C7T794 (C7T794_LACRG) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alanine racemase RuleBase RU000608
EC=5.1.1.1 RuleBase RU000608

Gene names

Name:	alr EMBL CAR88431.1
Ordered Locus Names:	LGG_02536, LRHM_2433 EMBL BAI42960.1

Organism

Lactobacillus rhamnosus (strain ATCC 53103 / GG) [Complete proteome] [HAMAP]

Taxonomic identifier

568703 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus rhamnosus

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-alanine = D-alanine. SAAS SAAS020622
Cofactor	Pyridoxal phosphate By similarity. SAAS SAAS020622
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. SAAS SAAS020622
Sequence similarities	Belongs to the alanine racemase family. RuleBase RU004188

Ontologies

Keywords
Ligand	Pyridoxal phosphate SAAS SAAS020622
Molecular function	Isomerase SAAS SAAS020622
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	D-alanine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C7T794 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: F3DB8FE136716B0B	FASTA	379	41,267
	10 20 30 40 50 60 MTIGNLRPAT VLIDETAILH NVQHEVARLK KQTQLFAVVK ADAYGHGMLR VAHVAKAAGA 70 80 90 100 110 120 SGFCVALLDE ALDLRAANYT EPVLVLGIVP SQYAAIAAAQ TVSLPLSSVD WLKQALPVLE 130 140 150 160 170 180 AQPELPPLRL HIALDTGMGR IGFTDDQTLL DAVAFIQAHP KAFTIEGIFT HFATADDPDD 190 200 210 220 230 240 AYFKQQVAKF NHMVALLPHR PRYVHVSNSA TSLWHAACNG NMVRYGVAIY GLNPSGDVIP 250 260 270 280 290 300 TTPFPLEPAL SLESELTFCK QVHAGDGISY GVTYRATGDE FIGTVPVGYA DGWLRRLQGF 310 320 330 340 350 360 HVLVDGHLCE IVGRICMDQF MIRLPKAYPA GTKVVLIGQS GDQEITLLDV AKYSHTIHYE 370 IACNLTSRLK RQSINPIAR

References

[1]

"Complete genome sequence of the probiotic Lactobacillus rhamnosus ATCC 53103." Morita H., Toh H., Oshima K., Murakami M., Taylor T.D., Igimi S., Hattori M. J. Bacteriol. 191:7630-7631(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 53103 EMBL BAI42960.1 and ATCC 53103 / GG [Tokyo].

[2]

"Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein." Kankainen M., Paulin L., Tynkkynen S., von Ossowski I., Reunanen J., Partanen P., Satokari R., Vesterlund S., Hendrickx A.P.A., Lebeer S., De Keersmaecker S.C.J., Vanderleyden J., Hamalinen T., Laukkanen S., Salovuori N., Ritari J., Alatalo E., Korpela R. , Mattila-Sandholm T., Lassig A., Hatakka K., Kinnunen K.T., Karjalainen H., Saxelin M., Laakso K., Surakka A., Palva A., SalusjArvi T., Auvinen P., de Vos W.M. Proc. Natl. Acad. Sci. U.S.A. 106:17193-17198(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 53103 / GG [Helsinki].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP011548 Genomic DNA. Translation: BAI42960.1. FM179322 Genomic DNA. Translation: CAR88431.1.
RefSeq	YP_003172282.1. NC_013198.1. YP_005866925.1. NC_017482.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	568703.LGG_02536.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAI42960; BAI42960; LRHM_2433. CAR88431; CAR88431; LGG_02536.
GeneID	12475585. 8421609.
KEGG	lrg:LRHM_2433. lrh:LGG_02536.
PATRIC	22266296. VBILacRha2892_2404.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0787.
HOGENOM	HOG000031444.
KO	K01775.
OMA	IRLPKAY.
ProtClustDB	CLSK842788.
Enzyme and pathway databases
UniPathway	UPA00042; UER00497.
Family and domain databases
Gene3D	2.40.37.10. 1 hit.
HAMAP	MF_01201. Ala_racemase.
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C7T794_LACRG

Accession

Primary (citable) accession number: C7T794
Secondary accession number(s): C8UX56

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)