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Protein

Thymidine kinase

Gene

tdk

Organism
Jonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei94Proton acceptorUniRule annotation1
Metal bindingi151ZincUniRule annotation1
Metal bindingi153ZincUniRule annotation1
Metal bindingi188ZincUniRule annotation1
Metal bindingi191ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi93 – 96ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciJDEN471856:G1GFQ-1587-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Jden_1574Imported
OrganismiJonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans)Imported
Taxonomic identifieri471856 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesJonesiaceaeJonesia
Proteomesi
  • UP000000628 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi471856.Jden_1574

Structurei

3D structure databases

ProteinModelPortaliC7R5E9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107W53 Bacteria
COG1435 LUCA
HOGENOMiHOG000076391
KOiK00857
OMAiRATHNAR
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

C7R5E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLYFRYGA MNSGKSTALL QAAHNYEERG HQVLLAKPGV DSKAGRAILS
60 70 80 90 100
RLGVDRSVDY LLGDNDDAYQ TFQHHRSQVQ ERHGTDVSCL LIDESQFLTE
110 120 130 140 150
HQVNDLMRIA VLDNIPVICY GIRTDFRTSA FPGSRRLLEI AHSLEELKTI
160 170 180 190 200
CRCGRKAVFN ARCAHGTYIF EGDQVAIDGM EVTYESLCAT CYLRESGGRL

NREWHVAQD
Length:209
Mass (Da):23,558
Last modified:October 13, 2009 - v1
Checksum:i4E866ACEEDB1AA6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001706 Genomic DNA Translation: ACV09222.1
RefSeqiWP_015771850.1, NC_013174.1

Genome annotation databases

EnsemblBacteriaiACV09222; ACV09222; Jden_1574
KEGGijde:Jden_1574

Similar proteinsi

Entry informationi

Entry nameiC7R5E9_JONDD
AccessioniPrimary (citable) accession number: C7R5E9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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