

OMAHANEILK.

Family and domain databases

HAMAPMF_00176. Ser_tRNA_synth_type1.
[Tree]
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR002317. Ser-tRNA-synth_IIa.
IPR015866. Ser-tRNA-synth_IIa_N.
IPR010978. tRNA-bd_arm.
[Graphical view]
Gene3DG3DSA:1.10.287.40. Ser-tRNA-synth_IIa_N. 1 hit.
PANTHERPTHR11778. tRNA-synt_ser. 1 hit.
PfamPF02403. Seryl_tRNA_N. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PIRSFPIRSF001529. Ser-tRNA-synth_IIa. 1 hit.
PRINTSPR00981. TRNASYNTHSER.
SUPFAMSSF46589. tRNA_binding_arm. 1 hit.
TIGRFAMsTIGR00414. SerS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7V300_ENTFA
AccessionPrimary (citable) accession number: C7V300
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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