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C7RKS6 (C7RKS6_ACCPU) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribosomal RNA large subunit methyltransferase E HAMAP-Rule MF_01547
EC=2.1.1.166 HAMAP-Rule MF_01547
Alternative name(s):
23S rRNA Um2552 methyltransferase HAMAP-Rule MF_01547
rRNA (uridine-2'-O-)-methyltransferase HAMAP-Rule MF_01547
Gene names
Name:rlmE HAMAP-Rule MF_01547
Synonyms:ftsJ HAMAP-Rule MF_01547, rrmJ HAMAP-Rule MF_01547
Ordered Locus Names:CAP2UW1_3746 EMBL ACV36996.1
OrganismAccumulibacter phosphatis (strain UW-1) [Complete proteome] [HAMAP] EMBL ACV36996.1
Taxonomic identifier522306 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Candidatus Accumulibacter ›

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit By similarity. HAMAP-Rule MF_01547

Catalytic activity

S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine(2552) in 23S rRNA. HAMAP-Rule MF_01547

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01547.

Sequence similarities

Belongs to the methyltransferase superfamily. RlmE family. HAMAP-Rule MF_01547

Ontologies

Keywords
   Biological processrRNA processing HAMAP-Rule MF_01547
   Cellular componentCytoplasm HAMAP-Rule MF_01547
   LigandS-adenosyl-L-methionine HAMAP-Rule MF_01547
   Molecular functionMethyltransferase HAMAP-Rule MF_01547 EMBL ACV36996.1
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionrRNA (uridine-2'-O-)-methyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1611Proton acceptor By similarity HAMAP-Rule MF_01547
Binding site601S-adenosyl-L-methionine; via amide nitrogen By similarity HAMAP-Rule MF_01547
Binding site621S-adenosyl-L-methionine; via amide nitrogen By similarity HAMAP-Rule MF_01547
Binding site801S-adenosyl-L-methionine By similarity HAMAP-Rule MF_01547
Binding site961S-adenosyl-L-methionine By similarity HAMAP-Rule MF_01547
Binding site1211S-adenosyl-L-methionine By similarity HAMAP-Rule MF_01547

Sequences

Sequence LengthMass (Da)Tools
C7RKS6 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 1248F505A1EA059D

FASTA20622,704
        10         20         30         40         50         60 
MNRSASSNRW LREHVSDAYV QRARAEGYRS RAAYKLMAID DTDHLLRSGD VIVDLGASPG 

        70         80         90        100        110        120 
GWSQVAARRL QGGGRVIAVD LLEMEPLRDV TFLQGDFREP DVIGRLETIL AGKKVGLVLS 

       130        140        150        160        170        180 
DMSPNISGIA VCDQARGMHL AELGLEFACK WLKPEGAFLV KVFQGHGFDD FLAAMRKAFK 

       190        200 
SVASRKPDAS RDRSPEIYLL GKTLKT

« Hide

References

[1]"Complete sequence of chromosome of Candidatus Accumulibacter phosphatis clade IIA str. UW-1."
US DOE Joint Genome Institute
Martin H.G., Ivanova N., Kunin V., Warnecke F., Barry K., He S., Salamov A., Szeto E., Dalin E., Pangilinan J.L., Lapidus A., Lowry S., Kyrpides N.C., McMahon K.D., Hugenholtz P.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UW-1 EMBL ACV36996.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001715 Genomic DNA. Translation: ACV36996.1.
RefSeqYP_003168925.1. NC_013194.1.

3D structure databases

ProteinModelPortalC7RKS6.
ModBaseSearch...

Protein-protein interaction databases

STRING522306.CAP2UW1_3746.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV36996; ACV36996; CAP2UW1_3746.
GeneID8405915.
KEGGapp:CAP2UW1_3746.
PATRIC21263780. VBICanAcc132554_4118.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0293.
HOGENOMHOG000162367.
KOK02427.
ProtClustDBCLSK2525771.

Enzyme and pathway databases

BioCycAPHO522306:GHXL-3780-MONOMER.

Family and domain databases

HAMAPMF_01547. 23SrRNA_methyltr_E.
InterProIPR015507. rRNA-MeTfrase_E.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
[Graphical view]
PANTHERPTHR10920. PTHR10920. 1 hit.
PfamPF01728. FtsJ. 1 hit.
[Graphical view]
PIRSFPIRSF005461. 23S_rRNA_mtase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7RKS6_ACCPU
AccessionPrimary (citable) accession number: C7RKS6
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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