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C7RRP8 (C7RRP8_ACCPU) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Threonine--tRNA ligase HAMAP-Rule MF_00184
EC=6.1.1.3 HAMAP-Rule MF_00184
Alternative name(s):
Threonyl-tRNA synthetase HAMAP-Rule MF_00184
Gene names
Name:thrS HAMAP-Rule MF_00184
Ordered Locus Names:CAP2UW1_1209 EMBL ACV34537.1
OrganismAccumulibacter phosphatis (strain UW-1) [Complete proteome] [HAMAP] EMBL ACV34537.1
Taxonomic identifier522306 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Candidatus Accumulibacter ›

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). HAMAP-Rule MF_00184 SAAS SAAS002320

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00184 SAAS SAAS002320

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00184

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00184.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. RuleBase RU003746 HAMAP-Rule MF_00184

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region242 – 533292Catalytic By similarity HAMAP-Rule MF_00184

Sites

Metal binding3331Zinc; catalytic By similarity HAMAP-Rule MF_00184
Metal binding3841Zinc; catalytic By similarity HAMAP-Rule MF_00184
Metal binding5101Zinc; catalytic By similarity HAMAP-Rule MF_00184

Sequences

Sequence LengthMass (Da)Tools
C7RRP8 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: B55E17D2B5FD3175

FASTA63872,145
        10         20         30         40         50         60 
MPIVTLPDGS QREFAQPVTV AEVAQSIGAG LARAALAGKI DGRLVDTSFR IDTDVHLGII 

        70         80         90        100        110        120 
TEKDPEGLEV IRHSTAHLMA YAVKELFPAA QVTIGPVIEN GFYYDFACER PFTLEDLAAI 

       130        140        150        160        170        180 
EKRMTELARR DLLVQREVWQ RDEAIAFFKS IGEHYKAELI DAIPPGQEVS LYREGDFVDL 

       190        200        210        220        230        240 
CRGPHVPSTG KLKVFKLMKL AGAYWRGDHR NEQLQRIYGT AWTRKEDQDA YLHLLEEAEK 

       250        260        270        280        290        300 
RDHRKLGRQL DLFHLQDEAP GMVFWHAKGW TIWQEVEQYM RRLLGENGYC EVKTPMIMDR 

       310        320        330        340        350        360 
TLWERSGHWQ NYAEHMFTTA SENRDYAIKP MNCPGHIQIF NQGLRSYRDL PLRLAEFGSC 

       370        380        390        400        410        420 
HRNEPSGALH GIMRVRAFVQ DDAHIFCTEA QVLPETAAFI DLLEKIYADF GFTDILVKLS 

       430        440        450        460        470        480 
TRPDKRIGSD AVWDRAEAAL AEALAAKGLA YDLQPGEGAF YGPKIEFSLK DCLGRVWQCG 

       490        500        510        520        530        540 
TLQLDFALPE RLDAHYVGED NDRHVPVMLH RAILGSLERF IGILIEHYAG AMPLWLSPMQ 

       550        560        570        580        590        600 
VVVLNISEKQ GDYAEQVAAT LRRAGLRAEA DLRNEKITRK IREHSLNKLP YQVVVGDKEV 

       610        620        630 
AANLVAVRTR GGQDLGQMSL ESLIRQLLEE VASRSGTA

« Hide

References

[1]"Complete sequence of chromosome of Candidatus Accumulibacter phosphatis clade IIA str. UW-1."
US DOE Joint Genome Institute
Martin H.G., Ivanova N., Kunin V., Warnecke F., Barry K., He S., Salamov A., Szeto E., Dalin E., Pangilinan J.L., Lapidus A., Lowry S., Kyrpides N.C., McMahon K.D., Hugenholtz P.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UW-1 EMBL ACV34537.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001715 Genomic DNA. Translation: ACV34537.1.
RefSeqYP_003166466.1. NC_013194.1.

3D structure databases

ProteinModelPortalC7RRP8.
ModBaseSearch...

Protein-protein interaction databases

STRING522306.CAP2UW1_1209.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV34537; ACV34537; CAP2UW1_1209.
GeneID8403345.
KEGGapp:CAP2UW1_1209.
PATRIC21258448. VBICanAcc132554_1486.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0441.
HOGENOMHOG000003878.
KOK01868.

Enzyme and pathway databases

BioCycAPHO522306:GHXL-1217-MONOMER.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPMF_00184. Thr_tRNA_synth.
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR012675. Beta-grasp_dom.
IPR004095. TGS.
IPR012676. TGS-like.
IPR002320. Thr-tRNA-ligase_IIa.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
IPR012947. tRNA_SAD.
[Graphical view]
PfamPF03129. HGTP_anticodon. 1 hit.
PF02824. TGS. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF07973. tRNA_SAD. 1 hit.
[Graphical view]
PRINTSPR01047. TRNASYNTHTHR.
SMARTSM00863. tRNA_SAD. 1 hit.
[Graphical view]
SUPFAMSSF52954. Anticodon_bd. 1 hit.
SSF81271. TGS-like. 1 hit.
SSF55186. Thr/Ala-tRNA-synth_IIc_edit. 1 hit.
TIGRFAMsTIGR00418. thrS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7RRP8_ACCPU
AccessionPrimary (citable) accession number: C7RRP8
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info