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Protein

Alanine racemase

Gene

Cyan8802_0923

Organism
Cyanothece sp. (strain PCC 8802) (Synechococcus sp. (strain RF-2))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei58 – 581Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei157 – 1571SubstrateUniRule annotation
Active sitei286 – 2861Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei334 – 3341Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCSP395962:GJC3-929-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Cyan8802_0923Imported
OrganismiCyanothece sp. (strain PCC 8802) (Synechococcus sp. (strain RF-2))Imported
Taxonomic identifieri395962 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesCyanothece
ProteomesiUP000000415: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi395962.Cyan8802_0923.

Structurei

3D structure databases

ProteinModelPortaliC7QL14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiITMDQLM.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7QL14-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSQELETKT RRNRYDYHLS EIIRQRAWVE INQQALIHNV AEIKGLLSPK
60 70 80 90 100
TALMAVVKAD AYGHGAIKVA QTALDAGANG LAIATLGEGI ELREAGITAP
110 120 130 140 150
ILILGAINTP EEIAAIAQWQ LQPTLCNPQQ ALIFSGTLSK LGQTLPVHLK
160 170 180 190 200
LDTGMSRLGT PWHQATDFVR LVQQLPYLKI ATIYSHLATA DDPDRSEMER
210 220 230 240 250
QHRRFKQAIA QLKSHGLPLP PLHFANSAAT LVNPNLHYDL VRVGLALYGL
260 270 280 290 300
YPAPHLRSFA DLKPVLQVKA KVTQVKTIPP GTGVSYGYQF VSDRTMDVAV
310 320 330 340 350
VGIGYADGVP RNLSNRLEVL IRGQRVRQIG AITMDQLMLD VSAIPNLQVG
360 370 380 390 400
EVVTLIGKDG DQEITADDWA NKLGTISWEI LCGFKHRLPR IMVKSSSNKL

VEI
Length:403
Mass (Da):44,275
Last modified:October 13, 2009 - v1
Checksum:i00BDFB542F6C3394
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001701 Genomic DNA. Translation: ACU99857.1.
RefSeqiWP_015783381.1. NC_013161.1.
YP_003136693.1. NC_013161.1.

Genome annotation databases

EnsemblBacteriaiACU99857; ACU99857; Cyan8802_0923.
GeneIDi8390232.
KEGGicyh:Cyan8802_0923.
PATRICi21583338. VBICyaSp112625_1002.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001701 Genomic DNA. Translation: ACU99857.1.
RefSeqiWP_015783381.1. NC_013161.1.
YP_003136693.1. NC_013161.1.

3D structure databases

ProteinModelPortaliC7QL14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi395962.Cyan8802_0923.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACU99857; ACU99857; Cyan8802_0923.
GeneIDi8390232.
KEGGicyh:Cyan8802_0923.
PATRICi21583338. VBICyaSp112625_1002.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiITMDQLM.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciCSP395962:GJC3-929-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Novel metabolic attributes of the genus Cyanothece, comprising a group of unicellular nitrogen-fixing Cyanobacteria."
    Bandyopadhyay A., Elvitigala T., Welsh E., Stockel J., Liberton M., Min H., Sherman L.A., Pakrasi H.B.
    MBio 2:E214-E214(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 8802Imported.

Entry informationi

Entry nameiC7QL14_CYAP0
AccessioniPrimary (citable) accession number: C7QL14
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 4, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.