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Protein

UvrABC system protein C

Gene

uvrC

Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. excinuclease ABC activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. nucleotide-excision repair Source: UniProtKB-HAMAP
  2. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nucleaseUniRule annotationSAAS annotation

Keywords - Biological processi

DNA damage, DNA excisionUniRule annotationSAAS annotation, DNA repair, SOS responseUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCACI479433:GI6Z-5649-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotationSAAS annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:Caci_5613Imported
OrganismiCatenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)Imported
Taxonomic identifieri479433 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCatenulisporineaeCatenulisporaceaeCatenulispora
ProteomesiUP000000851: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. excinuclease repair complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi479433.Caci_5613.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 9580GIY-YIGUniRule annotationAdd
BLAST
Domaini208 – 24336UVRUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation
Contains 1 GIY-YIG domain.UniRule annotation
Contains 1 UVR domain.UniRule annotation
Contains GIY-YIG domain.SAAS annotation
Contains UVR domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279962.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiEOG6K13R9.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7QAZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPATYRPK PGEIPTSPGV YKFRDPHSRV IYVGKAKNLR SRLTSYFQDL
60 70 80 90 100
ANLHVRTQTM VTTAASVEWT TVATEVEALQ LEYTWIKQFE PRFNVKYRDD
110 120 130 140 150
KSYPSLAVTV GEEFPRAQVM RGPKRPGVRY FGPYSHAWAI RETLDSLLRV
160 170 180 190 200
FPIRTCSSGV FKRAAQTGRP CLLGYIGKCS APCVGRVSAE EHREIVDDFV
210 220 230 240 250
SFMAGRTDRY IRGLEEEMKE AAKELEFEKA ARLRDDLQAL KQSLEKNAVV
260 270 280 290 300
LGDGTDADVI ALSEDPLEAA VQVFHVRGGR IRGQRGWVVD RVEDVDTAGL
310 320 330 340 350
VEHFMQQLYG SEQGEPGIDT ETVPREILVP ELPGSVEAIT EWLSARRGAK
360 370 380 390 400
VEVRIPKRGD KAALMETVAQ NAKQALALHK TRRASDLTTR SVALQELADA
410 420 430 440 450
IGMDQAPLRI ECYDISHLQG TNVVASMVVF EDGLPRKSEY RRFTIKGSDE
460 470 480 490 500
NGATNDDVRN MHEVITRRFK AFLKEQEEEK LIDATIGDRK KFSYPPQLVV
510 520 530 540 550
VDGGQPQVAA AARALADLEI SDVTLVGLAK RLEEVWLPDE DDPVLLPRSS
560 570 580 590 600
EGLYMLQRVR DEAHRFGIAF HRQKRSKSMV ASALDDVPGL GEVRRKALLA
610 620 630 640 650
HFGTLRKLRA AQVAEIAEVP GIGPATARQI HSALAELPVS RAVNAATGEI
660
LDGGESRNGP DEE
Length:663
Mass (Da):73,646
Last modified:October 13, 2009 - v1
Checksum:iA00C377ADDCB83A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001700 Genomic DNA. Translation: ACU74472.1.
RefSeqiYP_003116313.1. NC_013131.1.

Genome annotation databases

EnsemblBacteriaiACU74472; ACU74472; Caci_5613.
GeneIDi8336973.
KEGGicai:Caci_5613.
PATRICi21289927. VBICatAci36872_5711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001700 Genomic DNA. Translation: ACU74472.1.
RefSeqiYP_003116313.1. NC_013131.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi479433.Caci_5613.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACU74472; ACU74472; Caci_5613.
GeneIDi8336973.
KEGGicai:Caci_5613.
PATRICi21289927. VBICatAci36872_5711.

Phylogenomic databases

eggNOGiCOG0322.
HOGENOMiHOG000279962.
KOiK03703.
OMAiRCPGVCQ.
OrthoDBiEOG6K13R9.

Enzyme and pathway databases

BioCyciCACI479433:GI6Z-5649-MONOMER.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897Imported.

Entry informationi

Entry nameiC7QAZ9_CATAD
AccessioniPrimary (citable) accession number: C7QAZ9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: February 4, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.