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C7QH14 (C7QH14_CATAD) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Caci_8041 EMBL ACU76864.1
OrganismCatenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897) [Complete proteome] [HAMAP] EMBL ACU76864.1
Taxonomic identifier479433 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCatenulisporineaeCatenulisporaceaeCatenulispora

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain167 – 384218ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding201 – 25656ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3331Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3511Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3511Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3531Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C7QH14 [UniParc].

Last modified October 13, 2009. Version 1.
Checksum: C16A3C8A1A475C49

FASTA39441,965
        10         20         30         40         50         60 
MVSPMSDQKR IRVAVVFGGR SSEHAISCVT AGSVLDALRN GPEPQRYEIV PIGIASDGRW 

        70         80         90        100        110        120 
VLADLPDGGD LNLAITDGRL PEIGLPASAE RANLVTMAGD PTARELTVHE PGAVPKSLGE 

       130        140        150        160        170        180 
VDVVLPLLHG PYGEDGTLQG LLELAGVPYV GSGVLASAVS MDKEFMKRLL AQAGFEVGPY 

       190        200        210        220        230        240 
EVVRPRDWGT EEGRAAVRLA VEELGYPVFV KPARAGSSMG ITKVDAPEEL DQAIDAARRH 

       250        260        270        280        290        300 
DPKVLVEAAI EGREIECGVL EGAGPQDPAE ASLPAELRVT GPHAFYDFQA KYLDGSTEVD 

       310        320        330        340        350        360 
IPARLSAEEI EDIRGQAVGV FETLGCEGLA RVDFFYQESA DGGPGRFIVN EINTMPGFTP 

       370        380        390 
TSMFPQMWQA AGLSYPELIA RLIDTALLRP AGLR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001700 Genomic DNA. Translation: ACU76864.1.
RefSeqYP_003118705.1. NC_013131.1.

3D structure databases

ProteinModelPortalC7QH14.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING479433.Caci_8041.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACU76864; ACU76864; Caci_8041.
GeneID8339419.
KEGGcai:Caci_8041.
PATRIC21294860. VBICatAci36872_8161.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAIECGVLG.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycCACI479433:GI6Z-8094-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC7QH14_CATAD
AccessionPrimary (citable) accession number: C7QH14
Entry history
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)