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C7RRS8 (C7RRS8_ACCPU) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-isopropylmalate dehydratase small subunit HAMAP-Rule MF_01031
EC=4.2.1.33 HAMAP-Rule MF_01031
Alternative name(s):
Alpha-IPM isomerase HAMAP-Rule MF_01031
Isopropylmalate isomerase HAMAP-Rule MF_01031
Gene names
Name:leuD HAMAP-Rule MF_01031
Ordered Locus Names:CAP2UW1_1239 EMBL ACV34567.1
OrganismAccumulibacter phosphatis (strain UW-1) [Complete proteome] [HAMAP] EMBL ACV34567.1
Taxonomic identifier522306 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Candidatus Accumulibacter ›

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate By similarity. HAMAP-Rule MF_01031

Catalytic activity

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. HAMAP-Rule MF_01031 SAAS SAAS004431

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4. HAMAP-Rule MF_01031 SAAS SAAS004431

Subunit structure

Heterodimer of LeuC and LeuD By similarity. HAMAP-Rule MF_01031 SAAS SAAS004431

Sequence similarities

Belongs to the LeuD family. LeuD type 1 subfamily. HAMAP-Rule MF_01031

Sequences

Sequence LengthMass (Da)Tools
C7RRS8 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 849973D6F7C82B9C

FASTA21323,765
        10         20         30         40         50         60 
MKPFTTLQGL VAPLDRANVD TDAIIPKQFL KSIKRSGFGP NAFDEWRYLD RGEPDRDCAT 

        70         80         90        100        110        120 
RPLNPDFVLN QPRYQGASIL LTRENFGCGS SREHAPWALE DYGFRAIIAP SFADIFFNNC 

       130        140        150        160        170        180 
FKNGILPIVL AATTVDRLFQ ETAAHAGYSL SLDLAAQTVT TPAGEVIPFV VDGECKHRLF 

       190        200        210 
NGLDDIGLTL LHTDKIKAYE ARRQAEAQWL FQT

« Hide

References

[1]"Complete sequence of chromosome of Candidatus Accumulibacter phosphatis clade IIA str. UW-1."
US DOE Joint Genome Institute
Martin H.G., Ivanova N., Kunin V., Warnecke F., Barry K., He S., Salamov A., Szeto E., Dalin E., Pangilinan J.L., Lapidus A., Lowry S., Kyrpides N.C., McMahon K.D., Hugenholtz P.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UW-1 EMBL ACV34567.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001715 Genomic DNA. Translation: ACV34567.1.
RefSeqYP_003166496.1. NC_013194.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING522306.CAP2UW1_1239.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV34567; ACV34567; CAP2UW1_1239.
GeneID8403376.
KEGGapp:CAP2UW1_1239.
PATRIC21258510. VBICanAcc132554_1516.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0066.
HOGENOMHOG000222939.
KOK01704.
ProtClustDBPRK01641.

Enzyme and pathway databases

BioCycAPHO522306:GHXL-1248-MONOMER.
UniPathwayUPA00048; UER00071.

Family and domain databases

Gene3D3.20.19.10. 1 hit.
HAMAPMF_01031. LeuD_type1.
InterProIPR004431. 3-IsopropMal_deHydase_ssu.
IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF2. PTHR11670:SF2. 1 hit.
PfamPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00171. leuD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7RRS8_ACCPU
AccessionPrimary (citable) accession number: C7RRS8
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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