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C7R4J5 (C7R4J5_JONDD) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
EC=2.2.1.7 HAMAP MF_00315
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase HAMAP MF_00315
Gene names
Name:dxs HAMAP MF_00315
Ordered Locus Names:Jden_1399
OrganismJonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans) [Complete proteome] [HAMAP]
Taxonomic identifier471856 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Jonesiaceae › Jonesia

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315 SAAS SAAS005477

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315 SAAS SAAS005477

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315 SAAS SAAS005477

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315 SAAS SAAS005477

Subunit structure

Homodimer By similarity. HAMAP MF_00315 SAAS SAAS005477

Sequence similarities

Belongs to the transketolase family. DXPS subfamily. HAMAP MF_00315

Sequences

Sequence LengthMass (Da)Tools
C7R4J5 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: C0962BE6A76F165B

FASTA63868,519
        10         20         30         40         50         60 
MGYLDEVGSP TDLKRLSQDQ VQDLAQEIRD YLVKSVSLTG GHLGPNLGVV ELTLAMHRVF 

        70         80         90        100        110        120 
HSPKDSFIFD TGHQSYVHKL VTGRRDFSNL RKQDGLSGYP SRAESDHDVV ENSHASTALS 

       130        140        150        160        170        180 
WADGIARANV VRGIDDRHVV AVIGDGALTG GMAWEALNNI AESDDRRLVI IVNDNGRSYS 

       190        200        210        220        230        240 
PTIGGLARHL DTLRTTRQYE GMLSWGKRNL PRLGIPGQML YDGLHGMKKG VKNIIRPQGW 

       250        260        270        280        290        300 
FEDLGIKYLG PIDGHDLGDL EHAFRRAQAF GGPVLVHVIT EKGRGYRPAE QDLADRFHAV 

       310        320        330        340        350        360 
GQIHPETGLP VAPARFGWTK VFADEIVKIG RSRSDVVALT AAMLQPVGLL PFSREFPQRT 

       370        380        390        400        410        420 
FDVGIAEQHA ATAAAGMAFA GLHPVVALYA TFLNRAFDQV LMDVALHRAG VTFVLDRAGI 

       430        440        450        460        470        480 
TGDDGASHNG MWDLALMRIV PGIQVAAPRD EETLRSSLRE AVTVDDGPTV VRYPKGAMGD 

       490        500        510        520        530        540 
PLPAVEVRHG IDVLARFGVD DQLSDGGQPR VVMVAVGAMA PLVIEAAQKV AVAGYQVEVL 

       550        560        570        580        590        600 
APTWVIPVSN GLLECVRGSD LVVTVEDGVV RGGVGALIAE TVRDHGVGVP VHSMGISSTF 

       610        620        630 
LDHAARAAIL DDHGLTEQGI ADATLAVLAR DRDSAVGD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001706 Genomic DNA. Translation: ACV09052.1.
RefSeqYP_003161355.1. NC_013174.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGC7R4J5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8380573.
GenomeReviewsGene locus Jden_1399 in contig CP001706_GR.
KEGGjde:Jden_1399.
PATRIC22162948. VBIJonDen9837_1459.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAQYDISYM.
ProtClustDBCLSK2547862.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR011766. TPP_enzyme-bd_C.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7R4J5_JONDD
AccessionPrimary (citable) accession number: C7R4J5
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: December 14, 2011
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info