ID   C7S316_HUMAN            Unreviewed;       129 AA.
AC   C7S316;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   27-MAR-2024, entry version 107.
DE   RecName: Full=Potassium voltage-gated channel subfamily E member 1 {ECO:0000256|ARBA:ARBA00035196};
GN   Name=KCNE1 {ECO:0000313|EMBL:ABS84249.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABS84249.1};
RN   [1] {ECO:0000313|EMBL:ABS84249.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19660109; DOI=10.1186/1471-2148-9-188;
RA   Herlyn H., Zechner U., Oswald F., Pfeufer A., Zischler H., Haaf T.;
RT   "Positive selection at codon 38 of the human KCNE1 (= minK) gene and
RT   sporadic absence of 38Ser-coding mRNAs in Gly38Ser heterozygotes.";
RL   BMC Evol. Biol. 9:188-188(2009).
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000256|ARBA:ARBA00004221}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251}. Membrane raft
CC       {ECO:0000256|ARBA:ARBA00004285}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the potassium channel KCNE family.
CC       {ECO:0000256|ARBA:ARBA00005688}.
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DR   EMBL; EF514881; ABS84249.1; -; Genomic_DNA.
DR   EMBL; EF514882; ABS84250.1; -; mRNA.
DR   RefSeq; NP_000210.2; NM_000219.5.
DR   RefSeq; NP_001121140.1; NM_001127668.3.
DR   RefSeq; NP_001121141.1; NM_001127669.3.
DR   RefSeq; NP_001121142.1; NM_001127670.3.
DR   RefSeq; NP_001257331.1; NM_001270402.2.
DR   RefSeq; NP_001257332.1; NM_001270403.2.
DR   RefSeq; NP_001257333.1; NM_001270404.2.
DR   RefSeq; NP_001257334.1; NM_001270405.2.
DR   AlphaFoldDB; C7S316; -.
DR   SMR; C7S316; -.
DR   Antibodypedia; 22953; 286 antibodies from 29 providers.
DR   DNASU; 3753; -.
DR   GeneID; 3753; -.
DR   KEGG; hsa:3753; -.
DR   CTD; 3753; -.
DR   PharmGKB; PA211; -.
DR   VEuPathDB; HostDB:ENSG00000180509; -.
DR   HOGENOM; CLU_159026_0_0_1; -.
DR   OMA; ESCRACY; -.
DR   BioGRID-ORCS; 3753; 12 hits in 1153 CRISPR screens.
DR   ChiTaRS; KCNE1; human.
DR   GenomeRNAi; 3753; -.
DR   ExpressionAtlas; C7S316; baseline and differential.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0005251; F:delayed rectifier potassium channel activity; IEA:Ensembl.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:Ensembl.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR   GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR   GO; GO:0071468; P:cellular response to acidic pH; IEA:Ensembl.
DR   GO; GO:0071482; P:cellular response to light stimulus; IEA:Ensembl.
DR   GO; GO:0002070; P:epithelial cell maturation; IEA:Ensembl.
DR   GO; GO:0060047; P:heart contraction; IEA:Ensembl.
DR   GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR   GO; GO:0090315; P:negative regulation of protein targeting to membrane; IEA:Ensembl.
DR   GO; GO:1901381; P:positive regulation of potassium ion transmembrane transport; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0033363; P:secretory granule organization; IEA:Ensembl.
DR   GO; GO:0021750; P:vestibular nucleus development; IEA:Ensembl.
DR   InterPro; IPR000369; K_chnl_KCNE.
DR   InterPro; IPR005424; KCNE1.
DR   PANTHER; PTHR15282; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1, 3; 1.
DR   PANTHER; PTHR15282:SF10; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY E MEMBER 1-RELATED; 1.
DR   Pfam; PF02060; ISK_Channel; 1.
DR   PRINTS; PR01604; KCNE1CHANNEL.
DR   PRINTS; PR00168; KCNECHANNEL.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        44..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   129 AA;  14675 MW;  5442D70929D4E87E CRC64;
     MILSNTTAVT PFLTKLWQET VQQGGNMSGL ARRSPRSSDG KLEALYVLMV LGFFGFFTLG
     IMLSYIRSKK LEHSNDPFNV YIESDAWQEK DKAYVQARVL ESYRSCYVVE NHLAIEQPNT
     HLPETKPSP
//