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Protein

Thymidine kinase

Gene

tdk

Organism
Jonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Proton acceptorUniRule annotation1
Metal bindingi151ZincUniRule annotation1
Metal bindingi153ZincUniRule annotation1
Metal bindingi188ZincUniRule annotation1
Metal bindingi191ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi93 – 96ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Jden_1574Imported
OrganismiJonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans)Imported
Taxonomic identifieri471856 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesJonesiaceaeJonesia
Proteomesi
  • UP000000628 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi471856.Jden_1574.

Structurei

3D structure databases

ProteinModelPortaliC7R5E9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107W53. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076391.
KOiK00857.
OMAiRATHNAR.
OrthoDBiPOG091H0659.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

C7R5E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLYFRYGA MNSGKSTALL QAAHNYEERG HQVLLAKPGV DSKAGRAILS
60 70 80 90 100
RLGVDRSVDY LLGDNDDAYQ TFQHHRSQVQ ERHGTDVSCL LIDESQFLTE
110 120 130 140 150
HQVNDLMRIA VLDNIPVICY GIRTDFRTSA FPGSRRLLEI AHSLEELKTI
160 170 180 190 200
CRCGRKAVFN ARCAHGTYIF EGDQVAIDGM EVTYESLCAT CYLRESGGRL

NREWHVAQD
Length:209
Mass (Da):23,558
Last modified:October 13, 2009 - v1
Checksum:i4E866ACEEDB1AA6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001706 Genomic DNA. Translation: ACV09222.1.
RefSeqiWP_015771850.1. NC_013174.1.

Genome annotation databases

EnsemblBacteriaiACV09222; ACV09222; Jden_1574.
KEGGijde:Jden_1574.
PATRICi22163333. VBIJonDen9837_1647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001706 Genomic DNA. Translation: ACV09222.1.
RefSeqiWP_015771850.1. NC_013174.1.

3D structure databases

ProteinModelPortaliC7R5E9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471856.Jden_1574.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV09222; ACV09222; Jden_1574.
KEGGijde:Jden_1574.
PATRICi22163333. VBIJonDen9837_1647.

Phylogenomic databases

eggNOGiENOG4107W53. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076391.
KOiK00857.
OMAiRATHNAR.
OrthoDBiPOG091H0659.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC7R5E9_JONDD
AccessioniPrimary (citable) accession number: C7R5E9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 30, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.