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C7TN60

- C7TN60_LACRL

UniProt

C7TN60 - C7TN60_LACRL

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Lactobacillus rhamnosus (strain Lc 705)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861CitrullineUniRule annotation
Binding sitei116 – 1161ATP; via amide nitrogenUniRule annotation
Binding sitei118 – 1181AspartateUniRule annotation
Binding sitei122 – 1221AspartateUniRule annotation
Binding sitei122 – 1221CitrullineUniRule annotation
Binding sitei123 – 1231AspartateUniRule annotation
Binding sitei126 – 1261CitrullineUniRule annotation
Binding sitei174 – 1741CitrullineUniRule annotation
Binding sitei259 – 2591CitrullineUniRule annotation
Binding sitei271 – 2711CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciLRHA568704:GHIC-1433-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotationImported
Ordered Locus Names:LC705_02805Imported
OrganismiLactobacillus rhamnosus (strain Lc 705)Imported
Taxonomic identifieri568704 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000956: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi568704.LC705_02805.

Structurei

3D structure databases

ProteinModelPortaliC7TN60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7TN60-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEKIVLAYS GGLDTSVAIP WLMDKGYEVI AVVLNVGQPD ADFDAIQQKA
60 70 80 90 100
LKVGAIDSIV VDAQDEFADH YVAPVIKANA LYEGDYPLVS ALSRPLIIEH
110 120 130 140 150
LVKIAHAQNA TAIAHGSTGK GNDQVRFEAA IHALDPEMKI EAPIRDFHWS
160 170 180 190 200
REEEIDYAKE HHVPVPIGKK SPYSIDANLW GRANEAGILE NPWNQAPDDA
210 220 230 240 250
WGMTVAPEAA PDKPTFLDLT FQQGVPVALN GNPMPLAAMI KQLNQIAGAN
260 270 280 290 300
GIGRIDKIEN RLVGIKSREV YEAPAAAVLM TAHHDLENLT LERDVQHFKP
310 320 330 340 350
TIENKLTNMI YEAQWISPLF DALMAFIDKT QAVVNGTVKM KLYKGSAVPV
360 370 380 390 400
ARQSTHNSLY DEDLATYTSA DSFDQEAAAG FIKLWTLPTT VFEQVNHVHS

EEKQHD
Length:406
Mass (Da):44,672
Last modified:October 13, 2009 - v1
Checksum:i76D686C3FF317638
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM179323 Genomic DNA. Translation: CAR91644.1.
RefSeqiYP_003175495.1. NC_013199.1.

Genome annotation databases

EnsemblBacteriaiCAR91644; CAR91644; LC705_02805.
GeneIDi8432833.
KEGGilrl:LC705_02805.
PATRICi22272438. VBILacRha58455_2602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM179323 Genomic DNA. Translation: CAR91644.1 .
RefSeqi YP_003175495.1. NC_013199.1.

3D structure databases

ProteinModelPortali C7TN60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 568704.LC705_02805.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR91644 ; CAR91644 ; LC705_02805 .
GeneIDi 8432833.
KEGGi lrl:LC705_02805.
PATRICi 22272438. VBILacRha58455_2602.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci LRHA568704:GHIC-1433-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Lc 705Imported.

Entry informationi

Entry nameiC7TN60_LACRL
AccessioniPrimary (citable) accession number: C7TN60
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3