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C7TGY0 (C7TGY0_LACRL) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Galactokinase HAMAP-Rule MF_00246
EC=2.7.1.6 HAMAP-Rule MF_00246
Alternative name(s):
Galactose kinase HAMAP-Rule MF_00246
Gene names
Name:galK HAMAP-Rule MF_00246 EMBL CAR89464.1
Ordered Locus Names:LC705_00625 EMBL CAR89464.1
OrganismLactobacillus rhamnosus (strain Lc 705) [Complete proteome] [HAMAP] EMBL CAR89464.1
Taxonomic identifier568704 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus ›

Protein attributes

Sequence length388 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) By similarity. HAMAP-Rule MF_00246 SAAS SAAS006206

Catalytic activity

ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate. HAMAP-Rule MF_00246

Pathway

Carbohydrate metabolism; galactose metabolism. HAMAP-Rule MF_00246 SAAS SAAS006206

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00246 SAAS SAAS006206.

Sequence similarities

Belongs to the GHMP kinase family. GalK subfamily. HAMAP-Rule MF_00246

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding124 – 1307ATP By similarity HAMAP-Rule MF_00246
Region33 – 364Substrate binding By similarity HAMAP-Rule MF_00246

Sites

Active site1741Proton acceptor By similarity HAMAP-Rule MF_00246
Metal binding1301Magnesium By similarity HAMAP-Rule MF_00246
Metal binding1621Magnesium By similarity HAMAP-Rule MF_00246
Binding site671ATP By similarity HAMAP-Rule MF_00246
Binding site2241Substrate By similarity HAMAP-Rule MF_00246
Site271Transition state stabilizer By similarity HAMAP-Rule MF_00246

Sequences

Sequence LengthMass (Da)Tools
C7TGY0 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 6B5B2C3F015301CB

FASTA38842,396
        10         20         30         40         50         60 
MNSTDVTKGF TEQFGKQAEH TFFAPGRINL IGEHTDYNGG HVFPCAISLG TYAAVGANDD 

        70         80         90        100        110        120 
NAFRLYSANF PKVGIIDIPF PDLFQDKRGL WTDYFQGMAR VMKTAGINYT HGLNVYINGN 

       130        140        150        160        170        180 
LPDGAGLSSS ASLEMLVGTI LNNLFDGGFA PLDLVKFGVK VENDYIGVNS GIMDQFAIEM 

       190        200        210        220        230        240 
GRANQATLLD TNTMKYEYLP VEMGDNVIVI MNTNKRRELT DSKYNERRSE CEKALAMLQK 

       250        260        270        280        290        300 
GIDVKSLGQL TEDEFDENTY LIYDETLIKR ARHAVFENQR TLTAAKALQS GDLKTFGKLV 

       310        320        330        340        350        360 
SASGVSLAFD YEVTGIELDT LVTNALKQRG VLGARMTGAG FGGCAIAIVN SADVEDFISN 

       370        380 
VGKAYTEKIG YDAHFYVADI ADGAKQLN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FM179323 Genomic DNA. Translation: CAR89464.1.
RefSeqYP_003173315.1. NC_013199.1.

3D structure databases

ProteinModelPortalC7TGY0.
SMRC7TGY0. Positions 5-387.
ModBaseSearch...

Protein-protein interaction databases

STRING568704.LC705_00625.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR89464; CAR89464; LC705_00625.
GeneID8433317.
KEGGlrl:LC705_00625.
PATRIC22268267. VBILacRha58455_0588.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0153.
HOGENOMHOG000241101.
KOK00849.
OMAIEMGRAN.
ProtClustDBCLSK2317747.

Enzyme and pathway databases

BioCycLRHA568704:GHIC-1747-MONOMER.
UniPathwayUPA00214.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00246. Galactokinase.
InterProIPR000705. Galactokinase.
IPR022963. Galactokinase_bac.
IPR019741. Galactokinase_CS.
IPR019539. GalKase_gal-bd.
IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF10509. GalKase_gal_bdg. 1 hit.
PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000530. Galactokinase. 1 hit.
PRINTSPR00473. GALCTOKINASE.
PR00959. MEVGALKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00131. gal_kin. 1 hit.
PROSITEPS00106. GALACTOKINASE. 1 hit.
PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7TGY0_LACRL
AccessionPrimary (citable) accession number: C7TGY0
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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