C7RHW4 (C7RHW4_ANAPD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thymidine kinase HAMAP-Rule MF_00124 RuleBase RU000544
EC=2.7.1.21 HAMAP-Rule MF_00124 RuleBase RU000544

Gene names

Name:	tdk HAMAP-Rule MF_00124
Ordered Locus Names:	Apre_1047 EMBL ACV29075.1

Organism

Anaerococcus prevotii (strain ATCC 9321 / DSM 20548 / JCM 6508 / PC1) (Peptostreptococcus prevotii) (Peptococcus prevotii) [Complete proteome] [HAMAP] EMBL ACV29075.1

Taxonomic identifier

525919 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiales incertae sedis › Clostridiales Family XI. Incertae Sedis › Anaerococcus › Anaerococcus prevotii

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124 RuleBase RU000544 SAAS SAAS020634
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_00124 SAAS SAAS020633
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00124 SAAS SAAS020633.
Sequence similarities	Belongs to the thymidine kinase family. HAMAP-Rule MF_00124

Ontologies

Keywords
Biological process	DNA synthesis HAMAP-Rule MF_00124 RuleBase RU000544 SAAS SAAS020634
Cellular component	Cytoplasm HAMAP-Rule MF_00124 SAAS SAAS020633
Ligand	ATP-binding HAMAP-Rule MF_00124 RuleBase RU000544 SAAS SAAS020634 Metal-binding HAMAP-Rule MF_00124 SAAS SAAS020633 Nucleotide-binding Zinc HAMAP-Rule MF_00124 SAAS SAAS020633
Molecular function	Kinase HAMAP-Rule MF_00124 RuleBase RU000544 SAAS SAAS020634 EMBL ACV29075.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-HAMAP thymidine kinase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	12 – 19	8	ATP By similarity HAMAP-Rule MF_00124
	Nucleotide binding	86 – 89	4	ATP By similarity HAMAP-Rule MF_00124
Sites
	Active site	87	1	Proton acceptor By similarity HAMAP-Rule MF_00124
	Metal binding	146	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	149	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	178	1	Zinc By similarity HAMAP-Rule MF_00124
	Metal binding	181	1	Zinc By similarity HAMAP-Rule MF_00124

Sequences

	Sequence		Length	Mass (Da)
	C7RHW4 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: 4B12D4D8941F510E	FASTA	201	23,302
	10 20 30 40 50 60 MKKQGRLIVH TGSMFSGKTT SLWRELYRMR IANYKIVAFK PSIDSRDDER KIVSHDNLEL 70 80 90 100 110 120 DAHKVENLRE ILAYAKNKDI DCIGIDELQF FPNDPGEVID IFNELMAMKI TIVVSGLDMD 130 140 150 160 170 180 YKTQPFEIIK EIMPIADELV KHHAICASCG EDAWASYRKT SDESRIQIGS KDLYEPLCRS 190 200 CYNKKMKEKE KYKNQISLED I

References

[1]

"Complete genome sequence of Anaerococcus prevotii type strain (PC1)." Labutti K., Pukall R., Steenblock K., Glavina Del Rio T., Tice H., Copeland A., Cheng J.-F., Lucas S., Chen F., Nolan M., Bruce D., Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G., Pati A., Chen A. , Palaniappan K., Land M., Hauser L., Chang Y.-J., Jeffries C.D., Chain P., Saunders E., Brettin T., Detter J.C., Han C., Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.-P., Lapidus A. Stand. Genomic Sci. 1:159-165(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 9321 / DSM 20548 / JCM 6508 / PC1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001708 Genomic DNA. Translation: ACV29075.1.
RefSeq	YP_003152796.1. NC_013171.1.
3D structure databases
ProteinModelPortal	C7RHW4.
ModBase	Search...
Protein-protein interaction databases
STRING	525919.Apre_1047.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACV29075; ACV29075; Apre_1047.
GeneID	8397834.
KEGG	apr:Apre_1047.
PATRIC	20905360. VBIAnaPre102398_1159.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1435.
HOGENOM	HOG000076390.
KO	K00857.
OMA	KVHAICV.
OrthoDB	EOG69D3J2.
ProtClustDB	CLSK2542021.
Enzyme and pathway databases
BioCyc	APRE525919:GI6D-1087-MONOMER.
Family and domain databases
HAMAP	MF_00124. Thymidine_kinase.
InterPro	IPR027417. P-loop_NTPase. IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. IPR020634. Thymidine_kinase_subgr. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C7RHW4_ANAPD

Accession

Primary (citable) accession number: C7RHW4

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	November 13, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)