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C7RHH4 (C7RHH4_ANAPD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GUN anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) By similarity. HAMAP-Rule MF_00168 RuleBase RU003777 SAAS SAAS004803

Catalytic activity

Guanine34 in tRNA + 7-aminomethyl-7-carbaguanine = 7-aminomethyl-7-carbaguanine34 in tRNA + guanine. HAMAP-Rule MF_00168 SAAS SAAS004803

Guanine34 in tRNA + queuine = queuosine34 in tRNA + guanine. HAMAP-Rule MF_00168 SAAS SAAS004803

[tRNA]-guanine + queuine = [tRNA]-queuine + guanine. RuleBase RU003777

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00168 RuleBase RU003777 SAAS SAAS004803

Pathway

tRNA modification; tRNA-queuosine biosynthesis. HAMAP-Rule MF_00168 SAAS SAAS004803

Sequence similarities

Belongs to the queuine tRNA-ribosyltransferase family. HAMAP-Rule MF_00168 RuleBase RU003777

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site931Nucleophile By similarity HAMAP-Rule MF_00168
Metal binding3071Zinc By similarity HAMAP-Rule MF_00168
Metal binding3091Zinc By similarity HAMAP-Rule MF_00168
Metal binding3121Zinc By similarity HAMAP-Rule MF_00168
Metal binding3381Zinc By similarity HAMAP-Rule MF_00168
Binding site941Substrate By similarity HAMAP-Rule MF_00168

Sequences

Sequence LengthMass (Da)Tools
C7RHH4 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: E3D16FB199F2A134

FASTA37242,554
        10         20         30         40         50         60 
MALKYELIKK DKYSNARVGV IHTAHGDIPT PIFMPVGTLG TVKTMTPEDL LGMGAKIILG 

        70         80         90        100        110        120 
NTYHLYLKPG MDIMKKAGGL HKFMNWDKPI LTDSGGFQVF SLSDNRKITE EGVTFRSHID 

       130        140        150        160        170        180 
GSKHLFTPEK SISIQNDIHS DIMMSFDECV DARADYDYVE NSMKRTLRWA KRGLDYHKEH 

       190        200        210        220        230        240 
SHPDQSLFGI VQGGMFKDLR ERSARETTAM DFDGFSIGGL SVGETKEEMI DILNFTTPFL 

       250        260        270        280        290        300 
PKDKPRYNMG VGTPDYLFES FEAGIDMADC VLPTRIARNG TALTSRGRLV VKNAAYKEDF 

       310        320        330        340        350        360 
TSLDHECDCY TCRNYSRAYI RHLMNVNEIL GARLLSYHNL YFLLKMCENI REAIMEDRFL 

       370 
DYKKEFYDKY GY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001708 Genomic DNA. Translation: ACV28935.1.
RefSeqYP_003152656.1. NC_013171.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING525919.Apre_0907.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV28935; ACV28935; Apre_0907.
GeneID8397693.
KEGGapr:Apre_0907.
PATRIC20905076. VBIAnaPre102398_1018.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0343.
HOGENOMHOG000223473.
KOK00773.
OMAMSPERSI.

Enzyme and pathway databases

BioCycAPRE525919:GI6D-946-MONOMER.
UniPathwayUPA00392.

Family and domain databases

Gene3D3.20.20.105. 1 hit.
HAMAPMF_00168. Q_tRNA_Tgt.
InterProIPR004803. Queuine_tRNA-ribosylTrfase.
IPR002616. tRNA_ribo_trans.
[Graphical view]
PANTHERPTHR11962. PTHR11962. 1 hit.
PfamPF01702. TGT. 1 hit.
[Graphical view]
SUPFAMSSF51713. tRNA_ribo_trans. 1 hit.
TIGRFAMsTIGR00430. Q_tRNA_tgt. 1 hit.
TIGR00449. tgt_general. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC7RHH4_ANAPD
AccessionPrimary (citable) accession number: C7RHH4
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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