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Protein

Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Gene

LRHM_1268

Organism
Lactobacillus rhamnosus (strain ATCC 53103 / GG)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Cofactori

(R)-lipoateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciLRHA568703:GCGS-1311-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Ordered Locus Names:LRHM_1268Imported
OrganismiLactobacillus rhamnosus (strain ATCC 53103 / GG)Imported
Taxonomic identifieri568703 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000002067 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi568703.LGG_01322.

Structurei

3D structure databases

ProteinModelPortaliC7TC74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 7776Lipoyl-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C7S. Bacteria.
COG0508. LUCA.
HOGENOMiHOG000281564.
KOiK00627.
OMAiQKMFLSH.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7TC74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFEFKLPEL GEGLAEGEIV KWDVKPGDDI KEDDTLLEVQ SDKSVEEIPS
60 70 80 90 100
PVSGKILKIL VPEGETATVG EALVDIDAPG HNDTPVASGT AAAPQANTDT
110 120 130 140 150
AAPAAAPAAA GSVPAITDPN REILAMPSVR QYAREQGIDI SQVPATGKHG
160 170 180 190 200
RITKADIDAF KAGAPAAAPA QPAATSAPKA AQPAPAATPA APKPQPVAPY
210 220 230 240 250
VSTGSEAELE TREKMTPTRK AIAKAMLASK QRSPHVTSFD EVEVSKLMAH
260 270 280 290 300
RKKYKQYAAD KGIKLTFLPY IVKALVTVLR EYPEFNASID DTTDEIVYKH
310 320 330 340 350
YFNIGIATNT DHGLYVPVIK NADAKSMFEI AKEISDNAQK AYDSKLKPDE
360 370 380 390 400
MRGGSMTISN VGSIGGGWFT PVINQPEVAI LGVGKIAKEP YVNADNEIVV
410 420 430 440
GNLLKLSLSY DHRLIDGALA QTALNLMDKL LADPDLLLME G
Length:441
Mass (Da):46,808
Last modified:October 13, 2009 - v1
Checksum:iF2F39FD03472A93A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011548 Genomic DNA. Translation: BAI41795.1.
RefSeqiWP_014569608.1. NC_017482.1.

Genome annotation databases

EnsemblBacteriaiBAI41795; BAI41795; LRHM_1268.
GeneIDi8422631.
KEGGilrg:LRHM_1268.
lrh:LGG_01322.
PATRICi22263920. VBILacRha2892_1241.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011548 Genomic DNA. Translation: BAI41795.1.
RefSeqiWP_014569608.1. NC_017482.1.

3D structure databases

ProteinModelPortaliC7TC74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi568703.LGG_01322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI41795; BAI41795; LRHM_1268.
GeneIDi8422631.
KEGGilrg:LRHM_1268.
lrh:LGG_01322.
PATRICi22263920. VBILacRha2892_1241.

Phylogenomic databases

eggNOGiENOG4105C7S. Bacteria.
COG0508. LUCA.
HOGENOMiHOG000281564.
KOiK00627.
OMAiQKMFLSH.

Enzyme and pathway databases

BioCyciLRHA568703:GCGS-1311-MONOMER.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC7TC74_LACRG
AccessioniPrimary (citable) accession number: C7TC74
Secondary accession number(s): C8UTU1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 7, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.