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C7QNR3 (C7QNR3_CYAP0) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UvrABC system protein B HAMAP-Rule MF_00204
Short name=Protein UvrB HAMAP-Rule MF_00204
Alternative name(s):
Excinuclease ABC subunit B HAMAP-Rule MF_00204
Gene names
Name:uvrB HAMAP-Rule MF_00204
Ordered Locus Names:Cyan8802_3723 EMBL ACV02535.1
OrganismCyanothece sp. (strain PCC 8802) (Synechococcus sp. (strain RF-2)) [Complete proteome] [HAMAP] EMBL ACV02535.1
Taxonomic identifier395962 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Cyanothece

Protein attributes

Sequence length667 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage By similarity. HAMAP-Rule MF_00204 SAAS SAAS024759

Subunit structure

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex By similarity. HAMAP-Rule MF_00204 RuleBase RU003587 SAAS SAAS024759

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00204 RuleBase RU003587 SAAS SAAS024759.

Domain

The beta-hairpin motif is involved in DNA binding By similarity. HAMAP-Rule MF_00204

Sequence similarities

Belongs to the UvrB family. HAMAP-Rule MF_00204 RuleBase RU003587

Contains 1 UVR domain. HAMAP-Rule MF_00204 RuleBase RU003587 SAAS SAAS024759

Contains 1 helicase ATP-binding domain. HAMAP-Rule MF_00204 SAAS SAAS024759

Contains 1 helicase C-terminal domain. HAMAP-Rule MF_00204 SAAS SAAS024759

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain27 – 178152Helicase ATP-binding By similarity HAMAP-Rule MF_00204
Domain431 – 585155Helicase C-terminal By similarity HAMAP-Rule MF_00204
Domain628 – 66336UVR By similarity HAMAP-Rule MF_00204
Nucleotide binding40 – 478ATP By similarity HAMAP-Rule MF_00204
Motif93 – 11624Beta-hairpin By similarity HAMAP-Rule MF_00204

Sequences

Sequence LengthMass (Da)Tools
C7QNR3 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: 17F8FFC511AFC716

FASTA66776,340
        10         20         30         40         50         60 
MTFSSFRLQA PFEPQGDQPQ AIAQLLASLQ AGNRFQTLLG ATGTGKTFSI ASVIEKVGKP 

        70         80         90        100        110        120 
TLVLAHNKTL AAQLCNELRQ FFPDNAVEYF ISYYDYYQPE AYIPVSDTYI EKSSSINDEI 

       130        140        150        160        170        180 
DMLRHSATRS LFERKDVIVV ASISCIYGLG MPSEYLKAAV PLEVGQEVDQ RNLLRELVGI 

       190        200        210        220        230        240 
QYSRNDIELQ RGRFRVKGDV LEIVPAYEDR IIRVEFFGDE IEAIRYLDPV TGEILQSLKM 

       250        260        270        280        290        300 
VNIYPARHFV TPDEQIEIAC QQIKVELEEQ IEALEKEGKL LEAQRISQRT RYDLDLLQEV 

       310        320        330        340        350        360 
GYCNGVENYS RYLAGRKAGE PPECLIDYFP QDWLLVVDES HVTVPQLRGM YNGDRSRKQV 

       370        380        390        400        410        420 
LIDHGFRLPS AADNRPLKSE EFWTKVNQCI FVSATPGDWE IEQSGDRIIE QIIRPTGVLD 

       430        440        450        460        470        480 
PEIFVRPTEG QVDDLLGEIK QRVKRQERVL ITTLTKRMSE DLTEYLSERG VKVQYLHSEV 

       490        500        510        520        530        540 
KSIERIEILQ SLRKGEFDVL IGVNLLREGL DLPEVSLVAI LDADKEGFLR AERSLIQTIG 

       550        560        570        580        590        600 
RAARHVNGQA ILYADNLTKS MIKAIEETER RRGIQMAHNK INNITPKPII KKETNSILSF 

       610        620        630        640        650        660 
LDISRRLNSQ QLEEIYEKSD DLPLEKVPEL IQQLENQMKE AAQKLEFEEA AKYRDRIKNL 


RDKLLGN

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References

[1]"Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 8802.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001701 Genomic DNA. Translation: ACV02535.1.
RefSeqYP_003139370.1. NC_013161.1.

3D structure databases

ProteinModelPortalC7QNR3.
SMRC7QNR3. Positions 6-655.
ModBaseSearch...

Protein-protein interaction databases

STRING395962.Cyan8802_3723.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACV02535; ACV02535; Cyan8802_3723.
GeneID8393071.
KEGGcyh:Cyan8802_3723.
PATRIC21589089. VBICyaSp112625_3838.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0556.
HOGENOMHOG000073580.
KOK03702.
OMACIYGLGI.
ProtClustDBPRK05298.

Enzyme and pathway databases

BioCycCSP395962:GJC3-3768-MONOMER.

Family and domain databases

Gene3D4.10.860.10. 1 hit.
HAMAPMF_00204. UvrB.
InterProIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view]
PANTHERPTHR24029. PTHR24029. 1 hit.
PfamPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
TIGRFAMsTIGR00631. uvrb. 1 hit.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7QNR3_CYAP0
AccessionPrimary (citable) accession number: C7QNR3
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info