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C7Q8T3

- C7Q8T3_CATAD

UniProt

C7Q8T3 - C7Q8T3_CATAD

Protein

Probable DNA ligase

Gene

lig

Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei224 – 2241ATPUniRule annotation
    Active sitei226 – 2261N6-AMP-lysine intermediateUniRule annotation
    Binding sitei231 – 2311ATPUniRule annotation
    Binding sitei246 – 2461ATPUniRule annotation
    Binding sitei275 – 2751ATPUniRule annotation
    Binding sitei315 – 3151ATPUniRule annotation
    Binding sitei387 – 3871ATPUniRule annotation
    Binding sitei393 – 3931ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCACI479433:GI6Z-1441-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Caci_1425Imported
    OrganismiCatenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)Imported
    Taxonomic identifieri479433 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCatenulisporineaeCatenulisporaceaeCatenulispora
    ProteomesiUP000000851: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi479433.Caci_1425.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK01971.
    OMAiVPIVIPY.
    OrthoDBiEOG6Q8HXT.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C7Q8T3-1 [UniParc]FASTAAdd to Basket

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    MRLHDVATTS AAVAETSARS AKIALLAERL RTATPEEVAV AVHYLSGELP    50
    QRQIGVGWAT LRELPAPADD SGGSNSSDGS DGSASTAGLE VAEVDRILEE 100
    IGKTTGAGSQ ARRRDLLTAL FARATAEEQA FLRRLLTGEL RQGALDGVMA 150
    DAVAKAADVP AAEVRRAAMF GGDLAAAAQT ALRAGVPGLR EVGLVVGRPI 200
    QPMLAGTAED VPTALAKASP AALEWKLDGI RVQIHRDGDR VQVFTRSLDD 250
    ITERLPEAVA LARSLQVTSA VLDGEALALA ADGRPRPFQE TASRTGSRRD 300
    VERMREQIPL TVFLFDLLHL DGRDLVDLPS RERSDLLASI APPAAVAPRL 350
    VTDDADAAEA FAKDALDRGH EGVVVKSLDA LYSAGRRGSG WLKVKPVHTL 400
    DLVVLAAEWG HGRRRGWLSN LHLAARDPET GGFVMLGKTF KGMTDELLTW 450
    QTERLRALQT SADDFAVHVR PELVVEVAFD GVQRSSRYPG GVTLRFARVV 500
    RYREDKRAED ADTIDAVRAI GQGQEQA 527
    Length:527
    Mass (Da):56,425
    Last modified:October 13, 2009 - v1
    Checksum:iD45A9D33F9221C3B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001700 Genomic DNA. Translation: ACU70348.1.
    RefSeqiYP_003112189.1. NC_013131.1.

    Genome annotation databases

    EnsemblBacteriaiACU70348; ACU70348; Caci_1425.
    GeneIDi8332764.
    KEGGicai:Caci_1425.
    PATRICi21281360. VBICatAci36872_1442.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001700 Genomic DNA. Translation: ACU70348.1 .
    RefSeqi YP_003112189.1. NC_013131.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 479433.Caci_1425.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACU70348 ; ACU70348 ; Caci_1425 .
    GeneIDi 8332764.
    KEGGi cai:Caci_1425.
    PATRICi 21281360. VBICatAci36872_1442.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K01971.
    OMAi VPIVIPY.
    OrthoDBi EOG6Q8HXT.

    Enzyme and pathway databases

    BioCyci CACI479433:GI6Z-1441-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897Imported.

    Entry informationi

    Entry nameiC7Q8T3_CATAD
    AccessioniPrimary (citable) accession number: C7Q8T3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 13, 2009
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3