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C7TBS1

- C7TBS1_LACRG

UniProt

C7TBS1 - C7TBS1_LACRG

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Protein
Thymidine kinase
Gene
tdk, LGG_01169, LRHM_1116
Organism
Lactobacillus rhamnosus (strain ATCC 53103 / GG)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptor By similarityUniRule annotation
Metal bindingi143 – 1431Zinc By similarityUniRule annotation
Metal bindingi146 – 1461Zinc By similarityUniRule annotation
Metal bindingi180 – 1801Zinc By similarityUniRule annotation
Metal bindingi183 – 1831Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi85 – 884ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciLRHA568703:GCGS-1159-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:LGG_01169Imported, LRHM_1116Imported
OrganismiLactobacillus rhamnosus (strain ATCC 53103 / GG)
Taxonomic identifieri568703 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000955: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi568703.LGG_01169.

Structurei

3D structure databases

ProteinModelPortaliC7TBS1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076391.
KOiK00857.
OMAiELKTVCH.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7TBS1-1 [UniParc]FASTAAdd to Basket

« Hide

MAQLFFRYGA MNSGKSIEIL KVAHNYEEQN KRVILMTSAV DDRAGVGMIA    50
SRIGLERTAI PIAHETNLYD VIKTTDPKAA CVLIDEAQFL QKHHIFEAAR 100
VVDELHIPVM AFGLKNDFRN ELFEGSKYLL LYADKIEEMK TICWFCAKKA 150
IMNLRIHDGK PVYEGEQVLI GGNESYYPVC RHHYFHPPLD RIDQDEE 197
Length:197
Mass (Da):22,617
Last modified:October 13, 2009 - v1
Checksum:i3F6C5FEE5C8910BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011548 Genomic DNA. Translation: BAI41643.1.
FM179322 Genomic DNA. Translation: CAR87064.1.
RefSeqiYP_003170915.1. NC_013198.1.
YP_005865608.1. NC_017482.1.

Genome annotation databases

EnsemblBacteriaiBAI41643; BAI41643; LRHM_1116.
CAR87064; CAR87064; LGG_01169.
GeneIDi12474234.
8422509.
KEGGilrg:LRHM_1116.
lrh:LGG_01169.
PATRICi22263625. VBILacRha2892_1094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011548 Genomic DNA. Translation: BAI41643.1 .
FM179322 Genomic DNA. Translation: CAR87064.1 .
RefSeqi YP_003170915.1. NC_013198.1.
YP_005865608.1. NC_017482.1.

3D structure databases

ProteinModelPortali C7TBS1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 568703.LGG_01169.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAI41643 ; BAI41643 ; LRHM_1116 .
CAR87064 ; CAR87064 ; LGG_01169 .
GeneIDi 12474234.
8422509.
KEGGi lrg:LRHM_1116.
lrh:LGG_01169.
PATRICi 22263625. VBILacRha2892_1094.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076391.
KOi K00857.
OMAi ELKTVCH.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci LRHA568703:GCGS-1159-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of the probiotic Lactobacillus rhamnosus ATCC 53103."
    Morita H., Toh H., Oshima K., Murakami M., Taylor T.D., Igimi S., Hattori M.
    J. Bacteriol. 191:7630-7631(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 53103Imported and ATCC 53103 / GG [Tokyo].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 53103 / GG [Helsinki].
  3. "Genomic Adaptation of the Lactobacillus casei Group."
    Toh H., Oshima K., Nakano A., Takahata M., Murakami M., Takaki T., Nishiyama H., Igimi S., Hattori M., Morita H.
    PLoS ONE 8:e75073-e75073(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 53103Imported.

Entry informationi

Entry nameiC7TBS1_LACRG
AccessioniPrimary (citable) accession number: C7TBS1
Secondary accession number(s): C8UTD9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: June 11, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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