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C7R5E9

- C7R5E9_JONDD

UniProt

C7R5E9 - C7R5E9_JONDD

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Protein

Thymidine kinase

Gene

tdk

Organism
Jonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Proton acceptorUniRule annotation
Metal bindingi151 – 1511ZincUniRule annotation
Metal bindingi153 – 1531ZincUniRule annotation
Metal bindingi188 – 1881ZincUniRule annotation
Metal bindingi191 – 1911ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi93 – 964ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciJDEN471856:GH77-1623-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Jden_1574Imported
OrganismiJonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans)Imported
Taxonomic identifieri471856 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeJonesiaceaeJonesia
ProteomesiUP000000628: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi471856.Jden_1574.

Structurei

3D structure databases

ProteinModelPortaliC7R5E9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076391.
KOiK00857.
OMAiELKTVCH.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

C7R5E9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKLYFRYGA MNSGKSTALL QAAHNYEERG HQVLLAKPGV DSKAGRAILS
60 70 80 90 100
RLGVDRSVDY LLGDNDDAYQ TFQHHRSQVQ ERHGTDVSCL LIDESQFLTE
110 120 130 140 150
HQVNDLMRIA VLDNIPVICY GIRTDFRTSA FPGSRRLLEI AHSLEELKTI
160 170 180 190 200
CRCGRKAVFN ARCAHGTYIF EGDQVAIDGM EVTYESLCAT CYLRESGGRL

NREWHVAQD
Length:209
Mass (Da):23,558
Last modified:October 13, 2009 - v1
Checksum:i4E866ACEEDB1AA6A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001706 Genomic DNA. Translation: ACV09222.1.
RefSeqiWP_015771850.1. NC_013174.1.
YP_003161525.1. NC_013174.1.

Genome annotation databases

EnsemblBacteriaiACV09222; ACV09222; Jden_1574.
GeneIDi8380743.
KEGGijde:Jden_1574.
PATRICi22163333. VBIJonDen9837_1647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001706 Genomic DNA. Translation: ACV09222.1 .
RefSeqi WP_015771850.1. NC_013174.1.
YP_003161525.1. NC_013174.1.

3D structure databases

ProteinModelPortali C7R5E9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471856.Jden_1574.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACV09222 ; ACV09222 ; Jden_1574 .
GeneIDi 8380743.
KEGGi jde:Jden_1574.
PATRICi 22163333. VBIJonDen9837_1647.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076391.
KOi K00857.
OMAi ELKTVCH.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci JDEN471856:GH77-1623-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14870 / DSM 20603 / CIP 55134Imported.

Entry informationi

Entry nameiC7R5E9_JONDD
AccessioniPrimary (citable) accession number: C7R5E9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3