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Protein
Submitted name:

RNA methyltransferase

Gene

LRHM_1605

Organism
Lactobacillus rhamnosus (strain ATCC 53103 / GG)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.SAAS annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(967) in 16S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(967) in 16S rRNA.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei284S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei312S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei331S-adenosyl-L-methioninePROSITE-ProRule annotation1
Active sitei384NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotationImported, RNA-bindingPROSITE-ProRule annotationSAAS annotation, Transferase
Biological processrRNA processingSAAS annotation
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
RNA methyltransferaseImported
Gene namesi
Ordered Locus Names:LRHM_1605Imported
OrganismiLactobacillus rhamnosus (strain ATCC 53103 / GG)Imported
Taxonomic identifieri568703 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000002067 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi568703.LGG_01669.

Structurei

3D structure databases

ProteinModelPortaliC7TD71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 445SAM_MT_RSMB_NOPInterPro annotationAdd BLAST277

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CYJ. Bacteria.
COG0144. LUCA.
HOGENOMiHOG000037300.
KOiK03500.
OMAiHIGLYQL.

Family and domain databases

Gene3Di1.10.940.10. 1 hit.
3.40.50.150. 1 hit.
InterProiView protein in InterPro
IPR018314. Fmu/NOL1/Nop2p_CS.
IPR031341. Methyltr_RsmF_N.
IPR001678. MeTrfase_RsmB/NOP2.
IPR006027. NusB_RsmB_TIM44.
IPR023267. RCMT.
IPR004573. rRNA_ssu_MeTfrase_B.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01189. Methyltr_RsmB-F. 1 hit.
PF17125. Methyltr_RsmF_N. 1 hit.
PF01029. NusB. 1 hit.
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF48013. SSF48013. 1 hit.
SSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00563. rsmB. 1 hit.
PROSITEiView protein in PROSITE
PS01153. NOL1_NOP2_SUN. 1 hit.
PS51686. SAM_MT_RSMB_NOP. 1 hit.

Sequencei

Sequence statusi: Complete.

C7TD71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPNNPRLLA VQTLTRVMGK GGYSNLTLDH VITKYQLDSR DAGLLTNVVY
60 70 80 90 100
GVIQHQLTLD YLLAPFVKNR QLDTWVRCLL QTAVYQLQYL DKVPARAVFF
110 120 130 140 150
DSTEIAKKLG HQGVAKFVTG VLRQAQRSGY PDPMTIADPI QRLAITSSTP
160 170 180 190 200
VWLVKKLQAQ LGETKTAKIL AAINQPAHAS IRVNTTKTTA AALLKALQPQ
210 220 230 240 250
FPALKESPLT PVGLVAPGGH LAGTREFADG LYTMQDESSM LVAPSLDVQP
260 270 280 290 300
GDQVLDACAA PGGKTTHIAQ YLDPDQGGRV TALDLHANKV RLIQQNAKRL
310 320 330 340 350
DLDDRVAAQV MDARQVAANF AAESFDKILV DAPCSGLGLI RRKPEIKYTK
360 370 380 390 400
QPEDLQHLQK IQLAILDSVA PTLKIGGRLT YSTCTMVKEE NQDVVAHFLA
410 420 430 440
THPEFEQVPV LTLKPLAKTH GAPALQLFPD DYDTDGFFIA SLIRRK
Length:446
Mass (Da):48,818
Last modified:October 13, 2009 - v1
Checksum:i40EF49E3A4AB0538
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011548 Genomic DNA. Translation: BAI42132.1.
RefSeqiWP_014569712.1. NC_017482.1.

Genome annotation databases

EnsemblBacteriaiBAI42132; BAI42132; LRHM_1605.
GeneIDi8422699.
KEGGilrg:LRHM_1605.
lrh:LGG_01669.
PATRICi22264588. VBILacRha2892_1574.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011548 Genomic DNA. Translation: BAI42132.1.
RefSeqiWP_014569712.1. NC_017482.1.

3D structure databases

ProteinModelPortaliC7TD71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi568703.LGG_01669.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI42132; BAI42132; LRHM_1605.
GeneIDi8422699.
KEGGilrg:LRHM_1605.
lrh:LGG_01669.
PATRICi22264588. VBILacRha2892_1574.

Phylogenomic databases

eggNOGiENOG4105CYJ. Bacteria.
COG0144. LUCA.
HOGENOMiHOG000037300.
KOiK03500.
OMAiHIGLYQL.

Family and domain databases

Gene3Di1.10.940.10. 1 hit.
3.40.50.150. 1 hit.
InterProiView protein in InterPro
IPR018314. Fmu/NOL1/Nop2p_CS.
IPR031341. Methyltr_RsmF_N.
IPR001678. MeTrfase_RsmB/NOP2.
IPR006027. NusB_RsmB_TIM44.
IPR023267. RCMT.
IPR004573. rRNA_ssu_MeTfrase_B.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF01189. Methyltr_RsmB-F. 1 hit.
PF17125. Methyltr_RsmF_N. 1 hit.
PF01029. NusB. 1 hit.
PRINTSiPR02008. RCMTFAMILY.
SUPFAMiSSF48013. SSF48013. 1 hit.
SSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00563. rsmB. 1 hit.
PROSITEiView protein in PROSITE
PS01153. NOL1_NOP2_SUN. 1 hit.
PS51686. SAM_MT_RSMB_NOP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC7TD71_LACRG
AccessioniPrimary (citable) accession number: C7TD71
Secondary accession number(s): C8UUS8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 15, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.