C7TQ60 (C7TQ60_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Calcium channel voltage-dependent alpha1c subunit EMBL CAS06715.1

Gene names

Name:

Cacna1c EMBL CAS06715.1 MGI 103013

Organism

Mus musculus (Mouse) EMBL CAS06715.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2153 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification] RuleBase RU003808

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808 Ion channel Voltage-gated channel RuleBase RU003808
Gene Ontology (GO)
Biological_process	adult walking behavior Inferred from genetic interaction PubMed 9882694. Source: MGI calcium ion-dependent exocytosis Inferred from mutant phenotype PubMed 12881419. Source: MGI cellular calcium ion homeostasis Inferred from mutant phenotype PubMed 15132976. Source: MGI glucose homeostasis Inferred from mutant phenotype PubMed 12881419. Source: MGI growth hormone secretion Inferred from direct assay PubMed 1385406. Source: MGI insulin secretion Inferred from mutant phenotype PubMed 12881419. Source: MGI regulation of blood pressure Inferred from mutant phenotype PubMed 14609949. Source: MGI regulation of organ growth Inferred from mutant phenotype PubMed 15132976. Source: MGI regulation of vasoconstriction Inferred from mutant phenotype PubMed 14609949. Source: MGI smooth muscle contraction involved in micturition Inferred from mutant phenotype PubMed 15132976. Source: MGI synaptic transmission Inferred from mutant phenotype PubMed 16251435. Source: MGI visual learning Inferred from mutant phenotype PubMed 16251435. Source: MGI
Cellular_component	T-tubule Traceable author statement PubMed 11784029. Source: MGI Z disc Inferred from direct assay PubMed 19383796. Source: MGI caveolar macromolecular signaling complex Inferred from direct assay PubMed 16648270. Source: MGI dendritic shaft Inferred from direct assay PubMed 15090038. Source: MGI neuronal cell body Inferred from direct assay PubMed 15090038. Source: MGI voltage-gated calcium channel complex Traceable author statement PubMed 11296258. Source: MGI
Molecular_function	voltage-gated calcium channel activity Inferred from direct assay PubMed 1385406PubMed 16267232PubMed 7635187PubMed 7814415. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C7TQ60 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: CD9361C49CF42A10	FASTA	2,153	241,864
	10 20 30 40 50 60 MVNENTRMYV PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL SWQAAIDAAR 70 80 90 100 110 120 QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGGTTATRP PRALLCLTLK NPIRRACISI 130 140 150 160 170 180 VEWKPFEIII LLTIFANCVA LAIYIPFPED DSNATNSNLE RVEYLFLIIF TVEAFLKVIA 190 200 210 220 230 240 YGLLFHPNAY LRNGWNLLDF IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR 250 260 270 280 290 300 VLRPLRLVSG VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN 310 320 330 340 350 360 QEGIIDVPAE EDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA FAMLTVFQCI 370 380 390 400 410 420 TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV LGVLSGEFSK EREKAKARGD 430 440 450 460 470 480 FQKLREKQQL EEDLKGYLDW ITQAEDIDPE NEDEGMDEDK PRNRGAPAGL HDQKKGKFAW 490 500 510 520 530 540 FSHSTETHMS MPTSETESVN TENVAGGDIE GENCGARLAH RISKSKFSRY WRRWNRFCRR 550 560 570 580 590 600 KCRAAVKSNV FYWLVIFLVF LNTLTIASEH YNQPHWLTEV QDTANKALLA LFTAEMLLKM 610 620 630 640 650 660 YSLGLQAYFV SLFNRFDCFI VCGGILETIL VETKIMSPLG ISVLRCVRLL RIFKITRYWN 670 680 690 700 710 720 SLSNLVASLL NSVRSIASLL LLLFLFIIIF SLLGMQLFGG KFNFDEMQTR RSTFDNFPQS 730 740 750 760 770 780 LLTVFQILTG EDWNSVMYDG IMAYGGPSFP GMLVCIYFII LFICGNYILL NVFLAIAVDN 790 800 810 820 830 840 LADAESLTSA QKEEEEEKER KKLARTASPE KKQEVMEKPA VEESKEEKIE LKSITADGES 850 860 870 880 890 900 PPTTKINMDD LQPSENEDKS PHSNPDTAGE EDEEEPEMPV GPRPRPLSEL HLKEKAVPMP 910 920 930 940 950 960 EASAFFIFSP NNRFRLQCHR IVNDTIFTNL ILFFILLSSI SLAAEDPVQH TSFRNHILFY 970 980 990 1000 1010 1020 FDIVFTTIFT IEIALKMTAY GAFLHKGSFC RNYFNILDLL VVSVSLISFG IQSSAINVVK 1030 1040 1050 1060 1070 1080 ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIVIV TTLLQFMFAC IGVQLFKGKL 1090 1100 1110 1120 1130 1140 YTCSDSSKQT EAECKGNYIT YKDGEVDHPI IQPRSWENSK FDFDNVLAAM MALFTVSTFE 1150 1160 1170 1180 1190 1200 GWPELLYRSI DSHTEDKGPI YNYRVEISIF FIIYIIIIAF FMMNIFVGFV IVTFQEQGEQ 1210 1220 1230 1240 1250 1260 EYKNCELDKN QRQCVEYALK ARPLRRYIPK NQHQYKVWYV VNSTYFEYLM FVLILLNTIC 1270 1280 1290 1300 1310 1320 LAMQHYGQSC LFKIAMNILN MLFTGLFTVE MILKLIAFKP KGYFSDPWNV FDFLIVIGSI 1330 1340 1350 1360 1370 1380 IDVILSETNS AEENSRISIT FFRLFRVMRL VKLLSRGEGI RTLLWTFIKS FQALPYVALL 1390 1400 1410 1420 1430 1440 IVMLFFIYAV IGMQVFGKIA LNDTTEINRN NNFQTFPQAV LLLFRCATGE AWQDIMLACM 1450 1460 1470 1480 1490 1500 PGKKCAPESE PSNSTEGETP CGSSFAVFYF ISFYMLCAFL IINLFVAVIM DNFDYLTRDW 1510 1520 1530 1540 1550 1560 SILGPHHLDE FKRIWAEYDP EAKGRIKHLD VVTLLRRIQP PLGFGKLCPH RVACKRLVSM 1570 1580 1590 1600 1610 1620 NMPLNSDGTV MFNATLFALV RTALRIKTEG NLEQANEELR AIIKKIWKRT SMKLLDQVVP 1630 1640 1650 1660 1670 1680 PAGDDEVTVG KFYATFLIQE YFRKFKKRKE QGLVGKPSQR NALSLQAGLR TLHDIGPEIR 1690 1700 1710 1720 1730 1740 RAISGDLTAE EELDKAMKEA VSAASEDDIF RRAGGLFGNH VTYYQSDSRG NFPQTFATQR 1750 1760 1770 1780 1790 1800 PLHINKTGNN QADTESPSHE KLVDSTFTPS SYSSTGSNAN INNANNTALG RFPHPAGYSS 1810 1820 1830 1840 1850 1860 TVSTVEGHGP PLSPAVRVQE AAWKLSSKRC HSRESQGATV NQEIFPDETR SVRMSEEAEY 1870 1880 1890 1900 1910 1920 CSEPSLLSTD MFSYQEDEHR QLTCPEEDKR EIQPSPKRSF LRSASLGRRA SFHLECLKRQ 1930 1940 1950 1960 1970 1980 KDQGGDISQK TALPLHLVHH QALAVAGLSP LLQRSHSPTT FPRPCPTPPV TPGSRGRPLR 1990 2000 2010 2020 2030 2040 PIPTLRLEGA ESSEKLNSSF PSIHCSSWSE ETTACSGSSS MARRARPVSL TVPSQAGAPG 2050 2060 2070 2080 2090 2100 RQFHGSASSL VEAVLISEGL GQFAQDPKFI EVTTQELADA CDMTIEEMEN AADNILSGGA 2110 2120 2130 2140 2150 QQSPNGTLLP FVNCRDPGQD RAVAPEDESC AYALGRGRSE EALADSRSYV SNL

