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C7Q8T3

- C7Q8T3_CATAD

UniProt

C7Q8T3 - C7Q8T3_CATAD

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Protein

Probable DNA ligase

Gene
lig, Caci_1425
Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei224 – 2241ATP By similarityUniRule annotation
Active sitei226 – 2261N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei231 – 2311ATP By similarityUniRule annotation
Binding sitei246 – 2461ATP By similarityUniRule annotation
Binding sitei275 – 2751ATP By similarityUniRule annotation
Binding sitei315 – 3151ATP By similarityUniRule annotation
Binding sitei387 – 3871ATP By similarityUniRule annotation
Binding sitei393 – 3931ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCACI479433:GI6Z-1441-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Caci_1425Imported
OrganismiCatenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)Imported
Taxonomic identifieri479433 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCatenulisporineaeCatenulisporaceaeCatenulispora
ProteomesiUP000000851: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi479433.Caci_1425.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK01971.
OMAiVPIVIPY.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C7Q8T3-1 [UniParc]FASTAAdd to Basket

« Hide

MRLHDVATTS AAVAETSARS AKIALLAERL RTATPEEVAV AVHYLSGELP    50
QRQIGVGWAT LRELPAPADD SGGSNSSDGS DGSASTAGLE VAEVDRILEE 100
IGKTTGAGSQ ARRRDLLTAL FARATAEEQA FLRRLLTGEL RQGALDGVMA 150
DAVAKAADVP AAEVRRAAMF GGDLAAAAQT ALRAGVPGLR EVGLVVGRPI 200
QPMLAGTAED VPTALAKASP AALEWKLDGI RVQIHRDGDR VQVFTRSLDD 250
ITERLPEAVA LARSLQVTSA VLDGEALALA ADGRPRPFQE TASRTGSRRD 300
VERMREQIPL TVFLFDLLHL DGRDLVDLPS RERSDLLASI APPAAVAPRL 350
VTDDADAAEA FAKDALDRGH EGVVVKSLDA LYSAGRRGSG WLKVKPVHTL 400
DLVVLAAEWG HGRRRGWLSN LHLAARDPET GGFVMLGKTF KGMTDELLTW 450
QTERLRALQT SADDFAVHVR PELVVEVAFD GVQRSSRYPG GVTLRFARVV 500
RYREDKRAED ADTIDAVRAI GQGQEQA 527
Length:527
Mass (Da):56,425
Last modified:October 13, 2009 - v1
Checksum:iD45A9D33F9221C3B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001700 Genomic DNA. Translation: ACU70348.1.
RefSeqiYP_003112189.1. NC_013131.1.

Genome annotation databases

EnsemblBacteriaiACU70348; ACU70348; Caci_1425.
GeneIDi8332764.
KEGGicai:Caci_1425.
PATRICi21281360. VBICatAci36872_1442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001700 Genomic DNA. Translation: ACU70348.1 .
RefSeqi YP_003112189.1. NC_013131.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 479433.Caci_1425.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACU70348 ; ACU70348 ; Caci_1425 .
GeneIDi 8332764.
KEGGi cai:Caci_1425.
PATRICi 21281360. VBICatAci36872_1442.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K01971.
OMAi VPIVIPY.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci CACI479433:GI6Z-1441-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897.

Entry informationi

Entry nameiC7Q8T3_CATAD
AccessioniPrimary (citable) accession number: C7Q8T3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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