C7PNY6 (C7PNY6_CHIPD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116
Short name=dUTPase HAMAP MF_00116
EC=3.6.1.23 HAMAP MF_00116

Alternative name(s):
dUTP pyrophosphatase HAMAP MF_00116

Gene names

Name:	dut HAMAP MF_00116
Ordered Locus Names:	Cpin_1185

Organism

Chitinophaga pinensis (strain ATCC 43595 / DSM 2588 / NCIB 11800 / UQM 2034) [Complete proteome] [HAMAP]

Taxonomic identifier

485918 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Sphingobacteriia › Sphingobacteriales › Chitinophagaceae › Chitinophaga

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116 SAAS SAAS008181
Catalytic activity	dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116 SAAS SAAS008181
Cofactor	Magnesium By similarity. HAMAP MF_00116 SAAS SAAS008181
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116
Sequence similarities	Belongs to the dUTPase family. HAMAP MF_00116

Ontologies

Keywords
Biological process	Nucleotide metabolism HAMAP MF_00116 SAAS SAAS008181
Ligand	Magnesium HAMAP MF_00116 SAAS SAAS008181 Metal-binding HAMAP MF_00116 SAAS SAAS008181
Molecular function	Hydrolase HAMAP MF_00116 SAAS SAAS008181 EMBL ACU58683.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	dUTP diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	66 – 68	3	Substrate binding By similarity HAMAP MF_00116
	Region	83 – 85	3	Substrate binding By similarity HAMAP MF_00116
Sites
	Binding site	79	1	Substrate By similarity HAMAP MF_00116
	Binding site	93	1	Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP MF_00116

Sequences

	Sequence		Length	Mass (Da)
	C7PNY6 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: 5F62DDF1DF29264D	FASTA	147	15,726
	10 20 30 40 50 60 MAAITVKIIN KSANPLPAYA TAEAAGMDLR ANLETAISLQ PLERMLIPTG LFMELPTGYE 70 80 90 100 110 120 AQIRPRSGLA IKQGLTLLNT PGTIDADYRG EIKVIMINLS NEPQTIAHGE RIAQMVIAPF 130 140 VQAQLEAVEL LTETERGAGG FGHTGKS

References

[1]

"The complete genome of Chitinophaga pinensis DSM 2588." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., Sims D., Meinche L., Brettin T., Detter J.C., Han C. , Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S., Klenk H.-P., Eisen J.A. Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43595 / DSM 2588 / NCIB 11800 / UQM 2034.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001699 Genomic DNA. Translation: ACU58683.1.
RefSeq	YP_003120884.1. NC_013132.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C7PNY6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8357301.
GenomeReviews	Gene locus Cpin_1185 in contig CP001699_GR.
KEGG	cpi:Cpin_1185.
PATRIC	21350995. VBIChiPin99107_1174.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	LDLRACI.
Family and domain databases
HAMAP	MF_00116. dUTPase_bact. [Tree]
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
KO	K01520.
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. Dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C7PNY6_CHIPD

Accession

Primary (citable) accession number: C7PNY6

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	December 14, 2011
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)