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C7R446 (C7R446_JONDD) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UvrABC system protein B HAMAP-Rule MF_00204
Short name=Protein UvrB HAMAP-Rule MF_00204
Alternative name(s):
Excinuclease ABC subunit B HAMAP-Rule MF_00204
Gene names
Name:uvrB HAMAP-Rule MF_00204
Ordered Locus Names:Jden_1247
OrganismJonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans) [Complete proteome] [HAMAP]
Taxonomic identifier471856 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Jonesiaceae › Jonesia ›

Protein attributes

Sequence length702 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage By similarity. HAMAP-Rule MF_00204 SAAS SAAS024759

Subunit structure

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex By similarity. HAMAP-Rule MF_00204 RuleBase RU003587 SAAS SAAS024759

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00204 RuleBase RU003587 SAAS SAAS024759.

Domain

The beta-hairpin motif is involved in DNA binding By similarity. HAMAP-Rule MF_00204

Sequence similarities

Belongs to the UvrB family. HAMAP-Rule MF_00204 RuleBase RU003587

Contains 1 UVR domain. HAMAP-Rule MF_00204 RuleBase RU003587 SAAS SAAS024759

Contains 1 helicase ATP-binding domain. HAMAP-Rule MF_00204 SAAS SAAS024759

Contains 1 helicase C-terminal domain. HAMAP-Rule MF_00204 SAAS SAAS024759

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain48 – 232185Helicase ATP-binding By similarity HAMAP-Rule MF_00204
Domain451 – 617167Helicase C-terminal By similarity HAMAP-Rule MF_00204
Domain658 – 69336UVR By similarity HAMAP-Rule MF_00204
Nucleotide binding61 – 688ATP By similarity HAMAP-Rule MF_00204
Motif114 – 13724Beta-hairpin By similarity HAMAP-Rule MF_00204

Sequences

Sequence LengthMass (Da)Tools
C7R446 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: CAF4E5A3A3F73333

FASTA70278,779
        10         20         30         40         50         60 
MVRGVRGGHY VGCMSSHREL TRVDFQFDVV SEFSPSGDQP SAIAELTRRI QGGEKDVVLL 

        70         80         90        100        110        120 
GATGTGKSAT SAWLIEQLQR PTLIMAPNKT LAAQLATEFR ELLPNNAVEY FVSYYDYYQP 

       130        140        150        160        170        180 
EAYIAQTDTY IEKDSSINEE VERLRHSATN SLLTRRDVVV VASVSCIYGL GTPQEYVDRM 

       190        200        210        220        230        240 
VQIDVGDEID RDGLLRHFVS MQYTRNDVAF TRGTFRVRGD TVEIIPVYEE LAIRLEFFGD 

       250        260        270        280        290        300 
DIEAIYTLHP LTGEVVSQVQ RIHIFPASHY VAGPERMERA IASIEAELEE RLAELNRDNK 

       310        320        330        340        350        360 
LLEAQRLSMR TTYDIEMMRQ VGSCSGIENY SRHIDGRAPG SAPHTLLDYF PDDFLLIIDE 

       370        380        390        400        410        420 
SHVTVPQIGA MYEGDASRKR SLVEHGFRLP SAMDNRPLTW EEFTERIGQT VYLSATPGDY 

       430        440        450        460        470        480 
ELALSNGTVE QIIRPTGLVD PKITVKPTKG QIDDLLDEIN ERTAKNERIL VTTLTKKMSE 

       490        500        510        520        530        540 
DLTDYLLDKG VAVRYLHSDI DTLKRVELLR GLRLGEFDVL VGINLLREGL DLPEVSLVAI 

       550        560        570        580        590        600 
LDADKQGFLR SPRSLIQTIG RAARNVSGEV HMYADSITPA MAQAIEETER RREKQIAYNT 

       610        620        630        640        650        660 
EHGVDPQPLR KKIADVTDML AREDIDTQEL LAGGYRQTTT PTPAHTPSGV PSATGDLSAL 

       670        680        690        700 
ITQLTEQMHQ AAAELQFELA ARLRDELSDL KRELRQMKDA TS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001706 Genomic DNA. Translation: ACV08903.1.
RefSeqYP_003161206.1. NC_013174.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING471856.Jden_1247.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV08903; ACV08903; Jden_1247.
GeneID8380424.
KEGGjde:Jden_1247.
PATRIC22162624. VBIJonDen9837_1303.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0556.
HOGENOMHOG000073580.
KOK03702.
OMACIYGLGI.
ProtClustDBPRK05298.

Enzyme and pathway databases

BioCycJDEN471856:GH77-1224-MONOMER.

Family and domain databases

Gene3D4.10.860.10. 1 hit.
HAMAPMF_00204. UvrB.
InterProIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view]
PANTHERPTHR24029. PTHR24029. 1 hit.
PfamPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF46600. UvrB_C. 1 hit.
TIGRFAMsTIGR00631. uvrb. 1 hit.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7R446_JONDD
AccessionPrimary (citable) accession number: C7R446
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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