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C7PNU8

- C7PNU8_CHIPD

UniProt

C7PNU8 - C7PNU8_CHIPD

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Protein
Kynureninase
Gene
kynU, Cpin_1147
Organism
Chitinophaga pinensis (strain ATCC 43595 / DSM 2588 / NCIB 11800 / UQM 2034)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041Pyridoxal phosphate; via amide nitrogen By similarityUniRule annotation
Binding sitei105 – 1051Pyridoxal phosphate By similarityUniRule annotation
Binding sitei217 – 2171Pyridoxal phosphate By similarityUniRule annotation
Binding sitei220 – 2201Pyridoxal phosphate By similarityUniRule annotation
Binding sitei242 – 2421Pyridoxal phosphate By similarityUniRule annotation
Binding sitei273 – 2731Pyridoxal phosphate By similarityUniRule annotation
Binding sitei301 – 3011Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciCPIN485918:GHYR-1166-MONOMER.
UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynUUniRule annotation
Ordered Locus Names:Cpin_1147Imported
OrganismiChitinophaga pinensis (strain ATCC 43595 / DSM 2588 / NCIB 11800 / UQM 2034)Imported
Taxonomic identifieri485918 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesSphingobacteriiaSphingobacterialesChitinophagaceaeChitinophaga
ProteomesiUP000002215: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei243 – 2431N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi485918.Cpin_1147.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 1354Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242438.
KOiK01556.
OMAiVWDLAHS.
OrthoDBiEOG6N67XP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

C7PNU8-1 [UniParc]FASTAAdd to Basket

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MFELSRRFAE EQDQSDPLKT YREQFYFPQR NGKDAIYFCG NSLGLQPKNV    50
KPAIEQELND WKHHAVEGYW NAENPWLYYQ QYCSKPLTKI VGASQEELTV 100
MNTLTVNLHL LLMSFYQPTK QRFKVLMEAG AFPSDQYALE TQVRLHGYNP 150
AEAIIEVAPR PGERLIREED IFEIIERESS SLAIILLGGI NYYTGQLFNM 200
QSITEVAHRV GAIVGFDLAH VVGNVPLNLH DWEVDFAVWC SYKYLNGGPG 250
AVGGAFIHEK HALDTNRQRL GGWWGNEEST RFKMEKGFKP KNRAEGWQIS 300
TAQVFNMVAL KASLELFESA GMAALRDKSI KLTNYLEFLL KHIENIKFEI 350
ITPKNCKERG AQLSLLFHEK GREIQQKMTD AGIIVDWREP GVIRISPAPL 400
YNSYGDVFHF YEIIANIDSN A 421
Length:421
Mass (Da):48,196
Last modified:October 13, 2009 - v1
Checksum:i7D769B2A1FAF59E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001699 Genomic DNA. Translation: ACU58645.1.
RefSeqiWP_012788821.1. NC_013132.1.
YP_003120846.1. NC_013132.1.

Genome annotation databases

EnsemblBacteriaiACU58645; ACU58645; Cpin_1147.
GeneIDi8357263.
KEGGicpi:Cpin_1147.
PATRICi21350917. VBIChiPin99107_1135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001699 Genomic DNA. Translation: ACU58645.1 .
RefSeqi WP_012788821.1. NC_013132.1.
YP_003120846.1. NC_013132.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 485918.Cpin_1147.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACU58645 ; ACU58645 ; Cpin_1147 .
GeneIDi 8357263.
KEGGi cpi:Cpin_1147.
PATRICi 21350917. VBIChiPin99107_1135.

Phylogenomic databases

eggNOGi COG3844.
HOGENOMi HOG000242438.
KOi K01556.
OMAi VWDLAHS.
OrthoDBi EOG6N67XP.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .
BioCyci CPIN485918:GHYR-1166-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43595 / DSM 2588 / NCIB 11800 / UQM 2034.

Entry informationi

Entry nameiC7PNU8_CHIPD
AccessioniPrimary (citable) accession number: C7PNU8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 3, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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