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Protein

Kynureninase

Gene

kynU

Organism
Chitinophaga pinensis (strain ATCC 43595 / DSM 2588 / NCIB 11800 / UQM 2034)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041Pyridoxal phosphate; via amide nitrogenUniRule annotation
Binding sitei105 – 1051Pyridoxal phosphateUniRule annotation
Binding sitei217 – 2171Pyridoxal phosphateUniRule annotation
Binding sitei220 – 2201Pyridoxal phosphateUniRule annotation
Binding sitei242 – 2421Pyridoxal phosphateUniRule annotation
Binding sitei273 – 2731Pyridoxal phosphateUniRule annotation
Binding sitei301 – 3011Pyridoxal phosphateUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciCPIN485918:GHYR-1166-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:Cpin_1147Imported
OrganismiChitinophaga pinensis (strain ATCC 43595 / DSM 2588 / NCIB 11800 / UQM 2034)Imported
Taxonomic identifieri485918 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesSphingobacteriiaSphingobacterialesChitinophagaceaeChitinophaga
ProteomesiUP000002215 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei243 – 2431N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi485918.Cpin_1147.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 1354Pyridoxal phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242438.
KOiK01556.
OMAiRFWQPLS.
OrthoDBiEOG6N67XP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

C7PNU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFELSRRFAE EQDQSDPLKT YREQFYFPQR NGKDAIYFCG NSLGLQPKNV
60 70 80 90 100
KPAIEQELND WKHHAVEGYW NAENPWLYYQ QYCSKPLTKI VGASQEELTV
110 120 130 140 150
MNTLTVNLHL LLMSFYQPTK QRFKVLMEAG AFPSDQYALE TQVRLHGYNP
160 170 180 190 200
AEAIIEVAPR PGERLIREED IFEIIERESS SLAIILLGGI NYYTGQLFNM
210 220 230 240 250
QSITEVAHRV GAIVGFDLAH VVGNVPLNLH DWEVDFAVWC SYKYLNGGPG
260 270 280 290 300
AVGGAFIHEK HALDTNRQRL GGWWGNEEST RFKMEKGFKP KNRAEGWQIS
310 320 330 340 350
TAQVFNMVAL KASLELFESA GMAALRDKSI KLTNYLEFLL KHIENIKFEI
360 370 380 390 400
ITPKNCKERG AQLSLLFHEK GREIQQKMTD AGIIVDWREP GVIRISPAPL
410 420
YNSYGDVFHF YEIIANIDSN A
Length:421
Mass (Da):48,196
Last modified:October 12, 2009 - v1
Checksum:i7D769B2A1FAF59E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001699 Genomic DNA. Translation: ACU58645.1.
RefSeqiWP_012788821.1. NC_013132.1.
YP_003120846.1. NC_013132.1.

Genome annotation databases

EnsemblBacteriaiACU58645; ACU58645; Cpin_1147.
GeneIDi8357263.
KEGGicpi:Cpin_1147.
PATRICi21350917. VBIChiPin99107_1135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001699 Genomic DNA. Translation: ACU58645.1.
RefSeqiWP_012788821.1. NC_013132.1.
YP_003120846.1. NC_013132.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi485918.Cpin_1147.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACU58645; ACU58645; Cpin_1147.
GeneIDi8357263.
KEGGicpi:Cpin_1147.
PATRICi21350917. VBIChiPin99107_1135.

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242438.
KOiK01556.
OMAiRFWQPLS.
OrthoDBiEOG6N67XP.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.
BioCyciCPIN485918:GHYR-1166-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V_dom.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43595 / DSM 2588 / NCIB 11800 / UQM 2034Imported.

Entry informationi

Entry nameiC7PNU8_CHIPD
AccessioniPrimary (citable) accession number: C7PNU8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 12, 2009
Last sequence update: October 12, 2009
Last modified: March 31, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.