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Protein

D-alanine--D-alanine ligase

Gene

LRHM_0148

Organism
Lactobacillus rhamnosus (strain ATCC 53103 / GG)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Mg2+SAAS annotation, Mn2+SAAS annotationNote: Binds 2 magnesium or manganese ions per subunit.SAAS annotation

Pathway: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciLRHA568703:GCGS-148-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:LRHM_0148Imported
OrganismiLactobacillus rhamnosus (strain ATCC 53103 / GG)Imported
Taxonomic identifieri568703 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000002067 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi568703.LGG_00148.

Structurei

3D structure databases

ProteinModelPortaliC7T8V0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000011592.
KOiK01921.
OMAiARYNPGR.
OrthoDBiEOG6ND0KB.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7T8V0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIVVLAGGR STERNVSISS GYRITNALRQ KGQQATFIDL FLGYDLEGKT
60 70 80 90 100
VDQVFDDANT SKDLKISDAI LTDADINKLR IDGSTQLFGP NVLAICKAAD
110 120 130 140 150
IVFLALHGGD GENGKVQATL DLNNVKYTGS GPLASGITMN KVFSKEVMLY
160 170 180 190 200
HGIQTAAFKE FKRNQNGKHT VPFDFPVVVK PTSGGSSVGT HIAHNQEELE
210 220 230 240 250
NGIADVFRFD NSAIVEEFTP GREFSLGVVN GRAFSAIEIK VHSGWYDFKH
260 270 280 290 300
KFQAGYTDFI TPPKNLDESV HQAMKDVSLQ TMDVLGLQNY GRIDFFANDK
310 320 330 340 350
GVWVIEANNL PGMTPLSLLP QEAEADGVEY GDLVMDIING KLKLYAEGMT
360
EAGIMTTANH
Length:360
Mass (Da):39,261
Last modified:October 13, 2009 - v1
Checksum:i36583BD6C82AADA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011548 Genomic DNA. Translation: BAI40675.1.
RefSeqiWP_014568966.1. NC_017482.1.
YP_003169894.1. NC_013198.1.
YP_005864640.1. NC_017482.1.

Genome annotation databases

EnsemblBacteriaiBAI40675; BAI40675; LRHM_0148.
CAR86043; CAR86043; LGG_00148.
GeneIDi8420513.
KEGGilrg:LRHM_0148.
lrh:LGG_00148.
PATRICi22261628. VBILacRha2892_0141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011548 Genomic DNA. Translation: BAI40675.1.
RefSeqiWP_014568966.1. NC_017482.1.
YP_003169894.1. NC_013198.1.
YP_005864640.1. NC_017482.1.

3D structure databases

ProteinModelPortaliC7T8V0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi568703.LGG_00148.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAI40675; BAI40675; LRHM_0148.
CAR86043; CAR86043; LGG_00148.
GeneIDi8420513.
KEGGilrg:LRHM_0148.
lrh:LGG_00148.
PATRICi22261628. VBILacRha2892_0141.

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000011592.
KOiK01921.
OMAiARYNPGR.
OrthoDBiEOG6ND0KB.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciLRHA568703:GCGS-148-MONOMER.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the probiotic Lactobacillus rhamnosus ATCC 53103."
    Morita H., Toh H., Oshima K., Murakami M., Taylor T.D., Igimi S., Hattori M.
    J. Bacteriol. 191:7630-7631(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 53103 / GG [Tokyo]Imported.

Entry informationi

Entry nameiC7T8V0_LACRG
AccessioniPrimary (citable) accession number: C7T8V0
Secondary accession number(s): C8UYQ5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: June 24, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.