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C7PVV2

- PSB_CATAD

UniProt

C7PVV2 - PSB_CATAD

Protein

Proteasome subunit beta

Gene

prcB

Organism
Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

    Catalytic activityi

    Cleavage of peptide bonds with very broad specificity.UniRule annotation

    Enzyme regulationi

    The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei61 – 611NucleophileUniRule annotation

    GO - Molecular functioni

    1. threonine-type endopeptidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. modification-dependent protein catabolic process Source: UniProtKB-HAMAP
    2. proteasomal protein catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Protease, Threonine protease

    Enzyme and pathway databases

    BioCyciCACI479433:GI6Z-2452-MONOMER.
    UniPathwayiUPA00997.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteasome subunit betaUniRule annotation (EC:3.4.25.1UniRule annotation)
    Alternative name(s):
    20S proteasome beta subunitUniRule annotation
    Proteasome core protein PrcBUniRule annotation
    Gene namesi
    Name:prcBUniRule annotation
    Ordered Locus Names:Caci_2426
    OrganismiCatenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897)
    Taxonomic identifieri479433 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCatenulisporineaeCatenulisporaceaeCatenulispora
    ProteomesiUP000000851: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. proteasome core complex, beta-subunit complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm, Proteasome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 6060Removed in mature form; by autocatalysisUniRule annotationPRO_0000397502Add
    BLAST
    Chaini61 – 288228Proteasome subunit betaPRO_0000397503Add
    BLAST

    Keywords - PTMi

    Autocatalytic cleavage, Zymogen

    Interactioni

    Subunit structurei

    The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC.UniRule annotation

    Protein-protein interaction databases

    STRINGi479433.Caci_2426.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase T1B family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0638.
    HOGENOMiHOG000245308.
    KOiK03433.
    OMAiFQVELEH.
    OrthoDBiEOG6XM79W.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_02113_B. Proteasome_B_B.
    InterProiIPR029055. Ntn_hydrolases_N.
    IPR022483. Pept_T1A_Psome_suB_actinobac.
    IPR000243. Pept_T1A_subB.
    IPR001353. Proteasome_sua/b.
    IPR023333. Proteasome_suB-type.
    [Graphical view]
    PfamiPF00227. Proteasome. 1 hit.
    [Graphical view]
    PRINTSiPR00141. PROTEASOME.
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR03690. 20S_bact_beta. 1 hit.
    PROSITEiPS51476. PROTEASOME_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C7PVV2-1 [UniParc]FASTAAdd to Basket

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    MESNADWGSR GGLPQAFLTP GISSFSEFLK GFAPEYLPSG RPLPGGLGSA    50
    SAAGDIAPHG TTIVSIAFPG GVLLAGDRRA TMGNFIAQRD IEKVFPADEF 100
    SAVGIAGSAG LAVEVVRLFQ LELEHYEKIE GVTLSTDGKA NRLATMIRGN 150
    LAMAMQGLAV VPLFAGYDEE TGQGRIFSYD VTGGMYEEHD FYSVGSGSMF 200
    ARGALKKLFR PDFTAEDAAV AAVQALYDAA DDDSATGGPD LFRKIFPVVA 250
    VVTEDGYRRL PDEELSTLVE SIMDARRVVP DGPRSPLR 288
    Length:288
    Mass (Da):30,564
    Last modified:October 13, 2009 - v1
    Checksum:i6DAEA30552147A2D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001700 Genomic DNA. Translation: ACU71344.1.
    RefSeqiYP_003113185.1. NC_013131.1.

    Genome annotation databases

    EnsemblBacteriaiACU71344; ACU71344; Caci_2426.
    GeneIDi8333775.
    KEGGicai:Caci_2426.
    PATRICi21283444. VBICatAci36872_2475.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001700 Genomic DNA. Translation: ACU71344.1 .
    RefSeqi YP_003113185.1. NC_013131.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 479433.Caci_2426.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACU71344 ; ACU71344 ; Caci_2426 .
    GeneIDi 8333775.
    KEGGi cai:Caci_2426.
    PATRICi 21283444. VBICatAci36872_2475.

    Phylogenomic databases

    eggNOGi COG0638.
    HOGENOMi HOG000245308.
    KOi K03433.
    OMAi FQVELEH.
    OrthoDBi EOG6XM79W.

    Enzyme and pathway databases

    UniPathwayi UPA00997 .
    BioCyci CACI479433:GI6Z-2452-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_02113_B. Proteasome_B_B.
    InterProi IPR029055. Ntn_hydrolases_N.
    IPR022483. Pept_T1A_Psome_suB_actinobac.
    IPR000243. Pept_T1A_subB.
    IPR001353. Proteasome_sua/b.
    IPR023333. Proteasome_suB-type.
    [Graphical view ]
    Pfami PF00227. Proteasome. 1 hit.
    [Graphical view ]
    PRINTSi PR00141. PROTEASOME.
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR03690. 20S_bact_beta. 1 hit.
    PROSITEi PS51476. PROTEASOME_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 44928 / NRRL B-24433 / NBRC 102108 / JCM 14897.

    Entry informationi

    Entry nameiPSB_CATAD
    AccessioniPrimary (citable) accession number: C7PVV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 10, 2010
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3