UniProtKB - C7RHW4 (C7RHW4_ANAPD)
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Protein
Thymidine kinase
Gene
tdk
Organism
Anaerococcus prevotii (strain ATCC 9321 / DSM 20548 / JCM 6508 / PC1) (Peptostreptococcus prevotii) (Peptococcus prevotii)
Status
Functioni
Catalytic activityi
ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 87 | Proton acceptorUniRule annotation | 1 | |
Metal bindingi | 146 | ZincUniRule annotation | 1 | |
Metal bindingi | 149 | ZincUniRule annotation | 1 | |
Metal bindingi | 178 | ZincUniRule annotation | 1 | |
Metal bindingi | 181 | ZincUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 19 | ATPUniRule annotation | 8 | |
Nucleotide bindingi | 86 – 89 | ATPUniRule annotation | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- thymidine kinase activity Source: UniProtKB-UniRule
- zinc ion binding Source: UniProtKB-UniRule
GO - Biological processi
- DNA biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | KinaseUniRule annotationImported, Transferase |
Biological process | DNA synthesisUniRule annotation |
Ligand | ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:tdkUniRule annotation Ordered Locus Names:Apre_1047Imported |
Organismi | Anaerococcus prevotii (strain ATCC 9321 / DSM 20548 / JCM 6508 / PC1) (Peptostreptococcus prevotii) (Peptococcus prevotii)Imported |
Taxonomic identifieri | 525919 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Tissierellia › Tissierellales › Peptoniphilaceae › Anaerococcus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationInteractioni
Subunit structurei
Homotetramer.UniRule annotation
Protein-protein interaction databases
STRINGi | 525919.Apre_1047 |
Family & Domainsi
Sequence similaritiesi
Belongs to the thymidine kinase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4107104 Bacteria COG1435 LUCA |
HOGENOMi | HOG000076390 |
KOi | K00857 |
OMAi | CAGLDQD |
OrthoDBi | POG091H0659 |
Family and domain databases
HAMAPi | MF_00124 Thymidine_kinase, 1 hit |
InterProi | View protein in InterPro IPR027417 P-loop_NTPase IPR001267 Thymidine_kinase IPR020633 Thymidine_kinase_CS |
PANTHERi | PTHR11441 PTHR11441, 1 hit |
Pfami | View protein in Pfam PF00265 TK, 1 hit |
PIRSFi | PIRSF035805 TK_cell, 1 hit |
SUPFAMi | SSF52540 SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00603 TK_CELLULAR_TYPE, 1 hit |
i Sequence
Sequence statusi: Complete.
C7RHW4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKKQGRLIVH TGSMFSGKTT SLWRELYRMR IANYKIVAFK PSIDSRDDER
60 70 80 90 100
KIVSHDNLEL DAHKVENLRE ILAYAKNKDI DCIGIDELQF FPNDPGEVID
110 120 130 140 150
IFNELMAMKI TIVVSGLDMD YKTQPFEIIK EIMPIADELV KHHAICASCG
160 170 180 190 200
EDAWASYRKT SDESRIQIGS KDLYEPLCRS CYNKKMKEKE KYKNQISLED
I
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001708 Genomic DNA Translation: ACV29075.1 |
RefSeqi | WP_015777978.1, NC_013171.1 |
Genome annotation databases
EnsemblBacteriai | ACV29075; ACV29075; Apre_1047 |
KEGGi | apr:Apre_1047 |
Similar proteinsi
Entry informationi
Entry namei | C7RHW4_ANAPD | |
Accessioni | C7RHW4Primary (citable) accession number: C7RHW4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 13, 2009 |
Last sequence update: | October 13, 2009 | |
Last modified: | March 28, 2018 | |
This is version 59 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |