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Protein

Acetate kinase

Gene

ackA

Organism
Jonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (Jden_0643)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi10MagnesiumUniRule annotation1
Binding sitei17ATPUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Active sitei148Proton donor/acceptorUniRule annotation1
Sitei180Transition state stabilizerUniRule annotation1
Sitei241Transition state stabilizerUniRule annotation1
Metal bindingi385MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi208 – 212ATPUniRule annotation5
Nucleotide bindingi282 – 284ATPUniRule annotation3
Nucleotide bindingi331 – 335ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciJDEN471856:G1GFQ-643-MONOMER
UniPathwayiUPA00340; UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:Jden_0642Imported
OrganismiJonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans)Imported
Taxonomic identifieri471856 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesJonesiaceaeJonesia
Proteomesi
  • UP000000628 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi471856.Jden_0642

Structurei

3D structure databases

ProteinModelPortaliC7R191
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C6H Bacteria
COG0282 LUCA
HOGENOMiHOG000288399
KOiK00925
OMAiWKALTGT
OrthoDBiPOG091H02K4

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

C7R191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHATVLVIN AGSSTIKYQL VDPTSGEAIA GGLVERIGES NGLVEHRYHG
60 70 80 90 100
EEHSEELPIT DHGHGLREVL RLFDTHGPRL ADAHIVAVGH RVVQGGSVFP
110 120 130 140 150
HPTVVDDDVV EKIRDLIPLA PLHNPGSVRG IEVARELFSD IPHVVVFDTS
160 170 180 190 200
FFQTMPASAY TYALPKDLAA EHSIRRYGFH GTSHQYVSEQ AALLLGRDLT
210 220 230 240 250
SFNQIVAHLG SGASISAIAG GTAVDTSMGL TPLEGLVMGT RTGDMDPAIV
260 270 280 290 300
LHLQRAAGLS IDEVNTLLNK ESGLKGLCGN NDFREVLAMI EAGNQDAALA
310 320 330 340 350
FDVYVHRLVK YIGSYMAVLG GLPEVITFTA GVGENNALIR ERVADALAGF
360 370 380 390
GVRIDKEANA VRSKEARIVS TPDSTVAVAV IPTNEELAIA RQTLALVEA
Length:399
Mass (Da):42,517
Last modified:October 13, 2009 - v1
Checksum:iCFE10FEF9B9ECD48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001706 Genomic DNA Translation: ACV08306.1
RefSeqiWP_015770934.1, NC_013174.1

Genome annotation databases

EnsemblBacteriaiACV08306; ACV08306; Jden_0642
KEGGijde:Jden_0642

Similar proteinsi

Entry informationi

Entry nameiC7R191_JONDD
AccessioniPrimary (citable) accession number: C7R191
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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