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Protein
Submitted name:

Potassium voltage-gated channel Isk-related family member 1

Gene

KCNE1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage-gated channel Isk-related family member 1Imported
Gene namesi
Name:KCNE1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6623HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA211.

PTM / Processingi

Proteomic databases

PaxDbiC7S316.
PRIDEiC7S316.

Expressioni

Gene expression databases

BgeeiC7S316.
ExpressionAtlasiC7S316. baseline and differential.
GenevisibleiC7S316. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000337255.

Chemistry

BindingDBiC7S316.

Structurei

3D structure databases

ProteinModelPortaliC7S316.
SMRiC7S316. Positions 1-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IY71. Eukaryota.
ENOG410Y1SF. LUCA.
KOiK04894.
OMAiALYILMV.
PhylomeDBiC7S316.

Family and domain databases

InterProiIPR000369. K_chnl_KCNE.
IPR005424. K_chnl_volt-dep_bsu_KCNE1.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR01604. KCNE1CHANNEL.
PR00168. KCNECHANNEL.

Sequencei

Sequence statusi: Complete.

C7S316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSNTTAVT PFLTKLWQET VQQGGNMSGL ARRSPRSSDG KLEALYVLMV
60 70 80 90 100
LGFFGFFTLG IMLSYIRSKK LEHSNDPFNV YIESDAWQEK DKAYVQARVL
110 120
ESYRSCYVVE NHLAIEQPNT HLPETKPSP
Length:129
Mass (Da):14,675
Last modified:October 13, 2009 - v1
Checksum:i5442D70929D4E87E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF514881 Genomic DNA. Translation: ABS84249.1.
EF514882 mRNA. Translation: ABS84250.1.
RefSeqiNP_000210.2. NM_000219.5.
NP_001121140.1. NM_001127668.3.
NP_001121141.1. NM_001127669.3.
NP_001121142.1. NM_001127670.3.
NP_001257331.1. NM_001270402.2.
NP_001257332.1. NM_001270403.2.
NP_001257333.1. NM_001270404.2.
NP_001257334.1. NM_001270405.2.
UniGeneiHs.121495.
Hs.745384.

Genome annotation databases

GeneIDi3753.
KEGGihsa:3753.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF514881 Genomic DNA. Translation: ABS84249.1.
EF514882 mRNA. Translation: ABS84250.1.
RefSeqiNP_000210.2. NM_000219.5.
NP_001121140.1. NM_001127668.3.
NP_001121141.1. NM_001127669.3.
NP_001121142.1. NM_001127670.3.
NP_001257331.1. NM_001270402.2.
NP_001257332.1. NM_001270403.2.
NP_001257333.1. NM_001270404.2.
NP_001257334.1. NM_001270405.2.
UniGeneiHs.121495.
Hs.745384.

3D structure databases

ProteinModelPortaliC7S316.
SMRiC7S316. Positions 1-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000337255.

Chemistry

BindingDBiC7S316.

Proteomic databases

PaxDbiC7S316.
PRIDEiC7S316.

Protocols and materials databases

DNASUi3753.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3753.
KEGGihsa:3753.

Organism-specific databases

CTDi3753.
PharmGKBiPA211.

Phylogenomic databases

eggNOGiENOG410IY71. Eukaryota.
ENOG410Y1SF. LUCA.
KOiK04894.
OMAiALYILMV.
PhylomeDBiC7S316.

Miscellaneous databases

ChiTaRSiKCNE1. human.
GenomeRNAii3753.
NextBioi14697.

Gene expression databases

BgeeiC7S316.
ExpressionAtlasiC7S316. baseline and differential.
GenevisibleiC7S316. HS.

Family and domain databases

InterProiIPR000369. K_chnl_KCNE.
IPR005424. K_chnl_volt-dep_bsu_KCNE1.
[Graphical view]
PfamiPF02060. ISK_Channel. 1 hit.
[Graphical view]
PRINTSiPR01604. KCNE1CHANNEL.
PR00168. KCNECHANNEL.
ProtoNetiSearch...

Publicationsi

  1. "Positive selection at codon 38 of the human KCNE1 (= minK) gene and sporadic absence of 38Ser-coding mRNAs in Gly38Ser heterozygotes."
    Herlyn H., Zechner U., Oswald F., Pfeufer A., Zischler H., Haaf T.
    BMC Evol. Biol. 9:188-188(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiC7S316_HUMAN
AccessioniPrimary (citable) accession number: C7S316
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: December 9, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.