Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

C7QYT8 (C7QYT8_JONDD) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Jden_1680 EMBL ACV09327.1
OrganismJonesia denitrificans (strain ATCC 14870 / DSM 20603 / CIP 55134) (Listeria denitrificans) [Complete proteome] [HAMAP] EMBL ACV09327.1
Taxonomic identifier471856 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeJonesiaceaeJonesia

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain168 – 379212ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding200 – 25556ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3331Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3461Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3461Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3481Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C7QYT8 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 26959C787BC7A099

FASTA38941,494
        10         20         30         40         50         60 
MENMSTSQTR PNNLGAPHAA DRVRTRVLVL FGGRSGEHPI SCITAAGVLR AIDRDRFDVV 

        70         80         90        100        110        120 
AVGITQGGKW VLASTDPDEV VTSGDDLPHV ADNGTEVLLP FASGDNEVRV IRDGVLESVG 

       130        140        150        160        170        180 
PVDVVLPLLH GPFGEDGTVQ GMLELADLRY VGVGVLGSAV GMDKHYMKLV FEGHGLPVGP 

       190        200        210        220        230        240 
YTTVFPGQWQ RDPDEVRARV VALGLPVFVK PTRAGSSLGI SKVSDVGDLD RAMAEALKHD 

       250        260        270        280        290        300 
PKVIIEAGIV GREIECAVLG GHGDTPARAS LPGEITMTGS AHEFYDFEAK YLDDASAQLS 

       310        320        330        340        350        360 
CPAELDETTT ATVREVAVRA FDAVGGEGLS RVDVFVQEDG AVVVNEINTM PGFTPISMYP 

       370        380 
RMWERSGVSY TELISELIDL ALERPLGLR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001706 Genomic DNA. Translation: ACV09327.1.
RefSeqYP_003161630.1. NC_013174.1.

3D structure databases

ProteinModelPortalC7QYT8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING471856.Jden_1680.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV09327; ACV09327; Jden_1680.
GeneID8380848.
KEGGjde:Jden_1680.
PATRIC22163549. VBIJonDen9837_1754.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBCLSK2818721.

Enzyme and pathway databases

BioCycJDEN471856:GH77-1730-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7QYT8_JONDD
AccessionPrimary (citable) accession number: C7QYT8
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)