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C7TN60 (C7TN60_LACRL) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate synthase HAMAP-Rule MF_00005

EC=6.3.4.5 HAMAP-Rule MF_00005
Alternative name(s):
Citrulline--aspartate ligase HAMAP-Rule MF_00005
Gene names
Name:argG HAMAP-Rule MF_00005 EMBL CAR91644.1
Ordered Locus Names:LC705_02805 EMBL CAR91644.1
OrganismLactobacillus rhamnosus (strain Lc 705) [Complete proteome] [HAMAP] EMBL CAR91644.1
Taxonomic identifier568704 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP-Rule MF_00005 SAAS SAAS023434

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP-Rule MF_00005 SAAS SAAS023434

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00005 SAAS SAAS023434

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00005 SAAS SAAS023434.

Sequence similarities

Belongs to the argininosuccinate synthase family. Type 1 subfamily. HAMAP-Rule MF_00005

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding8 – 169ATP By similarity HAMAP-Rule MF_00005

Sites

Binding site861Citrulline By similarity HAMAP-Rule MF_00005
Binding site1161ATP; via amide nitrogen By similarity HAMAP-Rule MF_00005
Binding site1181Aspartate By similarity HAMAP-Rule MF_00005
Binding site1221Aspartate By similarity HAMAP-Rule MF_00005
Binding site1221Citrulline By similarity HAMAP-Rule MF_00005
Binding site1231Aspartate By similarity HAMAP-Rule MF_00005
Binding site1261Citrulline By similarity HAMAP-Rule MF_00005
Binding site1741Citrulline By similarity HAMAP-Rule MF_00005
Binding site2591Citrulline By similarity HAMAP-Rule MF_00005
Binding site2711Citrulline By similarity HAMAP-Rule MF_00005

Sequences

Sequence LengthMass (Da)Tools
C7TN60 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 76D686C3FF317638

FASTA40644,672
        10         20         30         40         50         60 
MTEKIVLAYS GGLDTSVAIP WLMDKGYEVI AVVLNVGQPD ADFDAIQQKA LKVGAIDSIV 

        70         80         90        100        110        120 
VDAQDEFADH YVAPVIKANA LYEGDYPLVS ALSRPLIIEH LVKIAHAQNA TAIAHGSTGK 

       130        140        150        160        170        180 
GNDQVRFEAA IHALDPEMKI EAPIRDFHWS REEEIDYAKE HHVPVPIGKK SPYSIDANLW 

       190        200        210        220        230        240 
GRANEAGILE NPWNQAPDDA WGMTVAPEAA PDKPTFLDLT FQQGVPVALN GNPMPLAAMI 

       250        260        270        280        290        300 
KQLNQIAGAN GIGRIDKIEN RLVGIKSREV YEAPAAAVLM TAHHDLENLT LERDVQHFKP 

       310        320        330        340        350        360 
TIENKLTNMI YEAQWISPLF DALMAFIDKT QAVVNGTVKM KLYKGSAVPV ARQSTHNSLY 

       370        380        390        400 
DEDLATYTSA DSFDQEAAAG FIKLWTLPTT VFEQVNHVHS EEKQHD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FM179323 Genomic DNA. Translation: CAR91644.1.
RefSeqYP_003175495.1. NC_013199.1.

3D structure databases

ProteinModelPortalC7TN60.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING568704.LC705_02805.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR91644; CAR91644; LC705_02805.
GeneID8432833.
KEGGlrl:LC705_02805.
PATRIC22272438. VBILacRha58455_2602.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230093.
KOK01940.
OMAIYNGYWW.
OrthoDBEOG6K9QCV.
ProtClustDBPRK00509.

Enzyme and pathway databases

BioCycLRHA568704:GHIC-1433-MONOMER.
UniPathwayUPA00068; UER00113.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7TN60_LACRL
AccessionPrimary (citable) accession number: C7TN60
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)