C7P8M1 (C7P8M1_METFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Imidazoleglycerol-phosphate dehydratase HAMAP-Rule MF_00076
Short name=IGPD HAMAP-Rule MF_00076
EC=4.2.1.19 HAMAP-Rule MF_00076

Gene names

Name:	hisB HAMAP-Rule MF_00076
Ordered Locus Names:	Mefer_1092 EMBL ACV24903.1

Organism

Methanocaldococcus fervens (strain DSM 4213 / JCM 157852 / AG86) (Methanococcus fervens) [Complete proteome] [HAMAP] EMBL ACV24903.1

Taxonomic identifier

573064 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanococci › Methanococcales › Methanocaldococcaceae › Methanocaldococcus › Methanocaldococcus fervens

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. HAMAP-Rule MF_00076
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9. HAMAP-Rule MF_00076
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00076.
Sequence similarities	Belongs to the imidazoleglycerol-phosphate dehydratase family. HAMAP-Rule MF_00076

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis HAMAP-Rule MF_00076
Cellular component	Cytoplasm HAMAP-Rule MF_00076
Molecular function	Lyase HAMAP-Rule MF_00076 EMBL ACV24903.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	imidazoleglycerol-phosphate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C7P8M1 [UniParc]. Last modified October 13, 2009. Version 1. Checksum: 2F868E62BA9A6683	FASTA	192	21,609
	10 20 30 40 50 60 MRVFEVMRET KETNIYLKIN IDGTGKYKID TGIPFFDHLL SSFAKHGCFD LIVKARGDLE 70 80 90 100 110 120 VDDHHTVEDV GICLGLALNQ IERKNIFRFG WAIIPMDDAR ATVAIDLGGR SYCVGNYKPN 130 140 150 160 170 180 REFVGDLATE NINHFFESVA SYGMLNIHYD VIGKNEHHKA EALFKAFGVA LDLATKIDER 190 KGIISTKGEI KL

References

[1]

"Complete sequence of chromosome of Methanocaldococcus fervens AG86." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Lupa-Sieprawska M., Whitman W.B. Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 4213 / JCM 157852 / AG86.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001696 Genomic DNA. Translation: ACV24903.1.
RefSeq	YP_003128403.1. NC_013156.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	573064.Mefer_1092.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACV24903; ACV24903; Mefer_1092.
GeneID	8365793.
KEGG	mfe:Mefer_1092.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0131.
HOGENOM	HOG000228064.
KO	K01693.
OMA	STENVVH.
ProtClustDB	PRK00951.
Enzyme and pathway databases
BioCyc	MFER573064:GHUI-1166-MONOMER.
UniPathway	UPA00031; UER00011.
Family and domain databases
HAMAP	MF_00076. HisB.
InterPro	IPR000807. ImidazoleglycerolP_deHydtase. IPR020565. ImidazoleglycerP_deHydtase_CS. IPR020568. Ribosomal_S5_D2-typ_fold. [Graphical view]
PANTHER	PTHR23133:SF2. PTHR23133:SF2. 1 hit.
Pfam	PF00475. IGPD. 1 hit. [Graphical view]
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 2 hits.
PROSITE	PS00954. IGP_DEHYDRATASE_1. 1 hit. PS00955. IGP_DEHYDRATASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C7P8M1_METFA

Accession

Primary (citable) accession number: C7P8M1

Entry history

Integrated into UniProtKB/TrEMBL:	October 13, 2009
Last sequence update:	October 13, 2009
Last modified:	May 1, 2013
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)