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Protein
Submitted name:

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Lactobacillus rhamnosus (strain ATCC 53103 / GG)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91Tele-phosphohistidine intermediateUniRule annotation
Binding sitei15 – 1512-phospho-D-glycerateUniRule annotation
Binding sitei60 – 6012-phospho-D-glycerateUniRule annotation
Binding sitei98 – 9812-phospho-D-glycerateUniRule annotation
Active sitei182 – 1821UniRule annotation
Binding sitei184 – 18412-phospho-D-glycerateUniRule annotation

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLRHA568703:GCGS-2110-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Submitted name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseImported
Submitted name:
Phosphoglycerate mutaseImported
Gene namesi
Name:gpmAUniRule annotationImported
Ordered Locus Names:LGG_02138Imported, LRHM_2055Imported
OrganismiLactobacillus rhamnosus (strain ATCC 53103 / GG)Imported
Taxonomic identifieri568703 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000955 Componenti: Chromosome UP000002067 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi568703.LGG_02138.

Structurei

3D structure databases

ProteinModelPortaliC7TEJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 2222-phospho-D-glycerate bindingUniRule annotation
Regioni87 – 9042-phospho-D-glycerate bindingUniRule annotation
Regioni114 – 11522-phospho-D-glycerate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0588.
HOGENOMiHOG000221682.
KOiK01834.
OMAiDRVLPYW.
OrthoDBiEOG6C8N1H.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7TEJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLVLIRHG QSEWNLSNQF TGWVDVDLSE KGVEEAKHAG ELIKQAGLEF
60 70 80 90 100
DQAYTSVLTR AIKTLHYVLE ESGQLWIPEM KTWRLNERHY GALQGLNKKE
110 120 130 140 150
TADKYGADQV HIWRRSYDVL PPLLKATDEG SAAKDRRYAD LDPRIIPGGE
160 170 180 190 200
NLKVTLERVI PFWEDHIAPD LLDGKNVVIA AHGNSLRALT KYIENISDAD
210 220
IMNLEMATGE PVVYDFDEKL NVNSKTKLD
Length:229
Mass (Da):25,954
Last modified:October 13, 2009 - v1
Checksum:i3E36188BACE898CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011548 Genomic DNA. Translation: BAI42582.1.
FM179322 Genomic DNA. Translation: CAR88033.1.
RefSeqiYP_003171884.1. NC_013198.1.
YP_005866547.1. NC_017482.1.

Genome annotation databases

EnsemblBacteriaiBAI42582; BAI42582; LRHM_2055.
CAR88033; CAR88033; LGG_02138.
KEGGilrg:LRHM_2055.
lrh:LGG_02138.
PATRICi22265526. VBILacRha2892_2031.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011548 Genomic DNA. Translation: BAI42582.1.
FM179322 Genomic DNA. Translation: CAR88033.1.
RefSeqiYP_003171884.1. NC_013198.1.
YP_005866547.1. NC_017482.1.

3D structure databases

ProteinModelPortaliC7TEJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi568703.LGG_02138.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI42582; BAI42582; LRHM_2055.
CAR88033; CAR88033; LGG_02138.
KEGGilrg:LRHM_2055.
lrh:LGG_02138.
PATRICi22265526. VBILacRha2892_2031.

Phylogenomic databases

eggNOGiCOG0588.
HOGENOMiHOG000221682.
KOiK01834.
OMAiDRVLPYW.
OrthoDBiEOG6C8N1H.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.
BioCyciLRHA568703:GCGS-2110-MONOMER.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of the probiotic Lactobacillus rhamnosus ATCC 53103."
    Morita H., Toh H., Oshima K., Murakami M., Taylor T.D., Igimi S., Hattori M.
    J. Bacteriol. 191:7630-7631(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 53103Imported and ATCC 53103 / GG [Tokyo]Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 53103 / GG [Helsinki]Imported.
  3. "Genomic Adaptation of the Lactobacillus casei Group."
    Toh H., Oshima K., Nakano A., Takahata M., Murakami M., Takaki T., Nishiyama H., Igimi S., Hattori M., Morita H.
    PLoS ONE 8:e75073-e75073(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 53103Imported.

Entry informationi

Entry nameiC7TEJ0_LACRG
AccessioniPrimary (citable) accession number: C7TEJ0
Secondary accession number(s): C8UW28
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: April 1, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.