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C7TN60

- C7TN60_LACRL

UniProt

C7TN60 - C7TN60_LACRL

Protein

Argininosuccinate synthase

Gene

argG

Organism
Lactobacillus rhamnosus (strain Lc 705)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei86 – 861CitrullineUniRule annotation
    Binding sitei116 – 1161ATP; via amide nitrogenUniRule annotation
    Binding sitei118 – 1181AspartateUniRule annotation
    Binding sitei122 – 1221AspartateUniRule annotation
    Binding sitei122 – 1221CitrullineUniRule annotation
    Binding sitei123 – 1231AspartateUniRule annotation
    Binding sitei126 – 1261CitrullineUniRule annotation
    Binding sitei174 – 1741CitrullineUniRule annotation
    Binding sitei259 – 2591CitrullineUniRule annotation
    Binding sitei271 – 2711CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 169ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLRHA568704:GHIC-1433-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotationImported
    Ordered Locus Names:LC705_02805Imported
    OrganismiLactobacillus rhamnosus (strain Lc 705)Imported
    Taxonomic identifieri568704 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000000956: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi568704.LC705_02805.

    Structurei

    3D structure databases

    ProteinModelPortaliC7TN60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C7TN60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEKIVLAYS GGLDTSVAIP WLMDKGYEVI AVVLNVGQPD ADFDAIQQKA    50
    LKVGAIDSIV VDAQDEFADH YVAPVIKANA LYEGDYPLVS ALSRPLIIEH 100
    LVKIAHAQNA TAIAHGSTGK GNDQVRFEAA IHALDPEMKI EAPIRDFHWS 150
    REEEIDYAKE HHVPVPIGKK SPYSIDANLW GRANEAGILE NPWNQAPDDA 200
    WGMTVAPEAA PDKPTFLDLT FQQGVPVALN GNPMPLAAMI KQLNQIAGAN 250
    GIGRIDKIEN RLVGIKSREV YEAPAAAVLM TAHHDLENLT LERDVQHFKP 300
    TIENKLTNMI YEAQWISPLF DALMAFIDKT QAVVNGTVKM KLYKGSAVPV 350
    ARQSTHNSLY DEDLATYTSA DSFDQEAAAG FIKLWTLPTT VFEQVNHVHS 400
    EEKQHD 406
    Length:406
    Mass (Da):44,672
    Last modified:October 13, 2009 - v1
    Checksum:i76D686C3FF317638
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM179323 Genomic DNA. Translation: CAR91644.1.
    RefSeqiYP_003175495.1. NC_013199.1.

    Genome annotation databases

    EnsemblBacteriaiCAR91644; CAR91644; LC705_02805.
    GeneIDi8432833.
    KEGGilrl:LC705_02805.
    PATRICi22272438. VBILacRha58455_2602.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM179323 Genomic DNA. Translation: CAR91644.1 .
    RefSeqi YP_003175495.1. NC_013199.1.

    3D structure databases

    ProteinModelPortali C7TN60.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 568704.LC705_02805.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR91644 ; CAR91644 ; LC705_02805 .
    GeneIDi 8432833.
    KEGGi lrl:LC705_02805.
    PATRICi 22272438. VBILacRha58455_2602.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci LRHA568704:GHIC-1433-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Lc 705Imported.

    Entry informationi

    Entry nameiC7TN60_LACRL
    AccessioniPrimary (citable) accession number: C7TN60
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3