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C7RMJ3

- C7RMJ3_ACCPU

UniProt

C7RMJ3 - C7RMJ3_ACCPU

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Protein
Glutathione synthetase
Gene
gshB, CAP2UW1_0674
Organism
Accumulibacter phosphatis (strain UW-1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi281 – 2811Magnesium or manganese By similarityUniRule annotation
Metal bindingi283 – 2831Magnesium or manganese By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi151 – 20757ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutathione synthase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Glutathione biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAPHO522306:GHXL-680-MONOMER.
    UniPathwayiUPA00142; UER00210.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione synthetaseUniRule annotation (EC:6.3.2.3UniRule annotation)
    Alternative name(s):
    GSH synthetase
    Glutathione synthase
    Gene namesi
    Name:gshBUniRule annotation
    Ordered Locus Names:CAP2UW1_0674Imported
    OrganismiAccumulibacter phosphatis (strain UW-1)Imported
    Taxonomic identifieri522306 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaCandidatus Accumulibacter
    ProteomesiUP000001619: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: InterPro
    Complete GO annotation...

    Interactioni

    Protein-protein interaction databases

    STRINGi522306.CAP2UW1_0674.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini125 – 310186ATP-grasp By similarityUniRule annotation
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the prokaryotic GSH synthase family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0189.
    HOGENOMiHOG000265022.
    KOiK01920.
    OrthoDBiEOG6WMHWB.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPiMF_00162. GSH_S.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006284. Glut_synth_pro.
    IPR004218. GSHS_ATP-bd.
    IPR004215. GSHS_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PfamiPF02955. GSH-S_ATP. 1 hit.
    PF02951. GSH-S_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01380. glut_syn. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C7RMJ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIAFVVDPL GSLRAYKDSS VAMMRAAQAR GHAVWAVQQE AIHLSPLHGV    50
    CAEAVHLEML ADDHDWFVEI DRHVVALRDF GAVVMRKDPP FDIEYVTTTW 100
    LLERAEGEGA RVFNRPRALR DHSEKLSVAE FARFAVPTLV AREAALIHAF 150
    IDLERDTILK PLDGMGGSQI FRVRDDDANR NVIVETLTRD GARTIMAQRY 200
    IPEIVDGDKR ILLVGGQVVP WCLARIPKAG ETRGNLAAGG TGVARELTAR 250
    DHEIASALAP VLAARGLLLV GLDVIGDWLT EINVTSPTCM VEIAEQTGFD 300
    AAEMFVAALE RACAVAAV 318
    Length:318
    Mass (Da):34,747
    Last modified:October 13, 2009 - v1
    Checksum:iC2A0E9B613190CB2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001715 Genomic DNA. Translation: ACV34020.1.
    RefSeqiWP_015765268.1. NC_013194.1.
    YP_003165949.1. NC_013194.1.

    Genome annotation databases

    EnsemblBacteriaiACV34020; ACV34020; CAP2UW1_0674.
    GeneIDi8402806.
    KEGGiapp:CAP2UW1_0674.
    PATRICi21257356. VBICanAcc132554_0944.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001715 Genomic DNA. Translation: ACV34020.1 .
    RefSeqi WP_015765268.1. NC_013194.1.
    YP_003165949.1. NC_013194.1.

    3D structure databases

    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 522306.CAP2UW1_0674.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACV34020 ; ACV34020 ; CAP2UW1_0674 .
    GeneIDi 8402806.
    KEGGi app:CAP2UW1_0674.
    PATRICi 21257356. VBICanAcc132554_0944.

    Phylogenomic databases

    eggNOGi COG0189.
    HOGENOMi HOG000265022.
    KOi K01920.
    OrthoDBi EOG6WMHWB.

    Enzyme and pathway databases

    UniPathwayi UPA00142 ; UER00210 .
    BioCyci APHO522306:GHXL-680-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPi MF_00162. GSH_S.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006284. Glut_synth_pro.
    IPR004218. GSHS_ATP-bd.
    IPR004215. GSHS_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    Pfami PF02955. GSH-S_ATP. 1 hit.
    PF02951. GSH-S_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01380. glut_syn. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Candidatus Accumulibacter phosphatis clade IIA str. UW-1."
      US DOE Joint Genome Institute
      Martin H.G., Ivanova N., Kunin V., Warnecke F., Barry K., He S., Salamov A., Szeto E., Dalin E., Pangilinan J.L., Lapidus A., Lowry S., Kyrpides N.C., McMahon K.D., Hugenholtz P.
      Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UW-1Imported.

    Entry informationi

    Entry nameiC7RMJ3_ACCPU
    AccessioniPrimary (citable) accession number: C7RMJ3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: September 3, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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