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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Jonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei16 – 1611D-inositol 3-phosphateUniRule annotation
Binding sitei30 – 301UDP-GlcNAc; via amide nitrogenUniRule annotation
Binding sitei85 – 8511D-inositol 3-phosphateUniRule annotation
Binding sitei118 – 11811D-inositol 3-phosphateUniRule annotation
Binding sitei142 – 14211D-inositol 3-phosphateUniRule annotation
Binding sitei162 – 16211D-inositol 3-phosphateUniRule annotation
Binding sitei240 – 2401UDP-GlcNAcUniRule annotation
Binding sitei245 – 2451UDP-GlcNAcUniRule annotation
Metal bindingi313 – 3131Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi314 – 3141Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi316 – 3161Magnesium; via carbonyl oxygenUniRule annotation
Binding sitei326 – 3261UDP-GlcNAcUniRule annotation
Binding sitei334 – 3341UDP-GlcNAcUniRule annotation
Metal bindingi340 – 3401MagnesiumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciJDEN471856:GH77-2149-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:Jden_2087
OrganismiJonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans)
Taxonomic identifieri471856 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesJonesiaceaeJonesia
Proteomesi
  • UP000000628 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424D-inositol 3-phosphate glycosyltransferasePRO_0000400127Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi471856.Jden_2087.

Structurei

3D structure databases

ProteinModelPortaliC7R101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 232UDP-GlcNAc bindingUniRule annotation
Regioni27 – 3261D-inositol 3-phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiEOG647TVR.

Family and domain databases

HAMAPiMF_01695. MshA.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.

Sequencei

Sequence statusi: Complete.

C7R101-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVSHPAHRV AMLCVHTSPL AQPGTGDAGG MNVYVVELAR AMAAQGTEVE
60 70 80 90 100
IFTRRTTANQ PDVVEVDDGV LVRHVTAGPY EGLDKNDLPG QLCYFTQGVL
110 120 130 140 150
RTEAARQPGW YDIVHSHYWL SGQAGWLAAD RWNVPLVHTM HTMARVKNAQ
160 170 180 190 200
LAPGDAPEPR ARIIGEEQVV EQSAALVANT DKEAHELHTL YAADPEKVHV
210 220 230 240 250
VAPGVDLAAF TPPIDDHQRQ AERVALGLAP EGDVIVFAGR IQPLKGPDVL
260 270 280 290 300
VDALALLRSQ QPDRPMPTLV IIGGPSGRPA ALGELRARVF QRGVAQHVRF
310 320 330 340 350
VPPADRPTLA QWMRVADYVA MPSRNESFGL VAIEAQACGT PVIAADVGGL
360 370 380 390 400
TTAVAHKKSG LLVPDHRPQT WAGVLQVALG DTQLRESLRA GARRHAQQFT
410 420
WDHTATDMLA VYERTRVAAS VNTG
Length:424
Mass (Da):45,743
Last modified:October 13, 2009 - v1
Checksum:i70DCD8EEA84C22A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001706 Genomic DNA. Translation: ACV09725.1.
RefSeqiWP_015772353.1. NC_013174.1.

Genome annotation databases

EnsemblBacteriaiACV09725; ACV09725; Jden_2087.
KEGGijde:Jden_2087.
PATRICi22164427. VBIJonDen9837_2182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001706 Genomic DNA. Translation: ACV09725.1.
RefSeqiWP_015772353.1. NC_013174.1.

3D structure databases

ProteinModelPortaliC7R101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471856.Jden_2087.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACV09725; ACV09725; Jden_2087.
KEGGijde:Jden_2087.
PATRICi22164427. VBIJonDen9837_2182.

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiEOG647TVR.

Enzyme and pathway databases

BioCyciJDEN471856:GH77-2149-MONOMER.

Family and domain databases

HAMAPiMF_01695. MshA.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14870 / DSM 20603 / CIP 55134.

Entry informationi

Entry nameiMSHA_JONDD
AccessioniPrimary (citable) accession number: C7R101
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: October 13, 2009
Last modified: May 11, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.