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C7RHW4

- C7RHW4_ANAPD

UniProt

C7RHW4 - C7RHW4_ANAPD

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Protein

Thymidine kinase

Gene

tdk

Organism
Anaerococcus prevotii (strain ATCC 9321 / DSM 20548 / JCM 6508 / PC1) (Peptostreptococcus prevotii) (Peptococcus prevotii)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Proton acceptorUniRule annotation
Metal bindingi146 – 1461ZincUniRule annotation
Metal bindingi149 – 1491ZincUniRule annotation
Metal bindingi178 – 1781ZincUniRule annotation
Metal bindingi181 – 1811ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198ATPUniRule annotation
Nucleotide bindingi86 – 894ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAPRE525919:GI6D-1087-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Apre_1047Imported
OrganismiAnaerococcus prevotii (strain ATCC 9321 / DSM 20548 / JCM 6508 / PC1) (Peptostreptococcus prevotii) (Peptococcus prevotii)Imported
Taxonomic identifieri525919 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiales Family XI. Incertae SedisAnaerococcus
ProteomesiUP000002294: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi525919.Apre_1047.

Structurei

3D structure databases

ProteinModelPortaliC7RHW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiQAICLSC.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7RHW4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKQGRLIVH TGSMFSGKTT SLWRELYRMR IANYKIVAFK PSIDSRDDER
60 70 80 90 100
KIVSHDNLEL DAHKVENLRE ILAYAKNKDI DCIGIDELQF FPNDPGEVID
110 120 130 140 150
IFNELMAMKI TIVVSGLDMD YKTQPFEIIK EIMPIADELV KHHAICASCG
160 170 180 190 200
EDAWASYRKT SDESRIQIGS KDLYEPLCRS CYNKKMKEKE KYKNQISLED

I
Length:201
Mass (Da):23,302
Last modified:October 13, 2009 - v1
Checksum:i4B12D4D8941F510E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001708 Genomic DNA. Translation: ACV29075.1.
RefSeqiWP_015777978.1. NC_013171.1.
YP_003152796.1. NC_013171.1.

Genome annotation databases

EnsemblBacteriaiACV29075; ACV29075; Apre_1047.
GeneIDi8397834.
KEGGiapr:Apre_1047.
PATRICi20905360. VBIAnaPre102398_1159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001708 Genomic DNA. Translation: ACV29075.1 .
RefSeqi WP_015777978.1. NC_013171.1.
YP_003152796.1. NC_013171.1.

3D structure databases

ProteinModelPortali C7RHW4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 525919.Apre_1047.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACV29075 ; ACV29075 ; Apre_1047 .
GeneIDi 8397834.
KEGGi apr:Apre_1047.
PATRICi 20905360. VBIAnaPre102398_1159.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi QAICLSC.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci APRE525919:GI6D-1087-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 9321 / DSM 20548 / JCM 6508 / PC1Imported.

Entry informationi

Entry nameiC7RHW4_ANAPD
AccessioniPrimary (citable) accession number: C7RHW4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3