Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotation
Biological processPorphyrin biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciMFER573064:G1GFN-1421-MONOMER
UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:Mefer_1387Imported
OrganismiMethanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86) (Methanococcus fervens)Imported
Taxonomic identifieri573064 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000001495 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei266N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi573064.Mefer_1387

Structurei

3D structure databases

ProteinModelPortaliC7P9G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00918 Archaea
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG093Z024H

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.101 hit
3.90.1150.102 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

C7P9G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLKMDKSKE LFEEAKKYLV GGVNSPVRYF KPYPFFVKKA KDCYLYDVDG
60 70 80 90 100
NCYIDYCLAY GPMVLGHANE KIVEAVKKQL ELGSAYGCPT EKEIILAKEV
110 120 130 140 150
VKRVPCAEMV RFVNSGTEAT MSAIRLARGV TGRKKIIKFD GAYHGAHDYV
160 170 180 190 200
LVKSGSGALT HGHPNSPGIP EETTKNTILV PFNDEDAVKR AINENKDEIA
210 220 230 240 250
CVIVEPVMGN VGCILPKEGY LKFLREIAEE NDILLIFDEV ITGFRLAKGG
260 270 280 290 300
AQEYFDVVPD IATLGKILGG GFPIGAIVGK REIMENFSPL GAIYQAGTFN
310 320 330 340 350
GNPISITAGI ATLEQLDDKF YKETSRTAKI LADALRELAD KYNIKAKVYN
360 370 380 390 400
IASMFQIYFN DKDVVNYEIA KQSDVNKFMK YFWGLLERGV FVPPSQFECC
410 420
FTSIKHDDEV IDKTINAMED VFRSLE
Length:426
Mass (Da):47,464
Last modified:October 13, 2009 - v1
Checksum:i66874EBEC7A03268
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001696 Genomic DNA Translation: ACV25194.1
RefSeqiWP_015791927.1, NC_013156.1

Genome annotation databases

EnsemblBacteriaiACV25194; ACV25194; Mefer_1387
GeneIDi8366092
KEGGimfe:Mefer_1387

Similar proteinsi

Entry informationi

Entry nameiC7P9G2_METFA
AccessioniPrimary (citable) accession number: C7P9G2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported