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C7Q8T3

- C7Q8T3_CATAD

UniProt

C7Q8T3 - C7Q8T3_CATAD

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Protein

Probable DNA ligase

Gene

lig

Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Note: Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei224 – 2241ATPUniRule annotation
Active sitei226 – 2261N6-AMP-lysine intermediateUniRule annotation
Binding sitei231 – 2311ATPUniRule annotation
Binding sitei246 – 2461ATPUniRule annotation
Binding sitei275 – 2751ATPUniRule annotation
Binding sitei315 – 3151ATPUniRule annotation
Binding sitei387 – 3871ATPUniRule annotation
Binding sitei393 – 3931ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCACI479433:GI6Z-1441-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Caci_1425Imported
OrganismiCatenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)Imported
Taxonomic identifieri479433 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCatenulisporineaeCatenulisporaceaeCatenulispora
ProteomesiUP000000851: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi479433.Caci_1425.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK01971.
OMAiVPIVIPY.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7Q8T3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLHDVATTS AAVAETSARS AKIALLAERL RTATPEEVAV AVHYLSGELP
60 70 80 90 100
QRQIGVGWAT LRELPAPADD SGGSNSSDGS DGSASTAGLE VAEVDRILEE
110 120 130 140 150
IGKTTGAGSQ ARRRDLLTAL FARATAEEQA FLRRLLTGEL RQGALDGVMA
160 170 180 190 200
DAVAKAADVP AAEVRRAAMF GGDLAAAAQT ALRAGVPGLR EVGLVVGRPI
210 220 230 240 250
QPMLAGTAED VPTALAKASP AALEWKLDGI RVQIHRDGDR VQVFTRSLDD
260 270 280 290 300
ITERLPEAVA LARSLQVTSA VLDGEALALA ADGRPRPFQE TASRTGSRRD
310 320 330 340 350
VERMREQIPL TVFLFDLLHL DGRDLVDLPS RERSDLLASI APPAAVAPRL
360 370 380 390 400
VTDDADAAEA FAKDALDRGH EGVVVKSLDA LYSAGRRGSG WLKVKPVHTL
410 420 430 440 450
DLVVLAAEWG HGRRRGWLSN LHLAARDPET GGFVMLGKTF KGMTDELLTW
460 470 480 490 500
QTERLRALQT SADDFAVHVR PELVVEVAFD GVQRSSRYPG GVTLRFARVV
510 520
RYREDKRAED ADTIDAVRAI GQGQEQA
Length:527
Mass (Da):56,425
Last modified:October 13, 2009 - v1
Checksum:iD45A9D33F9221C3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001700 Genomic DNA. Translation: ACU70348.1.
RefSeqiWP_012785642.1. NC_013131.1.
YP_003112189.1. NC_013131.1.

Genome annotation databases

EnsemblBacteriaiACU70348; ACU70348; Caci_1425.
GeneIDi8332764.
KEGGicai:Caci_1425.
PATRICi21281360. VBICatAci36872_1442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001700 Genomic DNA. Translation: ACU70348.1 .
RefSeqi WP_012785642.1. NC_013131.1.
YP_003112189.1. NC_013131.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 479433.Caci_1425.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACU70348 ; ACU70348 ; Caci_1425 .
GeneIDi 8332764.
KEGGi cai:Caci_1425.
PATRICi 21281360. VBICatAci36872_1442.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K01971.
OMAi VPIVIPY.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci CACI479433:GI6Z-1441-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897Imported.

Entry informationi

Entry nameiC7Q8T3_CATAD
AccessioniPrimary (citable) accession number: C7Q8T3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: November 26, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3