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C7S226

- C7S226_I57A0

UniProt

C7S226 - C7S226_I57A0

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Protein
Submitted name:

Hemagglutinin

Gene
HA
Organism
Influenza A virus (strain A/Japan/305/1957 H2N2)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore By similarity.UniRule annotationSAAS annotations

GO - Biological processi

  1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. fusion of virus membrane with host plasma membrane Source: InterPro
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HemagglutininUniRule annotationSAAS annotations

Keywords - Biological processi

Clathrin- and caveolin-independent endocytosis of virus by hostSAAS annotations, Clathrin-mediated endocytosis of virus by hostSAAS annotations, Fusion of virus membrane with host endosomal membraneSAAS annotations, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotations, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Submitted name:
HemagglutininImported
Gene namesi
Name:HAImported
OrganismiInfluenza A virus (strain A/Japan/305/1957 H2N2)Imported
Taxonomic identifieri387161 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostiAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotations, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotations, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 PredictedImportedAdd
BLAST
Chaini16 – 562547 PredictedImportedPRO_5000514962Add
BLAST
Chaini16 – 340325HA1ImportedPRO_5000514963Add
BLAST
Chaini341 – 562222HA2ImportedPRO_5000514964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...)Imported
Glycosylationi38 – 381N-linked (GlcNAc...)Imported
Glycosylationi179 – 1791N-linked (GlcNAc...)Imported
Glycosylationi300 – 3001N-linked (GlcNAc...)Imported
Glycosylationi494 – 4941N-linked (GlcNAc...)Imported

Keywords - PTMi

Disulfide bondSAAS annotations

Interactioni

Subunit structurei

Homotrimer of disulfide-linked HA1-HA2 By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KU3X-ray1.60A15-340[»]
B341-514[»]
3KU5X-ray1.73A15-340[»]
B341-514[»]
3KU6X-ray1.75A15-340[»]
B341-514[»]
3QQBX-ray1.97A15-340[»]
B341-514[»]
3QQEX-ray2.10A15-340[»]
B341-514[»]
3QQIX-ray1.65A/B61-279[»]
3QQOX-ray2.90A/C/E15-340[»]
B/D/F341-514[»]
4HF5X-ray3.00A15-340[»]
B341-514[»]
4HLZX-ray2.90A/C/E15-340[»]
B/D/F341-514[»]

Miscellaneous databases

EvolutionaryTraceiC7S226.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.10.77.10. 1 hit.
3.90.20.10. 1 hit.
3.90.209.20. 1 hit.
InterProiIPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view]
PfamiPF00509. Hemagglutinin. 1 hit.
[Graphical view]
PRINTSiPR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMiSSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C7S226-1 [UniParc]FASTAAdd to Basket

« Hide

MAIIYLILLF TAVRGDQICI GYHANNSTEK VDTILERNVT VTHAKDILEK    50
THNGKLCKLN GIPPLELGDC SIAGWLLGNP ECDRLLSVPE WSYIMEKENP 100
RDGLCYPGSF NDYEELKHLL SSVKHFEKVK ILPKDRWTQH TTTGGSRACA 150
VSGNPSFFRN MVWLTEKGSN YPVAKGSYNN TSGEQMLIIW GVHHPNDETE 200
QRTLYQNVGT YVSVGTSTLN KRSTPEIATR PKVNGQGGRM EFSWTLLDMW 250
DTINFESTGN LIAPEYGFKI SKRGSSGIMK TEGTLENCET KCQTPLGAIN 300
TTLPFHNVHP LTIGECPKYV KSEKLVLATG LRNVPQIESR GLFGAIAGFI 350
EGGWQGMVDG WYGYHHSNDQ GSGYAADKES TQKAFDGITN KVNSVIEKMN 400
TQFEAVGKEF SNLERRLENL NKKMEDGFLD VWTYNAELLV LMENERTLDF 450
HDSNVKNLYD KVRMQLRDNV KELGNGCFEF YHKCDDECMN SVKNGTYDYP 500
KYEEESKLNR NEIKGVKLSS MGVYQILAIY ATVAGSLSLA IMMAGISFWM 550
CSNGSLQCRI CI 562
Length:562
Mass (Da):63,120
Last modified:October 13, 2009 - v1
Checksum:iD4747A6A6733E733
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CY045804 Viral cRNA. Translation: ACV49600.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CY045804 Viral cRNA. Translation: ACV49600.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3KU3 X-ray 1.60 A 15-340 [» ]
B 341-514 [» ]
3KU5 X-ray 1.73 A 15-340 [» ]
B 341-514 [» ]
3KU6 X-ray 1.75 A 15-340 [» ]
B 341-514 [» ]
3QQB X-ray 1.97 A 15-340 [» ]
B 341-514 [» ]
3QQE X-ray 2.10 A 15-340 [» ]
B 341-514 [» ]
3QQI X-ray 1.65 A/B 61-279 [» ]
3QQO X-ray 2.90 A/C/E 15-340 [» ]
B/D/F 341-514 [» ]
4HF5 X-ray 3.00 A 15-340 [» ]
B 341-514 [» ]
4HLZ X-ray 2.90 A/C/E 15-340 [» ]
B/D/F 341-514 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei C7S226.

Family and domain databases

Gene3Di 2.10.77.10. 1 hit.
3.90.20.10. 1 hit.
3.90.209.20. 1 hit.
InterProi IPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view ]
Pfami PF00509. Hemagglutinin. 1 hit.
[Graphical view ]
PRINTSi PR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMi SSF49818. SSF49818. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The NIAID Influenza Genome Sequencing Project."
    Spiro D., Halpin R., Boyne A., Bera J., Ghedin E., Hostetler J., Fedorova N., Kim M., Zaborsky J., Overton L., Djuric K., Sarmiento M., Sitz J., Katzel D., Brown E.G., Keleta L., Bao Y., Sanders R.
    , Dernovoy D., Kiryutin B., Lipman D.J., Tatusova T.
    Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/Japan/305/1957Imported.
  2. The NIAID Influenza Genome Sequencing Consortium
    Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/Japan/305/1957Imported.
  3. "Structure, receptor binding, and antigenicity of influenza virus hemagglutinins from the 1957 H2N2 pandemic."
    Xu R., McBride R., Paulson J.C., Basler C.F., Wilson I.A.
    J. Virol. 84:1715-1721(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 15-340 AND 341-514, GLYCOSYLATION AT ASN-38; ASN-179 AND ASN-494.
  4. "Structural characterization of an early fusion intermediate of influenza virus hemagglutinin."
    Xu R., Wilson I.A.
    J. Virol. 85:5172-5182(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 61-279, GLYCOSYLATION AT ASN-26; ASN-38; ASN-179; ASN-300 AND ASN-494.
  5. "Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 influenza virus hemagglutinin."
    Dreyfus C., Ekiert D.C., Wilson I.A.
    J. Virol. 87:7149-7154(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 15-340 AND 341-514, GLYCOSYLATION AT ASN-26; ASN-179; ASN-300 AND ASN-494.
  6. "A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin."
    Xu R., Krause J.C., McBride R., Paulson J.C., Crowe J.E., Wilson I.A.
    Nat. Struct. Mol. Biol. 20:363-370(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 15-340 AND 341-514, GLYCOSYLATION AT ASN-179 AND ASN-300.

Entry informationi

Entry nameiC7S226_I57A0
AccessioniPrimary (citable) accession number: C7S226
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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