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Protein

Conotoxin Eb6.14

Gene

E1

Organism
Conus ebraeus (Hebrew cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Miscellaneous

This precursor corresponds to allele E1bii. Has not been merged with other alleles since they may differ due to geographic variation (see strain in PubMed:19606224).

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Eb6.14
Gene namesi
Name:E1
OrganismiConus ebraeus (Hebrew cone)
Taxonomic identifieri89425 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri3836. Eb6.14 precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 17Sequence analysisAdd BLAST›17
PropeptideiPRO_000041463818 – 41By similarityAdd BLAST24
PeptideiPRO_000041463942 – 69Conotoxin Eb6.14Add BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 57By similarity
Disulfide bondi50 ↔ 61By similarity
Disulfide bondi56 ↔ 68By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiC7T1P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin O1 superfamily.Curated

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR004214. Conotoxin.
PfamiView protein in Pfam
PF02950. Conotoxin. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

C7T1P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLIIAVLFLT ACQLTTAETY SRGRQKHRAR RSTDRNSKWT RECTDSGGAC
60
NSHDQCCNEF CSTATRTCI
Length:69
Mass (Da):7,745
Last modified:October 13, 2009 - v1
Checksum:iAEA947F3BF10C4E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ834437 Genomic DNA. Translation: ACU56816.1.

Similar proteinsi

Entry informationi

Entry nameiC614B_CONEA
AccessioniPrimary (citable) accession number: C7T1P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: October 13, 2009
Last modified: November 22, 2017
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families