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Protein

Thymidine kinase

Gene

tdk

Organism
Anaerococcus prevotii (strain ATCC 9321 / DSM 20548 / JCM 6508 / PC1) (Peptostreptococcus prevotii) (Peptococcus prevotii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87Proton acceptorUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi149ZincUniRule annotation1
Metal bindingi178ZincUniRule annotation1
Metal bindingi181ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19ATPUniRule annotation8
Nucleotide bindingi86 – 89ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Apre_1047Imported
OrganismiAnaerococcus prevotii (strain ATCC 9321 / DSM 20548 / JCM 6508 / PC1) (Peptostreptococcus prevotii) (Peptococcus prevotii)Imported
Taxonomic identifieri525919 [NCBI]
Taxonomic lineageiBacteriaFirmicutesTissierelliaTissierellalesPeptoniphilaceaeAnaerococcus
Proteomesi
  • UP000002294 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi525919.Apre_1047

Structurei

3D structure databases

ProteinModelPortaliC7RHW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
HOGENOMiHOG000076390
KOiK00857
OMAiCAGLDQD
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

C7RHW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKQGRLIVH TGSMFSGKTT SLWRELYRMR IANYKIVAFK PSIDSRDDER
60 70 80 90 100
KIVSHDNLEL DAHKVENLRE ILAYAKNKDI DCIGIDELQF FPNDPGEVID
110 120 130 140 150
IFNELMAMKI TIVVSGLDMD YKTQPFEIIK EIMPIADELV KHHAICASCG
160 170 180 190 200
EDAWASYRKT SDESRIQIGS KDLYEPLCRS CYNKKMKEKE KYKNQISLED

I
Length:201
Mass (Da):23,302
Last modified:October 13, 2009 - v1
Checksum:i4B12D4D8941F510E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001708 Genomic DNA Translation: ACV29075.1
RefSeqiWP_015777978.1, NC_013171.1

Genome annotation databases

EnsemblBacteriaiACV29075; ACV29075; Apre_1047
KEGGiapr:Apre_1047

Similar proteinsi

Entry informationi

Entry nameiC7RHW4_ANAPD
AccessioniPrimary (citable) accession number: C7RHW4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: March 28, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported