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C7P995

- C7P995_METFA

UniProt

C7P995 - C7P995_METFA

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Protein
Ribulose bisphosphate carboxylase
Gene
rbcL, Mefer_1318
Organism
Methanocaldococcus fervens (strain DSM 4213 / JCM 157852 / AG86) (Methanococcus fervens)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei153 – 1531Proton acceptor By similarityUniRule annotation
Binding sitei155 – 1551Substrate By similarityUniRule annotation
Metal bindingi179 – 1791Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi181 – 1811Magnesium By similarityUniRule annotation
Metal bindingi182 – 1821Magnesium By similarityUniRule annotation
Active sitei269 – 2691Proton acceptor By similarityUniRule annotation
Binding sitei270 – 2701Substrate By similarityUniRule annotation
Binding sitei302 – 3021Substrate By similarityUniRule annotation
Sitei309 – 3091Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMFER573064:GHUI-1360-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:Mefer_1318Imported
OrganismiMethanocaldococcus fervens (strain DSM 4213 / JCM 157852 / AG86) (Methanococcus fervens)Imported
Taxonomic identifieri573064 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
ProteomesiUP000001495: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei179 – 1791N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi573064.Mefer_1318.

Structurei

3D structure databases

ProteinModelPortaliC7P995.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni353 – 3553Substrate binding By similarityUniRule annotation
Regioni375 – 3784Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1850.
HOGENOMiHOG000230831.
KOiK01601.
OMAiFTQDWAS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01133. RuBisCO_L_type3.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

C7P995-1 [UniParc]FASTAAdd to Basket

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MDYIDLNYTP NENDLLSCMI IKGENLEKLA NEIAGESSIG TWTKVQTMKS    50
DIYTKLKPKV YEIKEIGNEG RYKIGLIKIA YPLYAFEINN MPGVLAGIAG 100
NIFGMKIAKG LRILDFRFPE EFVKSYKGPR FGIEGVRKTL KIKERPLLGT 150
IVKPKVGLRT EEHAKVAYEA WVGGVDLVKD DENLTSQEFN KFEDRVYKTL 200
EMRDKAEEET GERKAYMPNI TAPYREMLRR AEIAEDAGSE YVMIDVVVSG 250
FSAVQSFREE EFNFIIHAHR AMHAAITRGR DFGISMLALA KIYRLLGVDQ 300
LHIGTVVGKM EGGEKEVKAI RDEIVYDKVE ADNENKFFNQ EWFGINPIFP 350
VSSGGVHPKL VPKIVEILGR DLIIQAGGGV HGHPDGTKAG AKAMRAAIEA 400
VVEGKSLEEK AEEVEELKKA LGYWK 425
Length:425
Mass (Da):47,698
Last modified:October 13, 2009 - v1
Checksum:i0CC57F4A783A5602
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001696 Genomic DNA. Translation: ACV25127.1.
RefSeqiYP_003128627.1. NC_013156.1.

Genome annotation databases

EnsemblBacteriaiACV25127; ACV25127; Mefer_1318.
GeneIDi8366021.
KEGGimfe:Mefer_1318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001696 Genomic DNA. Translation: ACV25127.1 .
RefSeqi YP_003128627.1. NC_013156.1.

3D structure databases

ProteinModelPortali C7P995.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 573064.Mefer_1318.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACV25127 ; ACV25127 ; Mefer_1318 .
GeneIDi 8366021.
KEGGi mfe:Mefer_1318.

Phylogenomic databases

eggNOGi COG1850.
HOGENOMi HOG000230831.
KOi K01601.
OMAi FTQDWAS.

Enzyme and pathway databases

BioCyci MFER573064:GHUI-1360-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01133. RuBisCO_L_type3.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Methanocaldococcus fervens AG86."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Lupa-Sieprawska M., Whitman W.B.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 4213 / JCM 157852 / AG86.

Entry informationi

Entry nameiC7P995_METFA
AccessioniPrimary (citable) accession number: C7P995
Entry historyi
Integrated into UniProtKB/TrEMBL: October 13, 2009
Last sequence update: October 13, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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