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C7T8V0

- C7T8V0_LACRG

UniProt

C7T8V0 - C7T8V0_LACRG

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Protein
D-alanine--D-alanine ligase
Gene
ddlA, ddl, LGG_00148, LRHM_0148
Organism
Lactobacillus rhamnosus (strain ATCC 53103 / GG)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi294 – 2941Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi306 – 3061Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi306 – 3061Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi308 – 3081Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi172 – 22554ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciLRHA568703:GCGS-148-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlAImported
Synonyms:ddlUniRule annotation
Ordered Locus Names:LGG_00148Imported, LRHM_0148Imported
OrganismiLactobacillus rhamnosus (strain ATCC 53103 / GG)
Taxonomic identifieri568703 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000000955: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Protein-protein interaction databases

STRINGi568703.LGG_00148.

Structurei

3D structure databases

ProteinModelPortaliC7T8V0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 339195ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000011592.
KOiK01921.
OMAiRSAYGIY.
OrthoDBiEOG6ND0KB.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7T8V0-1 [UniParc]FASTAAdd to Basket

« Hide

MKIVVLAGGR STERNVSISS GYRITNALRQ KGQQATFIDL FLGYDLEGKT    50
VDQVFDDANT SKDLKISDAI LTDADINKLR IDGSTQLFGP NVLAICKAAD 100
IVFLALHGGD GENGKVQATL DLNNVKYTGS GPLASGITMN KVFSKEVMLY 150
HGIQTAAFKE FKRNQNGKHT VPFDFPVVVK PTSGGSSVGT HIAHNQEELE 200
NGIADVFRFD NSAIVEEFTP GREFSLGVVN GRAFSAIEIK VHSGWYDFKH 250
KFQAGYTDFI TPPKNLDESV HQAMKDVSLQ TMDVLGLQNY GRIDFFANDK 300
GVWVIEANNL PGMTPLSLLP QEAEADGVEY GDLVMDIING KLKLYAEGMT 350
EAGIMTTANH 360
Length:360
Mass (Da):39,261
Last modified:October 13, 2009 - v1
Checksum:i36583BD6C82AADA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011548 Genomic DNA. Translation: BAI40675.1.
FM179322 Genomic DNA. Translation: CAR86043.1.
RefSeqiWP_014568966.1. NC_017482.1.
YP_003169894.1. NC_013198.1.
YP_005864640.1. NC_017482.1.

Genome annotation databases

EnsemblBacteriaiBAI40675; BAI40675; LRHM_0148.
CAR86043; CAR86043; LGG_00148.
GeneIDi12473223.
8420513.
KEGGilrg:LRHM_0148.
lrh:LGG_00148.
PATRICi22261628. VBILacRha2892_0141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP011548 Genomic DNA. Translation: BAI40675.1 .
FM179322 Genomic DNA. Translation: CAR86043.1 .
RefSeqi WP_014568966.1. NC_017482.1.
YP_003169894.1. NC_013198.1.
YP_005864640.1. NC_017482.1.

3D structure databases

ProteinModelPortali C7T8V0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 568703.LGG_00148.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAI40675 ; BAI40675 ; LRHM_0148 .
CAR86043 ; CAR86043 ; LGG_00148 .
GeneIDi 12473223.
8420513.
KEGGi lrg:LRHM_0148.
lrh:LGG_00148.
PATRICi 22261628. VBILacRha2892_0141.

Phylogenomic databases

eggNOGi COG1181.
HOGENOMi HOG000011592.
KOi K01921.
OMAi RSAYGIY.
OrthoDBi EOG6ND0KB.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci LRHA568703:GCGS-148-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of the probiotic Lactobacillus rhamnosus ATCC 53103."
    Morita H., Toh H., Oshima K., Murakami M., Taylor T.D., Igimi S., Hattori M.
    J. Bacteriol. 191:7630-7631(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 53103Imported and ATCC 53103 / GG [Tokyo].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 53103 / GG [Helsinki].
  3. "Genomic Adaptation of the Lactobacillus casei Group."
    Toh H., Oshima K., Nakano A., Takahata M., Murakami M., Takaki T., Nishiyama H., Igimi S., Hattori M., Morita H.
    PLoS ONE 8:e75073-e75073(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 53103Imported.

Entry informationi

Entry nameiC7T8V0_LACRG
AccessioniPrimary (citable) accession number: C7T8V0
Secondary accession number(s): C8UYQ5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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