References

[1]	Link S.A.M. Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6N EMBL CAS06715.1. Tissue: Heart EMBL CAS06715.1.
[2]	"Diversity and developmental expression of L-type calcium channel ?2 proteins and their influence on calcium current in murine heart." Link S., Meissner M., Held B., Beck A., Weissgerber P., Freichel M., Flockerzi V. J. Biol. Chem. 0:0-0(2009) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6N EMBL CAS06715.1. Tissue: Heart EMBL CAS06715.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM872412 mRNA. Translation: CAS06715.1.
IPI	IPI00128362.
RefSeq	NP_001242929.1. NM_001256000.1.
UniGene	Mm.436656.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	12288.
KEGG	mmu:12288.
UCSC	uc012erg.1. mouse.
Organism-specific databases
CTD	775.
MGI	MGI:103013. Cacna1c.
Phylogenomic databases
KO	K04850.
Family and domain databases
InterPro	IPR005821. Ion_trans_dom. IPR014873. VDCC_a1su_IQ. IPR005451. VDCC_L_a1csu. IPR005446. VDCC_L_a1su. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF47. PTHR10037:SF47. 1 hit.
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01630. LVDCCALPHA1. PR01635. LVDCCALPHA1C.
SMART	SM01062. Ca_chan_IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CACNA1C. mouse.
NextBio	280766.
SOURCE	Search...

Entry information

Entry name

C7TQ60_MOUSE

Accession

Primary (citable) accession number: C7TQ60

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	April 3, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)