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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Kangiella koreensis (strain DSM 16069 / KCTC 12182 / SW-125)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91SubstrateUniRule annotation
Binding sitei11 – 111SubstrateUniRule annotation
Active sitei95 – 951ElectrophileUniRule annotation
Active sitei167 – 1671Proton acceptorUniRule annotation

GO - Molecular functioni

  1. triose-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
  3. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

GluconeogenesisUniRule annotation, GlycolysisUniRule annotation, Pentose shuntUniRule annotation

Enzyme and pathway databases

BioCyciKKOR523791:GHCO-2403-MONOMER.
UniPathwayiUPA00109; UER00189.
UPA00109; UER00189.
UPA00138.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:Kkor_2353Imported
OrganismiKangiella koreensis (strain DSM 16069 / KCTC 12182 / SW-125)Imported
Taxonomic identifieri523791 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesAlcanivoracaceaeKangiella
ProteomesiUP000001231: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi523791.Kkor_2353.

Structurei

3D structure databases

ProteinModelPortaliC7R8J7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0149.
HOGENOMiHOG000226413.
KOiK01803.
OMAiEANRICG.
OrthoDBiEOG66QM23.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B.
InterProiIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7R8J7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTKLIAGNW KMHGSKPFIE SLMKGMTEQL DASLESDVLV CPPTIYIPFV
60 70 80 90 100
ESLIGDHKIA LGGQNLSEQA QGAYTGEVSG DMLKDNGCQY VIVGHSERRS
110 120 130 140 150
LYGEMDVLVA HKVGKAIESE LTPILCVGET LEQREKGTTM QVVQQQLDAV
160 170 180 190 200
IDALGIDALQ QVVVAYEPVW AIGTGVTASP EQAQEVHSAI RAHLRDKNAQ
210 220 230 240 250
IAEEIKILYG GSMKAANAEE LLAQPDIDGG LIGGASLKAD EFIAICKIAG
Length:250
Mass (Da):26,800
Last modified:October 13, 2009 - v1
Checksum:i1555A8E157C971AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001707 Genomic DNA. Translation: ACV27762.1.
RefSeqiWP_015781367.1. NC_013166.1.
YP_003147530.1. NC_013166.1.

Genome annotation databases

EnsemblBacteriaiACV27762; ACV27762; Kkor_2353.
GeneIDi8371171.
KEGGikko:Kkor_2353.
PATRICi22170144. VBIKanKor123990_2317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001707 Genomic DNA. Translation: ACV27762.1.
RefSeqiWP_015781367.1. NC_013166.1.
YP_003147530.1. NC_013166.1.

3D structure databases

ProteinModelPortaliC7R8J7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi523791.Kkor_2353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV27762; ACV27762; Kkor_2353.
GeneIDi8371171.
KEGGikko:Kkor_2353.
PATRICi22170144. VBIKanKor123990_2317.

Phylogenomic databases

eggNOGiCOG0149.
HOGENOMiHOG000226413.
KOiK01803.
OMAiEANRICG.
OrthoDBiEOG66QM23.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00109; UER00189.
UPA00138.
UPA00138.
BioCyciKKOR523791:GHCO-2403-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_B. TIM_B.
InterProiIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
TIGRFAMsiTIGR00419. tim. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16069 / KCTC 12182 / SW-125Imported.

Entry informationi

Entry nameiC7R8J7_KANKD
AccessioniPrimary (citable) accession number: C7R8J7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 4, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.