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C7S316

- C7S316_HUMAN

UniProt

C7S316 - C7S316_HUMAN

Protein
Submitted name:

Potassium voltage-gated channel Isk-related family member 1

Gene

KCNE1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: Ensembl

    GO - Biological processi

    1. cellular response to acidic pH Source: Ensembl
    2. epithelial cell maturation Source: Ensembl
    3. heart contraction Source: Ensembl
    4. male gonad development Source: Ensembl
    5. negative regulation of protein targeting to membrane Source: Ensembl
    6. positive regulation of potassium ion transmembrane transport Source: Ensembl
    7. regulation of heart rate by cardiac conduction Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Potassium voltage-gated channel Isk-related family member 1Imported
    Gene namesi
    Name:KCNE1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. endoplasmic reticulum Source: Ensembl
    3. voltage-gated potassium channel complex Source: Ensembl
    4. Z disc Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA211.

    Structurei

    3D structure databases

    SMRiC7S316. Positions 1-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    KOiK04894.
    OMAiSYRACYV.
    PhylomeDBiC7S316.

    Family and domain databases

    InterProiIPR000369. K_chnl_volt-dep_bsu_KCNE.
    IPR005424. K_chnl_volt-dep_bsu_KCNE1.
    [Graphical view]
    PANTHERiPTHR17028. PTHR17028. 1 hit.
    PfamiPF02060. ISK_Channel. 1 hit.
    [Graphical view]
    PRINTSiPR01604. KCNE1CHANNEL.
    PR00168. KCNECHANNEL.

    Sequencei

    Sequence statusi: Complete.

    C7S316-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILSNTTAVT PFLTKLWQET VQQGGNMSGL ARRSPRSSDG KLEALYVLMV    50
    LGFFGFFTLG IMLSYIRSKK LEHSNDPFNV YIESDAWQEK DKAYVQARVL 100
    ESYRSCYVVE NHLAIEQPNT HLPETKPSP 129
    Length:129
    Mass (Da):14,675
    Last modified:October 13, 2009 - v1
    Checksum:i5442D70929D4E87E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF514881 Genomic DNA. Translation: ABS84249.1.
    EF514882 mRNA. Translation: ABS84250.1.
    RefSeqiNP_000210.2. NM_000219.5.
    NP_001121140.1. NM_001127668.3.
    NP_001121141.1. NM_001127669.3.
    NP_001121142.1. NM_001127670.3.
    NP_001257331.1. NM_001270402.2.
    NP_001257332.1. NM_001270403.2.
    NP_001257333.1. NM_001270404.2.
    NP_001257334.1. NM_001270405.2.
    UniGeneiHs.121495.
    Hs.745384.

    Genome annotation databases

    GeneIDi3753.
    KEGGihsa:3753.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF514881 Genomic DNA. Translation: ABS84249.1 .
    EF514882 mRNA. Translation: ABS84250.1 .
    RefSeqi NP_000210.2. NM_000219.5.
    NP_001121140.1. NM_001127668.3.
    NP_001121141.1. NM_001127669.3.
    NP_001121142.1. NM_001127670.3.
    NP_001257331.1. NM_001270402.2.
    NP_001257332.1. NM_001270403.2.
    NP_001257333.1. NM_001270404.2.
    NP_001257334.1. NM_001270405.2.
    UniGenei Hs.121495.
    Hs.745384.

    3D structure databases

    SMRi C7S316. Positions 1-129.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 3753.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3753.
    KEGGi hsa:3753.

    Organism-specific databases

    CTDi 3753.
    PharmGKBi PA211.

    Phylogenomic databases

    KOi K04894.
    OMAi SYRACYV.
    PhylomeDBi C7S316.

    Miscellaneous databases

    GenomeRNAii 3753.
    NextBioi 14697.

    Family and domain databases

    InterProi IPR000369. K_chnl_volt-dep_bsu_KCNE.
    IPR005424. K_chnl_volt-dep_bsu_KCNE1.
    [Graphical view ]
    PANTHERi PTHR17028. PTHR17028. 1 hit.
    Pfami PF02060. ISK_Channel. 1 hit.
    [Graphical view ]
    PRINTSi PR01604. KCNE1CHANNEL.
    PR00168. KCNECHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "Positive selection at codon 38 of the human KCNE1 (= minK) gene and sporadic absence of 38Ser-coding mRNAs in Gly38Ser heterozygotes."
      Herlyn H., Zechner U., Oswald F., Pfeufer A., Zischler H., Haaf T.
      BMC Evol. Biol. 9:188-188(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiC7S316_HUMAN
    AccessioniPrimary (citable) accession number: C7S316
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.