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C7T794

- C7T794_LACRG

UniProt

C7T794 - C7T794_LACRG

Protein

Alanine racemase

Gene

alr

Organism
Lactobacillus rhamnosus (strain ATCC 53103 / GG)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei140 – 1401SubstrateUniRule annotation
    Active sitei270 – 2701Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei317 – 3171Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciLRHA568703:GCGS-2502-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:LGG_02536Imported, LRHM_2433Imported
    OrganismiLactobacillus rhamnosus (strain ATCC 53103 / GG)Imported
    Taxonomic identifieri568703 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000002067: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi568703.LGG_02536.

    Structurei

    3D structure databases

    ProteinModelPortaliC7T794.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiYGHGLER.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C7T794-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTIGNLRPAT VLIDETAILH NVQHEVARLK KQTQLFAVVK ADAYGHGMLR    50
    VAHVAKAAGA SGFCVALLDE ALDLRAANYT EPVLVLGIVP SQYAAIAAAQ 100
    TVSLPLSSVD WLKQALPVLE AQPELPPLRL HIALDTGMGR IGFTDDQTLL 150
    DAVAFIQAHP KAFTIEGIFT HFATADDPDD AYFKQQVAKF NHMVALLPHR 200
    PRYVHVSNSA TSLWHAACNG NMVRYGVAIY GLNPSGDVIP TTPFPLEPAL 250
    SLESELTFCK QVHAGDGISY GVTYRATGDE FIGTVPVGYA DGWLRRLQGF 300
    HVLVDGHLCE IVGRICMDQF MIRLPKAYPA GTKVVLIGQS GDQEITLLDV 350
    AKYSHTIHYE IACNLTSRLK RQSINPIAR 379
    Length:379
    Mass (Da):41,267
    Last modified:October 13, 2009 - v1
    Checksum:iF3DB8FE136716B0B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011548 Genomic DNA. Translation: BAI42960.1.
    FM179322 Genomic DNA. Translation: CAR88431.1.
    RefSeqiYP_003172282.1. NC_013198.1.
    YP_005866925.1. NC_017482.1.

    Genome annotation databases

    EnsemblBacteriaiBAI42960; BAI42960; LRHM_2433.
    CAR88431; CAR88431; LGG_02536.
    GeneIDi12475585.
    8421609.
    KEGGilrg:LRHM_2433.
    lrh:LGG_02536.
    PATRICi22266296. VBILacRha2892_2404.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP011548 Genomic DNA. Translation: BAI42960.1 .
    FM179322 Genomic DNA. Translation: CAR88431.1 .
    RefSeqi YP_003172282.1. NC_013198.1.
    YP_005866925.1. NC_017482.1.

    3D structure databases

    ProteinModelPortali C7T794.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 568703.LGG_02536.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAI42960 ; BAI42960 ; LRHM_2433 .
    CAR88431 ; CAR88431 ; LGG_02536 .
    GeneIDi 12475585.
    8421609.
    KEGGi lrg:LRHM_2433.
    lrh:LGG_02536.
    PATRICi 22266296. VBILacRha2892_2404.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi YGHGLER.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci LRHA568703:GCGS-2502-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the probiotic Lactobacillus rhamnosus ATCC 53103."
      Morita H., Toh H., Oshima K., Murakami M., Taylor T.D., Igimi S., Hattori M.
      J. Bacteriol. 191:7630-7631(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 53103Imported and ATCC 53103 / GG [Tokyo]Imported.
    2. "Genomic Adaptation of the Lactobacillus casei Group."
      Toh H., Oshima K., Nakano A., Takahata M., Murakami M., Takaki T., Nishiyama H., Igimi S., Hattori M., Morita H.
      PLoS ONE 8:e75073-e75073(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC 53103Imported.

    Entry informationi

    Entry nameiC7T794_LACRG
    AccessioniPrimary (citable) accession number: C7T794
    Secondary accession number(s): C8UX56
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3