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Protein

Acetate kinase

Gene

ackA

Organism
Jonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg(2+). Can also accept Mn2+.UniRule annotation

Pathway:iacetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (Jden_0643)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi10 – 101MagnesiumUniRule annotation
Binding sitei17 – 171ATPUniRule annotation
Binding sitei91 – 911SubstrateUniRule annotation
Active sitei148 – 1481Proton donor/acceptorUniRule annotation
Sitei180 – 1801Transition state stabilizerUniRule annotation
Sitei241 – 2411Transition state stabilizerUniRule annotation
Metal bindingi385 – 3851MagnesiumUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi208 – 2125ATPUniRule annotation
Nucleotide bindingi282 – 2843ATPUniRule annotation
Nucleotide bindingi331 – 3355ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciJDEN471856:GH77-660-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:Jden_0642Imported
OrganismiJonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans)Imported
Taxonomic identifieri471856 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesJonesiaceaeJonesia
ProteomesiUP000000628 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi471856.Jden_0642.

Structurei

3D structure databases

ProteinModelPortaliC7R191.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0282.
HOGENOMiHOG000288399.
KOiK00925.
OMAiKIITCHI.
OrthoDBiEOG69975F.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7R191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHATVLVIN AGSSTIKYQL VDPTSGEAIA GGLVERIGES NGLVEHRYHG
60 70 80 90 100
EEHSEELPIT DHGHGLREVL RLFDTHGPRL ADAHIVAVGH RVVQGGSVFP
110 120 130 140 150
HPTVVDDDVV EKIRDLIPLA PLHNPGSVRG IEVARELFSD IPHVVVFDTS
160 170 180 190 200
FFQTMPASAY TYALPKDLAA EHSIRRYGFH GTSHQYVSEQ AALLLGRDLT
210 220 230 240 250
SFNQIVAHLG SGASISAIAG GTAVDTSMGL TPLEGLVMGT RTGDMDPAIV
260 270 280 290 300
LHLQRAAGLS IDEVNTLLNK ESGLKGLCGN NDFREVLAMI EAGNQDAALA
310 320 330 340 350
FDVYVHRLVK YIGSYMAVLG GLPEVITFTA GVGENNALIR ERVADALAGF
360 370 380 390
GVRIDKEANA VRSKEARIVS TPDSTVAVAV IPTNEELAIA RQTLALVEA
Length:399
Mass (Da):42,517
Last modified:October 13, 2009 - v1
Checksum:iCFE10FEF9B9ECD48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001706 Genomic DNA. Translation: ACV08306.1.
RefSeqiWP_015770934.1. NC_013174.1.

Genome annotation databases

EnsemblBacteriaiACV08306; ACV08306; Jden_0642.
KEGGijde:Jden_0642.
PATRICi22161332. VBIJonDen9837_0674.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001706 Genomic DNA. Translation: ACV08306.1.
RefSeqiWP_015770934.1. NC_013174.1.

3D structure databases

ProteinModelPortaliC7R191.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471856.Jden_0642.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV08306; ACV08306; Jden_0642.
KEGGijde:Jden_0642.
PATRICi22161332. VBIJonDen9837_0674.

Phylogenomic databases

eggNOGiCOG0282.
HOGENOMiHOG000288399.
KOiK00925.
OMAiKIITCHI.
OrthoDBiEOG69975F.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.
BioCyciJDEN471856:GH77-660-MONOMER.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase.
InterProiIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14870 / DSM 20603 / CIP 55134Imported.

Entry informationi

Entry nameiC7R191_JONDD
AccessioniPrimary (citable) accession number: C7R191
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: July 22, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.